Basic Information:

  VIRBase ID:  

HHID00071834

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7a-2-3p:  MIMAT0010195          TRIM71:  NM_001039111     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7a-2-3p	TRIM71
miRBase Accession/Entrez ID	MIMAT0010195	131405
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HYDCC1//LIN-41//LIN41

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7a-2-3p	rs781140476 chr11:122146535    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRIM71	chr3:32866115(+) A-I      intronic chr3:32866366(+) A-I      intronic chr3:32866367(+) A-I      intronic chr3:32866387(+) A-I      intronic chr3:32906778(+) A-I      intronic chr3:32918017(+) A-I      intronic chr3:32880317(+) A-I      intronic chr3:32873264(+) A-I      intronic chr3:32866426(+) A-I      intronic chr3:32870777(+) A-I      intronic chr3:32895389(+) A-I      intronic chr3:32867696(+) A-I      intronic chr3:32867735(+) A-I      intronic chr3:32870794(+) A-I      intronic chr3:32872403(+) A-I      intronic chr3:32895235(+) A-I      intronic chr3:32880362(+) A-I      intronic chr3:32879157(+) A-I      intronic chr3:32873815(+) A-I      intronic chr3:32869005(+) A-I      intronic chr3:32868324(+) A-I      intronic chr3:32925932(+) A-I      intronic chr3:32895297(+) A-I      intronic chr3:32871563(+) A-I      intronic chr3:32924209(+) A-I      intronic chr3:32895298(+) A-I      intronic chr3:32906766(+) A-I      intronic chr3:32915988(+) A-I      intronic chr3:32915972(+) A-I      intronic chr3:32879074(+) A-I      intronic chr3:32883343(+) A-I      intronic chr3:32866133(+) A-I      intronic chr3:32873168(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TRIM71	chr3:32879074(+) A-G intron -    22484847 chr3:32933339(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRIM71	chr3:32859590-32859591(+) m6A CDS       25456834 chr3:32931981-32931982(+) m6A CDS       25456834 chr3:32931999-32932000(+) m6A CDS       25456834//24981863 chr3:32932031-32932032(+) m6A CDS       25456834//24981863 chr3:32932334-32932335(+) m6A CDS       25456834//24981863//22608085 chr3:32932413-32932414(+) m6A CDS       25456834//24981863//22608085 chr3:32932539-32932540(+) m6A CDS       25456834//22608085 chr3:32932713-32932714(+) m6A CDS       25456834//24981863//22608085 chr3:32932778-32932779(+) m6A CDS       25456834//24981863//22608085 chr3:32932848-32932849(+) m6A CDS       25456834//24981863//22608085 chr3:32932857-32932858(+) m6A CDS       25456834//24981863//22608085 chr3:32932899-32932900(+) m6A CDS       25456834//24981863//22608085 chr3:32933103-32933104(+) m6A CDS       25456834//24981863//22608085 chr3:32933139-32933140(+) m6A CDS       25456834//24981863//22608085 chr3:32933220-32933221(+) m6A CDS       25456834//24981863//22608085 chr3:32933271-32933272(+) m6A CDS       25456834//24981863//22608085 chr3:32939122-32939123(+) m6A 3'UTR       27773535 chr3:32939225-32939226(+) m6A 3'UTR       27773535 chr3:32939246-32939247(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7a-2-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TRIM71	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7a-2-3p
Interactor2: TRIM71

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.