Basic Information:

  VIRBase ID:  

HHID00071597

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-2110:  MIMAT0010133          SHOC2:  NR_136749     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-2110	SHOC2
miRBase Accession/Entrez ID	MIMAT0010133	8036
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NSLH1//SIAA0862//SOC2//SUR8

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-2110	rs114530801 chr10:114174163    G/A rs114530801 chr10:114174163    G/C rs114530801 chr10:114174163    G/T rs1168982220 chr10:114174162    C/G rs1188283086 chr10:114174156    A/T rs1246581316 chr10:114174158    C/T rs1412803607 chr10:114174164    T/A rs1431021422 chr10:114174157    G/C rs1476834649 chr10:114174154    TCAG/T rs192664871 chr10:114174154    T/C rs192664871 chr10:114174154    T/G rs573692968 chr10:114174159    G/A rs573692968 chr10:114174159    G/C rs755562830 chr10:114174148    CCTCA/C rs1178383827 chr10:114174165    T/G rs1418383763 chr10:114174167    C/T rs1434681640 chr10:114174169    C/T rs745914474 chr10:114174166    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SHOC2	chr10:112685364(+) A-I      intronic chr10:112685398(+) A-I      intronic chr10:112757954(+) A-I      intronic chr10:112735810(+) A-I      intronic chr10:112685436(+) A-I      intronic chr10:112685491(+) A-I      intronic chr10:112756135(+) A-I      intronic chr10:112736322(+) A-I      intronic chr10:112746361(+) A-I      intronic chr10:112757796(+) A-I      intronic chr10:112684587(+) A-I      intronic chr10:112684678(+) A-I      intronic chr10:112685261(+) A-I      intronic chr10:112685328(+) A-I      intronic chr10:112685334(+) A-I      intronic chr10:112761523(+) A-I      intronic chr10:112758031(+) A-I      intronic chr10:112685252(+) A-I      intronic chr10:112685345(+) A-I      intronic chr10:112736309(+) A-I      intronic chr10:112761692(+) A-I      intronic chr10:112720482(+) A-I      intronic chr10:112764791(+) A-I      intronic chr10:112685346(+) A-I      intronic chr10:112735055(+) A-I      intronic chr10:112684750(+) A-I      intronic chr10:112759280(+) A-I      intronic chr10:112685424(+) A-I      intronic chr10:112760972(+) A-I      intronic chr10:112720618(+) A-I      intronic chr10:112761759(+) A-I      intronic chr10:112684613(+) A-I      intronic chr10:112685453(+) A-I      intronic chr10:112684670(+) A-I      intronic chr10:112684669(+) A-I      intronic chr10:112761636(+) A-I      intronic chr10:112685492(+) A-I      intronic chr10:112685451(+) A-I      intronic chr10:112699076(+) A-I      intronic chr10:112685450(+) A-I      intronic chr10:112685444(+) A-I      intronic chr10:112764790(+) A-I      intronic chr10:112685458(+) A-I      intronic chr10:112685435(+) A-I      intronic chr10:112685437(+) A-I      intronic chr10:112732369(+) A-I      intronic chr10:112702183(+) A-I      intronic chr10:112684590(+) A-I      intronic chr10:112759294(+) A-I      intronic chr10:112687872(+) A-I      intronic chr10:112699187(+) A-I      intronic chr10:112684570(+) A-I      intronic chr10:112685405(+) A-I      intronic chr10:112685315(+) A-I      intronic chr10:112684677(+) A-I      intronic chr10:112684618(+) A-I      intronic chr10:112684679(+) A-I      intronic chr10:112728450(+) A-I      intronic chr10:112699199(+) A-I      intronic chr10:112684682(+) A-I      intronic chr10:112764860(+) A-I      intronic chr10:112761095(+) A-I      intronic chr10:112685381(+) A-I      intronic chr10:112759279(+) A-I      intronic chr10:112685356(+) A-I      intronic chr10:112685380(+) A-I      intronic chr10:112685316(+) A-I      intronic chr10:112685489(+) A-I      intronic chr10:112696792(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SHOC2	chr10:112696792(+) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SHOC2	chr10:112679797-112679798(+) m6A exon//intron       24981863 chr10:112723884-112723885(+) m6A 5'UTR//exon//intron       24981863 chr10:112724144-112724145(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:112724241-112724242(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:112724248-112724249(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:112724282-112724283(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:112724342-112724343(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:112724356-112724357(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:112724432-112724433(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:112724496-112724497(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:112724655-112724656(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:112724744-112724745(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr10:112724753-112724754(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr10:112724763-112724764(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr10:112724789-112724790(+) m6A CDS//exon//intron       24284625//24981863//22575960//22608085 chr10:112724799-112724800(+) m6A CDS//exon//intron       24284625//24981863//22575960//22608085 chr10:112745434-112745435(+) m6A CDS//exon//intron       22608085 chr10:112745457-112745458(+) m6A CDS//exon//intron       22608085 chr10:112745497-112745498(+) m6A CDS//exon//intron       - chr10:112745505-112745506(+) m6A CDS//exon//intron       - chr10:112771475-112771476(+) m6A CDS       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-2110	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	SHOC2	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-2110
Interactor2: SHOC2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.