Basic Information:

  VIRBase ID:  

HHID00071853

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7a-2-3p:  MIMAT0010195          C3orf38:  NM_173824     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7a-2-3p	C3orf38
miRBase Accession/Entrez ID	MIMAT0010195	285237
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7a-2-3p	rs781140476 chr11:122146535    G/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C3orf38	chr3:88198902-88198903(+) m6A 5'UTR       24981863 chr3:88198955-88198956(+) m6A 5'UTR       24981863 chr3:88198987-88198988(+) m6A 5'UTR       24981863 chr3:88199011-88199012(+) m6A 5'UTR       24981863 chr3:88199216-88199217(+) m6A CDS       24981863 chr3:88202422-88202423(+) m6A CDS//exon       22608085 chr3:88202509-88202510(+) m6A CDS       27773535//22608085 chr3:88202594-88202595(+) m6A CDS       24981863//27773535//22608085 chr3:88202601-88202602(+) m6A CDS       24981863//27773535//22608085 chr3:88205247-88205248(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr3:88205277-88205278(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:88205298-88205299(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:88205352-88205353(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:88205366-88205367(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:88205457-88205458(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:88205509-88205510(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:88205525-88205526(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:88205547-88205548(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:88205559-88205560(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:88205647-88205648(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:88205658-88205659(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:88205676-88205677(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:88205767-88205768(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:88205774-88205775(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:88205800-88205801(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:88205810-88205811(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:88205820-88205821(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:88205886-88205887(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:88205968-88205969(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:88205975-88205976(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:88206090-88206091(+) m6A 3'UTR//exon       24284625//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7a-2-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	C3orf38	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7a-2-3p
Interactor2: C3orf38

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.