Basic Information:

  VIRBase ID:  

HHID00071990

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          ECT2:  NM_001349101     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	ECT2
miRBase Accession/Entrez ID	MIMAT0014983	1894
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARHGEF31

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ECT2	chr3:172506595(+) A-I      intronic chr3:172506594(+) A-I      intronic chr3:172495610(+) A-I      intronic chr3:172495609(+) A-I      intronic chr3:172495461(+) A-I      intronic chr3:172494766(+) A-I      intronic chr3:172494765(+) A-I      intronic chr3:172494764(+) A-I      intronic chr3:172494758(+) A-I      intronic chr3:172494739(+) A-I      intronic chr3:172494690(+) A-I      intronic chr3:172485712(+) A-I      intronic chr3:172492067(+) A-I      intronic chr3:172507216(+) A-I      intronic chr3:172507214(+) A-I      intronic chr3:172506686(+) A-I      intronic chr3:172520126(+) A-I      intronic chr3:172512963(+) A-I      intronic chr3:172508798(+) A-I      intronic chr3:172508744(+) A-I      intronic chr3:172508725(+) A-I      intronic chr3:172492068(+) A-I      intronic chr3:172508720(+) A-I      intronic chr3:172508711(+) A-I      intronic chr3:172485648(+) A-I      intronic chr3:172485160(+) A-I      intronic chr3:172495568(+) A-I      intronic chr3:172496466(+) A-I      intronic chr3:172514881(+) A-I      intronic chr3:172508686(+) A-I      intronic chr3:172508673(+) A-I      intronic chr3:172507256(+) A-I      intronic chr3:172512622(+) A-I      intronic chr3:172485622(+) A-I      intronic chr3:172507259(+) A-I      intronic chr3:172507166(+) A-I      intronic chr3:172494689(+) A-I      intronic chr3:172512966(+) A-I      intronic chr3:172507133(+) A-I      intronic chr3:172485651(+) A-I      intronic chr3:172485687(+) A-I      intronic chr3:172507215(+) A-I      intronic chr3:172497514(+) A-I      intronic chr3:172497561(+) A-I      intronic chr3:172512566(+) A-I      intronic chr3:172507071(+) A-I      intronic chr3:172507079(+) A-I      intronic chr3:172485722(+) A-I      intronic chr3:172513023(+) A-I      intronic chr3:172506672(+) A-I      intronic chr3:172506683(+) A-I      intronic chr3:172485661(+) A-I      intronic chr3:172512605(+) A-I      intronic chr3:172513007(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ECT2	chr3:172470076(+) A-T exon 5'UTR    21725310 chr3:172470076(+) A-C exon 5'UTR    21725310 chr3:172484978(+) A-G intron -    22484847 chr3:172485621(+) A-G intron -    22484847 chr3:172485622(+) A-G intron -    22484847 chr3:172485624(+) A-G intron -    22484847 chr3:172485651(+) A-G intron -    22484847 chr3:172485661(+) A-G intron -    22484847 chr3:172485687(+) A-G intron -    22484847 chr3:172485722(+) A-G intron -    22484847 chr3:172485796(+) A-G intron -    22484847 chr3:172494689(+) A-G intron -    22484847 chr3:172495434(+) A-G intron -    22484847 chr3:172495536(+) A-G intron -    22484847 chr3:172506672(+) A-G intron -    22484847 chr3:172506683(+) A-G intron -    22484847 chr3:172507071(+) A-G intron -    22484847 chr3:172507080(+) A-G intron -    22484847 chr3:172507133(+) A-G intron -    22484847 chr3:172507166(+) A-G intron -    22484847 chr3:172507215(+) A-G intron -    22484847 chr3:172507259(+) A-G intron -    22484847 chr3:172511437(+) A-G intron -    22484847 chr3:172512566(+) A-G intron -    22484847 chr3:172512605(+) A-G intron -    22484847 chr3:172512622(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ECT2	chr3:172468478-172468479(+) m6A 5'UTR       24981863 chr3:172468623-172468624(+) m6A 5'UTR       24284625//24209618//24981863//27773535 chr3:172468788-172468789(+) m6A 5'UTR//intron       24209618//24981863//27773535 chr3:172482154-172482155(+) m6A CDS       26404942//27773535 chr3:172482178-172482179(+) m6A CDS       26404942//27773535 chr3:172486891-172486892(+) m6A CDS       26404942 chr3:172491721-172491722(+) m6A CDS       26404942 chr3:172491733-172491734(+) m6A CDS       26404942 chr3:172501606-172501607(+) m6A CDS       27773535 chr3:172501625-172501626(+) m6A CDS       27773535 chr3:172501648-172501649(+) m6A CDS       27773535 chr3:172501668-172501669(+) m6A CDS       27773535 chr3:172501674-172501675(+) m6A CDS       27773535 chr3:172533451-172533452(+) m6A CDS//exon       26404942//27773535 chr3:172533489-172533490(+) m6A CDS//exon       26404942//27773535 chr3:172534507-172534508(+) m6A CDS//exon       26404942//27773535 chr3:172536171-172536172(+) m6A exon//intron       27773535 chr3:172538063-172538064(+) m6A 3'UTR//exon       26404942 chr3:172538085-172538086(+) m6A 3'UTR//exon       24981863//26404942 chr3:172538150-172538151(+) m6A 3'UTR       24981863//26404942 chr3:172538640-172538641(+) Y 3'UTR       26075521 chr3:172538671-172538672(+) m6A 3'UTR       27773535//22608085 chr3:172538687-172538688(+) m6A 3'UTR       27773535//22608085 chr3:172538707-172538708(+) m6A 3'UTR       27773535//22608085 chr3:172538820-172538821(+) m6A 3'UTR       24981863//27773535//22608085 chr3:172538843-172538844(+) m6A 3'UTR       24981863//27773535//22608085 chr3:172539231-172539232(+) m6A 3'UTR       27773535 chr3:172539253-172539254(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	ECT2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: ECT2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.