Detail Information

Basic Information:


  VIRBase ID:  

HHID00071986

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:           CDKN1A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3121-3p CDKN1A
miRBase
Accession/Entrez ID		 MIMAT0014983 1026
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CAP20//CDKN1//CIP1//MDA-6//P21//p21CIP1//SDI1//WAF1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-3121-3p
rs1006143795 chr1:180438334    T/C
rs778817728 chr1:180438323    T/C
rs887772082 chr1:180438327    C/T
rs911596096 chr1:180438331    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CDKN1A
chr6:36651039(+) A-I      intronic
chr6:36651029(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CDKN1A
chr6:36649966(+) A-G intron -    22484847
chr6:36652654(+) A-G intron -    22484847
chr6:36652771(+) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CDKN1A
chr6:36646593-36646594(+) m6A 5'UTR//exon//intron       24284625//24981863
chr6:36646603-36646604(+) m6A 5'UTR//exon//intron       24284625//24981863
chr6:36651886-36651887(+) m6A CDS//exon       24284625
chr6:36651909-36651910(+) m6A CDS//exon       24284625
chr6:36651954-36651955(+) m6A CDS//exon       24284625//26404942//22575960
chr6:36652026-36652027(+) m6A CDS//exon       24284625//26404942//22575960
chr6:36652046-36652047(+) m6A CDS//exon       24284625//26404942
chr6:36652190-36652191(+) m6A CDS//exon       24284625//25456834//24981863//26404942
chr6:36652203-36652204(+) m6A CDS//exon       24284625//25456834//24981863//26404942
chr6:36652212-36652213(+) m6A CDS//exon       24284625//25456834//24981863//26404942
chr6:36652276-36652277(+) m6A CDS//exon       24284625//25456834//26404942
chr6:36652284-36652285(+) m6A CDS//exon       24284625//25456834//26404942
chr6:36652310-36652311(+) m6A CDS       25456834//26404942
chr6:36654000-36654001(+) m6A 3'UTR       26404942
chr6:36654008-36654009(+) m6A 3'UTR       26404942
chr6:36654037-36654038(+) m6A 3'UTR       26404942
chr6:36654085-36654086(+) m6A 3'UTR       26404942
chr6:36654476-36654477(+) m6A 3'UTR       -
chr6:36654492-36654493(+) m6A 3'UTR       -
chr6:36654498-36654499(+) Am 3'UTR       -
chr6:36654662-36654663(+) m6A 3'UTR       26404942
chr6:36654744-36654745(+) m6A 3'UTR       26404942
chr6:36654756-36654757(+) m6A 3'UTR       26404942
chr6:36654788-36654789(+) m6A 3'UTR       26404942
chr6:36654909-36654910(+) m6A 3'UTR       24284625
chr6:36654942-36654943(+) m6A 3'UTR       24284625
chr6:36654993-36654994(+) m6A 3'UTR       24284625
chr6:36655000-36655001(+) m6A 3'UTR       24284625
chr6:36655017-36655018(+) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3121-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
CDKN1A
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3121-3p
Interactor2: CDKN1A

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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