Basic Information:

  VIRBase ID:  

HHID00071987

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          CISH:  NM_145071     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	CISH
miRBase Accession/Entrez ID	MIMAT0014983	1154
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BACTS2//CIS//CIS-1//G18//SOCS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CISH	chr3:50644229-50644230(-) m6A 3'UTR//exon       24284625 chr3:50644303-50644304(-) m6A 3'UTR//exon       24284625 chr3:50644394-50644395(-) m6A 3'UTR//exon       24284625 chr3:50644407-50644408(-) m6A 3'UTR//exon       24284625 chr3:50644462-50644463(-) m6A 3'UTR//exon       24284625 chr3:50644562-50644563(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828 chr3:50644617-50644618(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//22608085 chr3:50644667-50644668(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//22608085 chr3:50644718-50644719(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//22575960//22608085 chr3:50644751-50644752(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//22575960//22608085 chr3:50644780-50644781(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//22608085 chr3:50644789-50644790(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//22608085 chr3:50644971-50644972(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr3:50644988-50644989(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr3:50645098-50645099(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr3:50645187-50645188(-) m6A CDS//exon       24284625//24981863//27371828 chr3:50645392-50645393(-) m6A CDS//exon       24284625 chr3:50645827-50645828(-) m6A CDS//exon       27371828 chr3:50645859-50645860(-) m6A CDS//exon       27371828 chr3:50645884-50645885(-) m6A CDS//exon       27371828 chr3:50645960-50645961(-) m6A CDS//exon       27371828 chr3:50645995-50645996(-) m6A CDS//exon       27371828 chr3:50646023-50646024(-) m6A CDS//exon       27371828 chr3:50649007-50649008(-) m6A exon//intron       27371828 chr3:50649082-50649083(-) m6A 5'UTR//exon       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	CISH	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: CISH

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.