Basic Information:

  VIRBase ID:  

HHID00071609

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-2110:  MIMAT0010133          KLHL18:  NM_025010     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-2110	KLHL18
miRBase Accession/Entrez ID	MIMAT0010133	23276
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-2110	rs114530801 chr10:114174163    G/A rs114530801 chr10:114174163    G/C rs114530801 chr10:114174163    G/T rs1168982220 chr10:114174162    C/G rs1188283086 chr10:114174156    A/T rs1246581316 chr10:114174158    C/T rs1412803607 chr10:114174164    T/A rs1431021422 chr10:114174157    G/C rs1476834649 chr10:114174154    TCAG/T rs192664871 chr10:114174154    T/C rs192664871 chr10:114174154    T/G rs573692968 chr10:114174159    G/A rs573692968 chr10:114174159    G/C rs755562830 chr10:114174148    CCTCA/C rs1178383827 chr10:114174165    T/G rs1418383763 chr10:114174167    C/T rs1434681640 chr10:114174169    C/T rs745914474 chr10:114174166    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KLHL18	chr3:47334171(+) A-I      intronic chr3:47366813(+) A-I      intronic chr3:47366814(+) A-I      intronic chr3:47366872(+) A-I      intronic chr3:47367388(+) A-I      intronic chr3:47367410(+) A-I      intronic chr3:47369583(+) A-I      intronic chr3:47369600(+) A-I      intronic chr3:47370458(+) A-I      intronic chr3:47343799(+) A-I      intronic chr3:47359559(+) A-I      intronic chr3:47359594(+) A-I      intronic chr3:47332069(+) A-I      intronic chr3:47343895(+) A-I      intronic chr3:47355698(+) A-I      intronic chr3:47373639(+) A-I      intronic chr3:47343766(+) A-I      intronic chr3:47343386(+) A-I      intronic chr3:47343372(+) A-I      intronic chr3:47370470(+) A-I      intronic chr3:47370471(+) A-I      intronic chr3:47343360(+) A-I      intronic chr3:47343329(+) A-I      intronic chr3:47370508(+) A-I      intronic chr3:47370859(+) A-I      intronic chr3:47370969(+) A-I      intronic chr3:47371919(+) A-I      intronic chr3:47372265(+) A-I      intronic chr3:47372382(+) A-I      intronic chr3:47373615(+) A-I      intronic chr3:47355672(+) A-I      intronic chr3:47373662(+) A-I      intronic chr3:47373681(+) A-I      intronic chr3:47334346(+) A-I      intronic chr3:47334236(+) A-I      intronic chr3:47355662(+) A-I      intronic chr3:47334120(+) A-I      intronic chr3:47332051(+) A-I      intronic chr3:47329671(+) A-I      intronic chr3:47329076(+) A-I      intronic chr3:47329069(+) A-I      intronic chr3:47327482(+) A-I      intronic chr3:47327462(+) A-I      intronic chr3:47327450(+) A-I      intronic chr3:47327445(+) A-I      intronic chr3:47326563(+) A-I      intronic chr3:47326448(+) A-I      intronic chr3:47326435(+) A-I      intronic chr3:47325572(+) A-I      intronic chr3:47325570(+) A-I      intronic chr3:47325465(+) A-I      intronic chr3:47332077(+) A-I      intronic chr3:47332078(+) A-I      intronic chr3:47353075(+) A-I      intronic chr3:47332173(+) A-I      intronic chr3:47334237(+) A-I      intronic chr3:47334249(+) A-I      intronic chr3:47334285(+) A-I      intronic chr3:47326943(+) A-I      intronic chr3:47326952(+) A-I      intronic chr3:47326957(+) A-I      intronic chr3:47326968(+) A-I      intronic chr3:47329019(+) A-I      intronic chr3:47329237(+) A-I      intronic chr3:47329535(+) A-I      intronic chr3:47329551(+) A-I      intronic chr3:47329552(+) A-I      intronic chr3:47332008(+) A-I      intronic chr3:47332064(+) A-I      intronic chr3:47343828(+) A-I      intronic chr3:47373663(+) A-I      intronic chr3:47356025(+) A-I      intronic chr3:47373680(+) A-I      intronic chr3:47355742(+) A-I      intronic chr3:47356044(+) A-I      intronic chr3:47358866(+) A-I      intronic chr3:47359485(+) A-I      intronic chr3:47353051(+) A-I      intronic chr3:47353020(+) A-I      intronic chr3:47353016(+) A-I      intronic chr3:47352995(+) A-I      intronic chr3:47352979(+) A-I      intronic chr3:47352971(+) A-I      intronic chr3:47352710(+) A-I      intronic chr3:47352701(+) A-I      intronic chr3:47349945(+) A-I      intronic chr3:47349942(+) A-I      intronic chr3:47343896(+) A-I      intronic chr3:47359539(+) A-I      intronic chr3:47343854(+) A-I      intronic chr3:47337158(+) A-I      intronic chr3:47343864(+) A-I      intronic chr3:47337187(+) A-I      intronic chr3:47370480(+) A-I      intronic chr3:47355639(+) A-I      intronic chr3:47372339(+) A-I      intronic chr3:47372260(+) A-I      intronic chr3:47373661(+) A-I      intronic chr3:47372457(+) A-I      intronic chr3:47368290(+) A-I      intronic chr3:47373625(+) A-I      intronic chr3:47332052(+) A-I      intronic chr3:47329105(+) A-I      intronic chr3:47326974(+) A-I      intronic chr3:47373773(+) A-I      intronic chr3:47343810(+) A-I      intronic chr3:47366229(+) A-I      intronic chr3:47329474(+) A-I      intronic chr3:47329034(+) A-I      intronic chr3:47357930(+) A-I      intronic chr3:47371902(+) A-I      intronic chr3:47327352(+) A-I      intronic chr3:47334238(+) A-I      intronic chr3:47329149(+) A-I      intronic chr3:47341088(+) A-I      intronic chr3:47371973(+) A-I      intronic chr3:47371848(+) A-I      intronic chr3:47366230(+) A-I      intronic chr3:47325992(+) A-I      intronic chr3:47357872(+) A-I      intronic chr3:47372396(+) A-I      intronic chr3:47327282(+) A-I      intronic chr3:47326949(+) A-I      intronic chr3:47362206(+) A-I      intronic chr3:47368223(+) A-I      intronic chr3:47373755(+) A-I      intronic chr3:47345872(+) A-I      intronic chr3:47381346(+) A-I      intronic chr3:47329623(+) A-I      intronic chr3:47331198(+) A-I      intronic chr3:47325967(+) A-I      intronic chr3:47327389(+) A-I      intronic chr3:47329158(+) A-I      intronic chr3:47325943(+) A-I      intronic chr3:47372419(+) A-I      intronic chr3:47332172(+) A-I      intronic chr3:47373585(+) A-I      intronic chr3:47332091(+) A-I      intronic chr3:47341161(+) A-I      intronic chr3:47329039(+) A-I      intronic chr3:47326973(+) A-I      intronic chr3:47358441(+) A-I      intronic chr3:47326065(+) A-I      intronic chr3:47331232(+) A-I      intronic chr3:47345303(+) A-I      intronic chr3:47343385(+) A-I      intronic chr3:47325710(+) A-I      intronic chr3:47366326(+) A-I      intronic chr3:47325588(+) A-I      intronic chr3:47370602(+) A-I      intronic chr3:47372484(+) A-I      intronic chr3:47332021(+) A-I      intronic chr3:47369599(+) A-I      intronic chr3:47373568(+) A-I      intronic chr3:47373766(+) A-I      intronic chr3:47372456(+) A-I      intronic chr3:47372361(+) A-I      intronic chr3:47343415(+) A-I      intronic chr3:47331153(+) A-I      intronic chr3:47334275(+) A-I      intronic chr3:47372496(+) A-I      intronic chr3:47358742(+) A-I      intronic chr3:47329617(+) A-I      intronic chr3:47325615(+) A-I      intronic chr3:47343721(+) A-I      intronic chr3:47372387(+) A-I      intronic chr3:47371835(+) A-I      intronic chr3:47337197(+) A-I      intronic chr3:47353061(+) A-I      intronic chr3:47368300(+) A-I      intronic chr3:47359484(+) A-I      intronic chr3:47355627(+) A-I      intronic chr3:47370521(+) A-I      intronic chr3:47372301(+) A-I      intronic chr3:47332187(+) A-I      intronic chr3:47334138(+) A-I      intronic chr3:47327023(+) A-I      intronic chr3:47343427(+) A-I      intronic chr3:47368159(+) A-I      intronic chr3:47373748(+) A-I      intronic chr3:47343925(+) A-I      intronic chr3:47352706(+) A-I      intronic chr3:47368227(+) A-I      intronic chr3:47343379(+) A-I      intronic chr3:47326095(+) A-I      intronic chr3:47345134(+) A-I      intronic chr3:47371833(+) A-I      intronic chr3:47367712(+) A-I      intronic chr3:47337317(+) A-I      intronic chr3:47343403(+) A-I      intronic chr3:47372307(+) A-I      intronic chr3:47327378(+) A-I      intronic chr3:47371929(+) A-I      intronic chr3:47367397(+) A-I      intronic chr3:47325647(+) A-I      intronic chr3:47364708(+) A-I      intronic chr3:47366327(+) A-I      intronic chr3:47325926(+) A-I      intronic chr3:47372338(+) A-I      intronic chr3:47340793(+) A-I      intronic chr3:47329093(+) A-I      intronic chr3:47353103(+) A-I      intronic chr3:47341318(+) A-I      intronic chr3:47370601(+) A-I      intronic chr3:47341089(+) A-I      intronic chr3:47352684(+) A-I      intronic chr3:47332093(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KLHL18	chr3:47341213(+) A-I intron -    21960545 chr3:47372178(+) A-G intron -    22484847 chr3:47325467(+) A-G intron -    22484847 chr3:47325567(+) A-G intron -    22484847 chr3:47325568(+) A-G intron -    22484847 chr3:47325588(+) A-G intron -    22484847 chr3:47325601(+) A-G intron -    22484847 chr3:47325615(+) A-G intron -    22484847 chr3:47325679(+) A-G intron -    22484847 chr3:47325943(+) A-G intron -    22484847 chr3:47325967(+) A-G intron -    22484847 chr3:47326065(+) A-G intron -    22484847 chr3:47326095(+) A-G intron -    22484847 chr3:47326450(+) A-G intron -    22484847 chr3:47326949(+) A-G intron -    22484847 chr3:47327048(+) G-A intron -    22484847 chr3:47327389(+) A-G intron -    22484847 chr3:47329034(+) A-G intron -    22484847 chr3:47329039(+) A-G intron -    22484847 chr3:47329040(+) A-G intron -    22484847 chr3:47329093(+) A-G intron -    22484847 chr3:47329149(+) A-G intron -    22484847 chr3:47329158(+) A-G intron -    22484847 chr3:47329164(+) A-G intron -    22484847 chr3:47329540(+) A-G intron -    22484847 chr3:47331171(+) A-G intron -    22484847 chr3:47331977(+) A-G intron -    22484847 chr3:47332006(+) A-G intron -    22484847 chr3:47332021(+) A-G intron -    22484847 chr3:47332052(+) A-G intron -    22484847 chr3:47332091(+) A-G intron -    22484847 chr3:47334138(+) A-G intron -    22484847 chr3:47343355(+) A-G intron -    22484847 chr3:47343379(+) A-G intron -    22484847 chr3:47343385(+) A-G intron -    22484847 chr3:47343403(+) A-G intron -    22484847 chr3:47343415(+) A-G intron -    22484847 chr3:47343708(+) A-G intron -    22484847 chr3:47343810(+) A-G intron -    22484847 chr3:47343864(+) A-G intron -    22484847 chr3:47343868(+) A-G intron -    22484847 chr3:47343894(+) A-G intron -    22484847 chr3:47343925(+) A-G intron -    22484847 chr3:47345134(+) A-G intron -    22484847 chr3:47345303(+) A-G intron -    22484847 chr3:47345386(+) A-T intron -    22484847 chr3:47346312(+) A-G intron -    22484847 chr3:47352629(+) A-G intron -    22484847 chr3:47352684(+) A-G intron -    22484847 chr3:47352706(+) A-G intron -    22484847 chr3:47362130(+) A-G intron -    22484847 chr3:47362885(+) A-G intron -    22484847 chr3:47363074(+) A-G intron -    22484847 chr3:47370421(+) A-G intron -    22484847 chr3:47370480(+) A-G intron -    22484847 chr3:47370521(+) A-G intron -    22484847 chr3:47370601(+) A-G intron -    22484847 chr3:47370602(+) A-G intron -    22484847 chr3:47371835(+) A-G intron -    22484847 chr3:47371848(+) A-G intron -    22484847 chr3:47371867(+) A-G intron -    22484847 chr3:47371973(+) A-G intron -    22484847 chr3:47371987(+) A-G intron -    22484847 chr3:47372260(+) A-G intron -    22484847 chr3:47372301(+) A-G intron -    22484847 chr3:47372307(+) A-G intron -    22484847 chr3:47372394(+) A-G intron -    22484847 chr3:47372396(+) A-G intron -    22484847 chr3:47372402(+) A-G intron -    22484847 chr3:47372419(+) A-G intron -    22484847 chr3:47372422(+) A-G intron -    22484847 chr3:47372456(+) A-G intron -    22484847 chr3:47372457(+) A-G intron -    22484847 chr3:47372496(+) A-G intron -    22484847 chr3:47373661(+) A-G intron -    22484847 chr3:47373675(+) A-G intron -    22484847 chr3:47373678(+) A-G intron -    22484847 chr3:47373728(+) A-G intron -    22484847 chr3:47373777(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KLHL18	chr3:47371623-47371624(+) Cm 3'UTR//CDS//exon       - chr3:47376242-47376243(+) m6A 3'UTR//CDS//exon       24284625 chr3:47376274-47376275(+) m6A 3'UTR//CDS//exon       24284625 chr3:47378203-47378204(+) m6A 3'UTR//CDS//exon       24284625 chr3:47378215-47378216(+) m6A 3'UTR//CDS//exon       24284625 chr3:47378274-47378275(+) m6A exon//intron       24284625 chr3:47378449-47378450(+) m6A exon//intron       24209618 chr3:47378459-47378460(+) m6A exon//intron       24209618 chr3:47378470-47378471(+) m6A exon//intron       24209618 chr3:47378511-47378512(+) m6A exon//intron       24209618 chr3:47378552-47378553(+) m6A exon//intron       24209618 chr3:47378557-47378558(+) m6A exon//intron       24209618 chr3:47378563-47378564(+) m6A exon//intron       24209618 chr3:47380302-47380303(+) m6A exon//intron       24284625 chr3:47382071-47382072(+) m6A 3'UTR//CDS       24284625 chr3:47382143-47382144(+) m6A 3'UTR//CDS       24284625 chr3:47382162-47382163(+) m6A 3'UTR//CDS       24284625 chr3:47384212-47384213(+) m6A 3'UTR//CDS       24284625 chr3:47385049-47385050(+) m6A 3'UTR//CDS       24284625 chr3:47385210-47385211(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47385307-47385308(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47385315-47385316(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47385347-47385348(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47385359-47385360(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47385471-47385472(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47385493-47385494(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47385517-47385518(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47385639-47385640(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr3:47385677-47385678(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr3:47385698-47385699(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr3:47385857-47385858(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47385883-47385884(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47386074-47386075(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr3:47386104-47386105(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr3:47386120-47386121(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr3:47386128-47386129(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:47386141-47386142(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:47386171-47386172(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:47386203-47386204(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:47386409-47386410(+) m6A 3'UTR       24284625//24981863//22608085 chr3:47386594-47386595(+) m6A 3'UTR       24284625//24981863//22608085 chr3:47386697-47386698(+) m6A 3'UTR       24284625//24209618//22608085 chr3:47386827-47386828(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr3:47386844-47386845(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr3:47386885-47386886(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47386921-47386922(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr3:47387008-47387009(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:47387028-47387029(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:47387042-47387043(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:47387130-47387131(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr3:47387162-47387163(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr3:47388014-47388015(+) m6A 3'UTR       24284625//24981863//22608085 chr3:47388062-47388063(+) m6A 3'UTR       24284625//24981863//22608085 chr3:47388163-47388164(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-2110	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	KLHL18	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-2110
Interactor2: KLHL18

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.