Basic Information:

  VIRBase ID:  

HHID00071607

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-2110:  MIMAT0010133          COPG1:  NM_016128     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-2110	COPG1
miRBase Accession/Entrez ID	MIMAT0010133	22820
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	COPG

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-2110	rs114530801 chr10:114174163    G/A rs114530801 chr10:114174163    G/C rs114530801 chr10:114174163    G/T rs1168982220 chr10:114174162    C/G rs1188283086 chr10:114174156    A/T rs1246581316 chr10:114174158    C/T rs1412803607 chr10:114174164    T/A rs1431021422 chr10:114174157    G/C rs1476834649 chr10:114174154    TCAG/T rs192664871 chr10:114174154    T/C rs192664871 chr10:114174154    T/G rs573692968 chr10:114174159    G/A rs573692968 chr10:114174159    G/C rs755562830 chr10:114174148    CCTCA/C rs1178383827 chr10:114174165    T/G rs1418383763 chr10:114174167    C/T rs1434681640 chr10:114174169    C/T rs745914474 chr10:114174166    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	COPG1	chr3:128981701(+) A-I      intronic chr3:128990495(+) A-I      intronic chr3:128981742(+) A-I      intronic chr3:128984842(+) A-I      intronic chr3:128981251(+) A-I      intronic chr3:128978184(+) A-I      intronic chr3:128978143(+) A-I      intronic chr3:128978142(+) A-I      intronic chr3:128981706(+) A-I      intronic chr3:128981703(+) A-I      intronic chr3:128981278(+) A-I      intronic chr3:128981686(+) A-I      intronic chr3:128981241(+) A-I      intronic chr3:128981307(+) A-I      intronic chr3:128981358(+) A-I      intronic chr3:128981515(+) A-I      intronic chr3:128981637(+) A-I      intronic chr3:128981647(+) A-I      intronic chr3:128981170(+) A-I      intronic chr3:128981213(+) A-I      intronic chr3:128981237(+) A-I      intronic chr3:128981675(+) A-I      intronic chr3:128984889(+) A-I      intronic chr3:128977440(+) A-I      intronic chr3:128977466(+) A-I      intronic chr3:128978219(+) A-I      intronic chr3:128978224(+) A-I      intronic chr3:128981024(+) A-I      intronic chr3:128981370(+) A-I      intronic chr3:128978077(+) A-I      intronic chr3:128981439(+) A-I      intronic chr3:128981748(+) A-I      intronic chr3:128977375(+) A-I      intronic chr3:128978151(+) A-I      intronic chr3:128981303(+) A-I      intronic chr3:128981810(+) A-I      intronic chr3:128978153(+) A-I      intronic chr3:128981281(+) A-I      intronic chr3:128981607(+) A-I      intronic chr3:128981235(+) A-I      intronic chr3:128978051(+) A-I      intronic chr3:128981811(+) A-I      intronic chr3:128978148(+) A-I      intronic chr3:128981816(+) A-I      intronic chr3:128978050(+) A-I      intronic chr3:128981752(+) A-I      intronic chr3:128981023(+) A-I      intronic chr3:128981807(+) A-I      intronic chr3:128978157(+) A-I      intronic chr3:128981445(+) A-I      intronic chr3:128986405(+) A-I      intronic chr3:128981225(+) A-I      intronic chr3:128981697(+) A-I      intronic chr3:128978032(+) A-I      intronic chr3:128981462(+) A-I      intronic chr3:128981704(+) A-I      intronic chr3:128978249(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	COPG1	chr3:128981810(+) A-I intron -    22327324 chr3:128986488(+) A-I intron -    21960545 chr3:128988328(+) A-I intron -    21960545 chr3:128977320(+) A-G intron -    22484847 chr3:128978051(+) A-G intron -    22484847 chr3:128978077(+) A-G intron -    22484847 chr3:128978151(+) A-G intron -    22484847 chr3:128978157(+) A-G intron -    22484847 chr3:128981001(+) A-G intron -    22484847 chr3:128981165(+) A-G intron -    22484847 chr3:128981225(+) A-G intron -    22484847 chr3:128981235(+) A-G intron -    22484847 chr3:128981281(+) A-G intron -    22484847 chr3:128981303(+) A-G intron -    22484847 chr3:128981748(+) A-G intron -    22484847 chr3:128981810(+) A-G intron -    22484847 chr3:128981811(+) A-G intron -    22484847 chr3:128991962(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	COPG1	chr3:128968477-128968478(+) m6A 5'UTR//exon       24981863 chr3:128973574-128973575(+) Cm 3'UTR//CDS//exon       - chr3:128990721-128990722(+) m6A CDS//exon//intron       22575960 chr3:128991099-128991100(+) m6A CDS//exon//intron       22575960 chr3:128991116-128991117(+) m6A CDS//exon//intron       22575960 chr3:128991212-128991213(+) m6A CDS//exon       22575960 chr3:128991246-128991247(+) m6A CDS//exon       22575960 chr3:128991691-128991692(+) m6A CDS//exon       27773535 chr3:128991714-128991715(+) m6A CDS//exon       24981863//27773535 chr3:128992928-128992929(+) m6A 3'UTR//intron       24981863 chr3:128996335-128996336(+) m6A 3'UTR//exon       24284625//27773535 chr3:128996345-128996346(+) m6A 3'UTR//exon       24284625//27773535 chr3:128996373-128996374(+) m6A 3'UTR//exon       24284625//24981863//27773535 chr3:128996428-128996429(+) m6A 3'UTR//exon       24284625//24981863//27773535 chr3:128996521-128996522(+) m6A 3'UTR//exon       24284625//24981863//27773535 chr3:128996539-128996540(+) m6A 3'UTR//exon       24284625//24981863//27773535 chr3:128996575-128996576(+) m6A 3'UTR//exon       24284625//24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-2110	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	COPG1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-2110
Interactor2: COPG1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.