Basic Information:

  VIRBase ID:  

HHID00071602

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-2110:  MIMAT0010133          CD83:  NM_001040280     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-2110	CD83
miRBase Accession/Entrez ID	MIMAT0010133	9308
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BL11//HB15

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-2110	rs114530801 chr10:114174163    G/A rs114530801 chr10:114174163    G/C rs114530801 chr10:114174163    G/T rs1168982220 chr10:114174162    C/G rs1188283086 chr10:114174156    A/T rs1246581316 chr10:114174158    C/T rs1412803607 chr10:114174164    T/A rs1431021422 chr10:114174157    G/C rs1476834649 chr10:114174154    TCAG/T rs192664871 chr10:114174154    T/C rs192664871 chr10:114174154    T/G rs573692968 chr10:114174159    G/A rs573692968 chr10:114174159    G/C rs755562830 chr10:114174148    CCTCA/C rs1178383827 chr10:114174165    T/G rs1418383763 chr10:114174167    C/T rs1434681640 chr10:114174169    C/T rs745914474 chr10:114174166    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CD83	chr6:14121505(+) A-I      intronic chr6:14121558(+) A-I      intronic chr6:14121550(+) A-I      intronic chr6:14121535(+) A-I      intronic chr6:14121504(+) A-I      intronic chr6:14121606(+) A-I      intronic chr6:14121637(+) A-I      intronic chr6:14130920(+) A-I      intronic chr6:14121801(+) A-I      intronic chr6:14121643(+) A-I      intronic chr6:14121669(+) A-I      intronic chr6:14130840(+) A-I      intronic chr6:14121466(+) A-I      intronic chr6:14121420(+) A-I      intronic chr6:14121540(+) A-I      intronic chr6:14121785(+) A-I      intronic chr6:14127238(+) A-I      intronic chr6:14121543(+) A-I      intronic chr6:14121756(+) A-I      intronic chr6:14121445(+) A-I      intronic chr6:14121422(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CD83	chr6:14121591(+) A-I intron -    15258596   //21960545   //22327324 chr6:14121630(+) A-I intron -    15258596 chr6:14121642(+) A-I intron -    15258596 chr6:14121670(+) A-I intron -    15258596   //22327324 chr6:14121445(+) A-G intron -    22484847 chr6:14121543(+) A-G intron -    22484847 chr6:14121591(+) A-G intron -    22484847 chr6:14121637(+) A-G intron -    22484847 chr6:14121669(+) A-G intron -    22484847 chr6:14121670(+) A-G intron -    22484847 chr6:14123330(+) T-G intron -    22484847 chr6:14123331(+) G-T intron -    22484847 chr6:14127238(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CD83	chr6:14118237-14118238(+) m6A 5'UTR//CDS       24284625 chr6:14131780-14131781(+) m6A CDS       24284625 chr6:14131793-14131794(+) m6A CDS       24284625 chr6:14131806-14131807(+) m6A CDS       24284625 chr6:14131883-14131884(+) m6A CDS       24284625 chr6:14131906-14131907(+) m6A CDS       24284625 chr6:14131928-14131929(+) m6A CDS       24284625 chr6:14131946-14131947(+) m6A CDS       24284625 chr6:14133905-14133906(+) m6A CDS       24284625 chr6:14135452-14135453(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:14135457-14135458(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:14135595-14135596(+) m6A 3'UTR       24284625//24209618//22608085 chr6:14135643-14135644(+) m6A 3'UTR       24284625//24209618//26404942//22608085 chr6:14135734-14135735(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:14135823-14135824(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:14135833-14135834(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:14135860-14135861(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:14135942-14135943(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:14136035-14136036(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr6:14136070-14136071(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr6:14136193-14136194(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr6:14136210-14136211(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr6:14136379-14136380(+) m6A 3'UTR       24284625 chr6:14136550-14136551(+) m6A 3'UTR       24284625 chr6:14136607-14136608(+) Am 3'UTR       - chr6:14136671-14136672(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22608085 chr6:14136697-14136698(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22608085 chr6:14136751-14136752(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-2110	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	CD83	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-2110
Interactor2: CD83

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.