Basic Information:

  VIRBase ID:  

HHID00071619

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-2110:  MIMAT0010133          NAT10:  NM_024662     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-2110	NAT10
miRBase Accession/Entrez ID	MIMAT0010133	55226
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALP//Kre33//NET43

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-2110	rs114530801 chr10:114174163    G/A rs114530801 chr10:114174163    G/C rs114530801 chr10:114174163    G/T rs1168982220 chr10:114174162    C/G rs1188283086 chr10:114174156    A/T rs1246581316 chr10:114174158    C/T rs1412803607 chr10:114174164    T/A rs1431021422 chr10:114174157    G/C rs1476834649 chr10:114174154    TCAG/T rs192664871 chr10:114174154    T/C rs192664871 chr10:114174154    T/G rs573692968 chr10:114174159    G/A rs573692968 chr10:114174159    G/C rs755562830 chr10:114174148    CCTCA/C rs1178383827 chr10:114174165    T/G rs1418383763 chr10:114174167    C/T rs1434681640 chr10:114174169    C/T rs745914474 chr10:114174166    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NAT10	chr11:34149821(+) A-I      intronic chr11:34149842(+) A-I      intronic chr11:34149826(+) A-I      intronic chr11:34128610(+) A-I      intronic chr11:34149820(+) A-I      intronic chr11:34155590(+) A-I      intronic chr11:34128661(+) A-I      intronic chr11:34157729(+) A-I      intronic chr11:34149846(+) A-I      intronic chr11:34129213(+) A-I      intronic chr11:34147295(+) A-I      intronic chr11:34151418(+) A-I      intronic chr11:34149780(+) A-I      intronic chr11:34155600(+) A-I      intronic chr11:34151219(+) A-I      intronic chr11:34128784(+) A-I      intronic chr11:34147300(+) A-I      intronic chr11:34128698(+) A-I      intronic chr11:34129405(+) A-I      intronic chr11:34155596(+) A-I      intronic chr11:34129301(+) A-I      intronic chr11:34143169(+) A-I      intronic chr11:34128798(+) A-I      intronic chr11:34129250(+) A-I      intronic chr11:34128829(+) A-I      intronic chr11:34129350(+) A-I      intronic chr11:34157359(+) A-I      intronic chr11:34129219(+) A-I      intronic chr11:34129342(+) A-I      intronic chr11:34143616(+) A-I      intronic chr11:34147470(+) A-I      intronic chr11:34129264(+) A-I      intronic chr11:34143602(+) A-I      intronic chr11:34147255(+) A-I      intronic chr11:34143153(+) A-I      intronic chr11:34128680(+) A-I      intronic chr11:34129347(+) A-I      intronic chr11:34129403(+) A-I      intronic chr11:34157363(+) A-I      intronic chr11:34129311(+) A-I      intronic chr11:34129328(+) A-I      intronic chr11:34157771(+) A-I      intronic chr11:34153505(+) A-I      intronic chr11:34157812(+) A-I      intronic chr11:34138167(+) A-I      intronic chr11:34149722(+) A-I      intronic chr11:34128817(+) A-I      intronic chr11:34157648(+) A-I      intronic chr11:34128681(+) A-I      intronic chr11:34157358(+) A-I      intronic chr11:34140323(+) A-I      intronic chr11:34149648(+) A-I      intronic chr11:34157685(+) A-I      intronic chr11:34128671(+) A-I      intronic chr11:34129354(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NAT10	chr11:34128680(+) A-I intron -    22327324 chr11:34128680(+) A-G intron -    22484847 chr11:34128681(+) A-G intron -    22484847 chr11:34129219(+) A-G intron -    22484847 chr11:34129342(+) A-G intron -    22484847 chr11:34129347(+) A-G intron -    22484847 chr11:34129354(+) A-G intron -    22484847 chr11:34129403(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NAT10	chr11:34127226-34127227(+) m6A 5'UTR//exon       24284625//24981863//22575960 chr11:34135341-34135342(+) Y CDS       26075521 chr11:34139120-34139121(+) Cm intron       - chr11:34145928-34145929(+) m6A CDS//intron       - chr11:34145938-34145939(+) m6A CDS//intron       - chr11:34149050-34149051(+) m6A CDS//intron       - chr11:34152456-34152457(+) m6A CDS//intron       - chr11:34163346-34163347(+) m6A CDS//intron       24209618//24981863//27773535 chr11:34163850-34163851(+) m6A CDS//exon//intron       24209618//24981863//27773535 chr11:34163885-34163886(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535 chr11:34165035-34165036(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr11:34167657-34167658(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:34167663-34167664(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:34167669-34167670(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:34167689-34167690(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:34167697-34167698(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:34167704-34167705(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:34167720-34167721(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:34167748-34167749(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:34167795-34167796(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:34167810-34167811(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:34167936-34167937(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr11:34168168-34168169(+) m6A 3'UTR       24284625//24981863 chr11:34168190-34168191(+) m6A 3'UTR       24284625 chr11:34168285-34168286(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-2110	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	NAT10	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-2110
Interactor2: NAT10

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.