Detail Information

Basic Information:


  VIRBase ID:  

HHID00071895

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-2278:           BNIP3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-2278 BNIP3
miRBase
Accession/Entrez ID		 MIMAT0011778 664
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - NIP3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-2278
rs377343613 chr9:94809995    C/T
rs938124353 chr9:94809994    C/T
rs991003784 chr9:94809996    T/C
rs1229108324 chr9:94809984    G/C
rs1229108324 chr9:94809984    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BNIP3
chr10:133789718(-) A-I      intronic
chr10:133786663(-) A-I      intronic
chr10:133790597(-) A-I      intronic
chr10:133790651(-) A-I      intronic
chr10:133788139(-) A-I      intronic
chr10:133788083(-) A-I      intronic
chr10:133788030(-) A-I      intronic
chr10:133790690(-) A-I      intronic
chr10:133788046(-) A-I      intronic
chr10:133790533(-) A-I      intronic
chr10:133787973(-) A-I      intronic
chr10:133790661(-) A-I      intronic
chr10:133788156(-) A-I      intronic
chr10:133787970(-) A-I      intronic
chr10:133790614(-) A-I      intronic
chr10:133788157(-) A-I      intronic
chr10:133790372(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BNIP3
chr10:133788046(-) A-I intron -    22327324
chr10:133787970(-) A-G intron -    22484847
chr10:133788046(-) A-G intron -    22484847
chr10:133788083(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BNIP3
chr10:133780036-133780037(-) m6A 3'UTR       -
chr10:133780047-133780048(-) m6A 3'UTR       -
chr10:133780062-133780063(-) m6A 3'UTR       -
chr10:133780073-133780074(-) m6A 3'UTR       -
chr10:133780090-133780091(-) m6A 3'UTR       -
chr10:133780173-133780174(-) m6A 3'UTR       -
chr10:133782327-133782328(-) m6A 3'UTR//intron       -
chr10:133782353-133782354(-) m6A 3'UTR//intron       -
chr10:133782406-133782407(-) m6A 3'UTR//intron       -
chr10:133782468-133782469(-) m6A 3'UTR//intron       -
chr10:133782474-133782475(-) m6A 3'UTR//intron       -
chr10:133782493-133782494(-) m6A 3'UTR//intron       -
chr10:133783080-133783081(-) m6A 3'UTR//intron       -
chr10:133783184-133783185(-) m6A 3'UTR//intron       -
chr10:133783197-133783198(-) m6A 3'UTR//intron       -
chr10:133783225-133783226(-) m6A 3'UTR//intron       -
chr10:133783737-133783738(-) m6A 3'UTR//intron       24284625
chr10:133783742-133783743(-) m6A 3'UTR//intron       24284625
chr10:133783983-133783984(-) m6A 3'UTR//intron       24284625//25456834
chr10:133784014-133784015(-) m6A 3'UTR//intron       24284625//25456834
chr10:133784240-133784241(-) m6A CDS       27773535
chr10:133784275-133784276(-) m6A CDS       27773535
chr10:133784418-133784419(-) m6A CDS       24981863//28052920//27773535
chr10:133786547-133786548(-) m6A CDS       24981863//27773535
chr10:133786575-133786576(-) m6A CDS       24981863//27773535
chr10:133786605-133786606(-) m6A CDS       24981863//27773535
chr10:133787368-133787369(-) m6A CDS//exon       24981863//27773535
chr10:133787433-133787434(-) m6A CDS//exon       27773535//27371828
chr10:133795340-133795341(-) m6A CDS//exon       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-2278
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
BNIP3
Chromatin K562 cells     -
Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-2278
Interactor2: BNIP3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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