Detail Information

Basic Information:


  VIRBase ID:  

HHID00071993

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:           HLA-DPA1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3121-3p HLA-DPA1
miRBase
Accession/Entrez ID		 MIMAT0014983 3113
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DP(W3)//DP(W4)//DPA1//HLA-DP1A//HLA-DPA//HLA-DPB1//HLADP//HLASB//PLT1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-3121-3p
rs1006143795 chr1:180438334    T/C
rs778817728 chr1:180438323    T/C
rs887772082 chr1:180438327    C/T
rs911596096 chr1:180438331    G/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HLA-DPA1
chr6:33032815-33032816(-) m6A 3'UTR//exon       28052920
chr6:33032850-33032851(-) m6A 3'UTR//exon       28052920
chr6:33037470-33037471(-) m6A CDS//exon       -
chr6:33037549-33037550(-) m6A CDS//exon       -
chr6:33037560-33037561(-) m6A CDS//exon       -
chr6:33037619-33037620(-) m6A CDS//exon       -
chr6:33037659-33037660(-) m6A CDS//exon       -
chr6:33041333-33041334(-) m6A CDS//exon//intron       24981863//28052920
chr6:33041356-33041357(-) m6A 5'UTR//exon//intron       24981863//28052920

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3121-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
HLA-DPA1
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3121-3p
Interactor2: HLA-DPA1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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