Basic Information:

  VIRBase ID:  

HHID00071983

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          CASP3:  NM_004346     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	CASP3
miRBase Accession/Entrez ID	MIMAT0014983	836
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CPP32//CPP32B//SCA-1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CASP3	chr4:185563395(-) A-I      intronic chr4:185563394(-) A-I      intronic chr4:185563384(-) A-I      intronic chr4:185563373(-) A-I      intronic chr4:185563404(-) A-I      intronic chr4:185563238(-) A-I      intronic chr4:185563248(-) A-I      intronic chr4:185563256(-) A-I      intronic chr4:185563258(-) A-I      intronic chr4:185563263(-) A-I      intronic chr4:185563366(-) A-I      intronic chr4:185563267(-) A-I      intronic chr4:185563281(-) A-I      intronic chr4:185563282(-) A-I      intronic chr4:185563287(-) A-I      intronic chr4:185558634(-) A-I      intronic chr4:185558588(-) A-I      intronic chr4:185558356(-) A-I      intronic chr4:185564752(-) A-I      intronic chr4:185564777(-) A-I      intronic chr4:185564768(-) A-I      intronic chr4:185564626(-) A-I      intronic chr4:185563358(-) A-I      intronic chr4:185557396(-) A-I      intronic chr4:185563253(-) A-I      intronic chr4:185557349(-) A-I      intronic chr4:185558689(-) A-I      intronic chr4:185558232(-) A-I      intronic chr4:185558615(-) A-I      intronic chr4:185551739(-) A-I      intronic chr4:185558568(-) A-I      intronic chr4:185563319(-) A-I      intronic chr4:185566909(-) A-I      intronic chr4:185566948(-) A-I      intronic chr4:185558311(-) A-I      intronic chr4:185558258(-) A-I      intronic chr4:185558672(-) A-I      intronic chr4:185560238(-) A-I      intronic chr4:185560360(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CASP3	chr4:185570553(-) A-I exon 5'UTR    19478186 chr4:185558311(-) A-G intron -    22484847 chr4:185558672(-) A-G intron -    22484847 chr4:185563358(-) A-G intron -    22484847 chr4:185566794(-) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CASP3	chr4:185549472-185549473(-) m6A 3'UTR       24981863 chr4:185556524-185556525(-) m6A CDS       - chr4:185556542-185556543(-) m6A CDS       - chr4:185559556-185559557(-) m6A CDS       24981863 chr4:185559590-185559591(-) m6A CDS       24981863//27773535 chr4:185559599-185559600(-) m6A CDS       24981863//27773535 chr4:185565779-185565780(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	CASP3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: CASP3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.