Basic Information:

  VIRBase ID:  

HHID00071584

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-2110:  MIMAT0010133          ATP6V0A1:  NM_005177     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-2110	ATP6V0A1
miRBase Accession/Entrez ID	MIMAT0010133	535
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	a1//ATP6N1//ATP6N1A//Stv1//Vph1//VPP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-2110	rs114530801 chr10:114174163    G/A rs114530801 chr10:114174163    G/C rs114530801 chr10:114174163    G/T rs1168982220 chr10:114174162    C/G rs1188283086 chr10:114174156    A/T rs1246581316 chr10:114174158    C/T rs1412803607 chr10:114174164    T/A rs1431021422 chr10:114174157    G/C rs1476834649 chr10:114174154    TCAG/T rs192664871 chr10:114174154    T/C rs192664871 chr10:114174154    T/G rs573692968 chr10:114174159    G/A rs573692968 chr10:114174159    G/C rs755562830 chr10:114174148    CCTCA/C rs1178383827 chr10:114174165    T/G rs1418383763 chr10:114174167    C/T rs1434681640 chr10:114174169    C/T rs745914474 chr10:114174166    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATP6V0A1	chr17:40663438(+) A-I      intronic chr17:40653997(+) A-I      intronic chr17:40653980(+) A-I      intronic chr17:40626295(+) A-I      intronic chr17:40623052(+) A-I      intronic chr17:40663376(+) A-I      intronic chr17:40663387(+) A-I      intronic chr17:40663432(+) A-I      intronic chr17:40626150(+) A-I      intronic chr17:40672310(+) A-I      intronic chr17:40636961(+) A-I      intronic chr17:40637051(+) A-I      intronic chr17:40637077(+) A-I      intronic chr17:40637694(+) A-I      intronic chr17:40637764(+) A-I      intronic chr17:40638267(+) A-I      intronic chr17:40638282(+) A-I      intronic chr17:40638308(+) A-I      intronic chr17:40638322(+) A-I      intronic chr17:40638384(+) A-I      intronic chr17:40638399(+) A-I      intronic chr17:40639661(+) A-I      intronic chr17:40639706(+) A-I      intronic chr17:40642824(+) A-I      intronic chr17:40642836(+) A-I      intronic chr17:40642846(+) A-I      intronic chr17:40643456(+) A-I      intronic chr17:40643571(+) A-I      intronic chr17:40643576(+) A-I      intronic chr17:40643763(+) A-I      intronic chr17:40644225(+) A-I      intronic chr17:40657123(+) A-I      intronic chr17:40644240(+) A-I      intronic chr17:40644319(+) A-I      intronic chr17:40653513(+) A-I      intronic chr17:40653598(+) A-I      intronic chr17:40653613(+) A-I      intronic chr17:40633960(+) A-I      intronic chr17:40633680(+) A-I      intronic chr17:40633923(+) A-I      intronic chr17:40633989(+) A-I      intronic chr17:40634098(+) A-I      intronic chr17:40634264(+) A-I      intronic chr17:40653772(+) A-I      intronic chr17:40634699(+) A-I      intronic chr17:40634714(+) A-I      intronic chr17:40634729(+) A-I      intronic chr17:40634737(+) A-I      intronic chr17:40634756(+) A-I      intronic chr17:40634772(+) A-I      intronic chr17:40634800(+) A-I      intronic chr17:40636916(+) A-I      intronic chr17:40624213(+) A-I      intronic chr17:40654067(+) A-I      intronic chr17:40653856(+) A-I      intronic chr17:40657140(+) A-I      intronic chr17:40653865(+) A-I      intronic chr17:40653891(+) A-I      intronic chr17:40653899(+) A-I      intronic chr17:40654001(+) A-I      intronic chr17:40614038(+) A-I      intronic chr17:40614178(+) A-I      intronic chr17:40614531(+) A-I      intronic chr17:40614538(+) A-I      intronic chr17:40614555(+) A-I      intronic chr17:40615278(+) A-I      intronic chr17:40616538(+) A-I      intronic chr17:40616603(+) A-I      intronic chr17:40616606(+) A-I      intronic chr17:40617878(+) A-I      intronic chr17:40617905(+) A-I      intronic chr17:40623026(+) A-I      intronic chr17:40623035(+) A-I      intronic chr17:40623051(+) A-I      intronic chr17:40623192(+) A-I      intronic chr17:40623222(+) A-I      intronic chr17:40623574(+) A-I      intronic chr17:40623592(+) A-I      intronic chr17:40623599(+) A-I      intronic chr17:40624146(+) A-I      intronic chr17:40624151(+) A-I      intronic chr17:40624152(+) A-I      intronic chr17:40624175(+) A-I      intronic chr17:40650659(+) A-I      intronic chr17:40624227(+) A-I      intronic chr17:40624272(+) A-I      intronic chr17:40624478(+) A-I      intronic chr17:40624595(+) A-I      intronic chr17:40624599(+) A-I      intronic chr17:40626138(+) A-I      intronic chr17:40626182(+) A-I      intronic chr17:40626262(+) A-I      intronic chr17:40633502(+) A-I      intronic chr17:40633509(+) A-I      intronic chr17:40633607(+) A-I      intronic chr17:40633628(+) A-I      intronic chr17:40643817(+) A-I      intronic chr17:40623106(+) A-I      intronic chr17:40614567(+) A-I      intronic chr17:40617824(+) A-I      intronic chr17:40624355(+) A-I      intronic chr17:40616587(+) A-I      intronic chr17:40623123(+) A-I      intronic chr17:40623020(+) A-I      intronic chr17:40613607(+) A-I      intronic chr17:40637025(+) A-I      intronic chr17:40614541(+) A-I      intronic chr17:40653892(+) A-I      intronic chr17:40654002(+) A-I      intronic chr17:40644328(+) A-I      intronic chr17:40657157(+) A-I      intronic chr17:40624171(+) A-I      intronic chr17:40638243(+) A-I      intronic chr17:40653519(+) A-I      intronic chr17:40617582(+) A-I      intronic chr17:40657875(+) A-I      intronic chr17:40640602(+) A-I      intronic chr17:40653910(+) A-I      intronic chr17:40623576(+) A-I      intronic chr17:40623677(+) A-I      intronic chr17:40624485(+) A-I      intronic chr17:40617823(+) A-I      intronic chr17:40623379(+) A-I      intronic chr17:40631208(+) A-I      intronic chr17:40616704(+) A-I      intronic chr17:40643775(+) A-I      intronic chr17:40616451(+) A-I      intronic chr17:40613535(+) A-I      intronic chr17:40623319(+) A-I      intronic chr17:40637033(+) A-I      intronic chr17:40644201(+) A-I      intronic chr17:40623672(+) A-I      intronic chr17:40626147(+) A-I      intronic chr17:40633375(+) A-I      intronic chr17:40658035(+) A-I      intronic chr17:40637785(+) A-I      intronic chr17:40621478(+) A-I      intronic chr17:40623293(+) A-I      intronic chr17:40648050(+) A-I      intronic chr17:40658068(+) A-I      intronic chr17:40617727(+) A-I      intronic chr17:40624622(+) A-I      intronic chr17:40633591(+) A-I      intronic chr17:40621066(+) A-I      intronic chr17:40640935(+) A-I      intronic chr17:40640922(+) A-I      intronic chr17:40653536(+) A-I      intronic chr17:40653866(+) A-I      intronic chr17:40624307(+) A-I      intronic chr17:40653931(+) A-I      intronic chr17:40626120(+) A-I      intronic chr17:40623093(+) A-I      intronic chr17:40646780(+) A-I      intronic chr17:40653789(+) A-I      intronic chr17:40623261(+) A-I      intronic chr17:40624158(+) A-I      intronic chr17:40623136(+) A-I      intronic chr17:40623361(+) A-I      intronic chr17:40644266(+) A-I      intronic chr17:40626204(+) A-I      intronic chr17:40645784(+) A-I      intronic chr17:40623144(+) A-I      intronic chr17:40649962(+) A-I      intronic chr17:40617286(+) A-I      intronic chr17:40650121(+) A-I      intronic chr17:40614152(+) A-I      intronic chr17:40626231(+) A-I      intronic chr17:40614153(+) A-I      intronic chr17:40624479(+) A-I      intronic chr17:40642840(+) A-I      intronic chr17:40617939(+) A-I      intronic chr17:40637007(+) A-I      intronic chr17:40624687(+) A-I      intronic chr17:40653900(+) A-I      intronic chr17:40626186(+) A-I      intronic chr17:40624097(+) A-I      intronic chr17:40624255(+) A-I      intronic chr17:40626293(+) A-I      intronic chr17:40653662(+) A-I      intronic chr17:40615124(+) A-I      intronic chr17:40633373(+) A-I      intronic chr17:40623428(+) A-I      intronic chr17:40653905(+) A-I      intronic chr17:40638349(+) A-I      intronic chr17:40624165(+) A-I      intronic chr17:40624334(+) A-I      intronic chr17:40614043(+) A-I      intronic chr17:40631125(+) A-I      intronic chr17:40623739(+) A-I      intronic chr17:40643180(+) A-I      intronic chr17:40623236(+) A-I      intronic chr17:40617820(+) A-I      intronic chr17:40623600(+) A-I      intronic chr17:40643526(+) A-I      intronic chr17:40624631(+) A-I      intronic chr17:40623235(+) A-I      intronic chr17:40623575(+) A-I      intronic chr17:40634304(+) A-I      intronic chr17:40626162(+) A-I      intronic chr17:40653887(+) A-I      intronic chr17:40624662(+) A-I      intronic chr17:40653874(+) A-I      intronic chr17:40633676(+) A-I      intronic chr17:40613537(+) A-I      intronic chr17:40633514(+) A-I      intronic chr17:40633333(+) A-I      intronic chr17:40624348(+) A-I      intronic chr17:40657158(+) A-I      intronic chr17:40613538(+) A-I      intronic chr17:40623086(+) A-I      intronic chr17:40633964(+) A-I      intronic chr17:40623641(+) A-I      intronic chr17:40624136(+) A-I      intronic chr17:40626206(+) A-I      intronic chr17:40615138(+) A-I      intronic chr17:40623697(+) A-I      intronic chr17:40645752(+) A-I      intronic chr17:40626160(+) A-I      intronic chr17:40637068(+) A-I      intronic chr17:40613992(+) A-I      intronic chr17:40641279(+) A-I      intronic chr17:40653661(+) A-I      intronic chr17:40623684(+) A-I      intronic chr17:40640509(+) A-I      intronic chr17:40634069(+) A-I      intronic chr17:40636023(+) A-I      intronic chr17:40616683(+) A-I      intronic chr17:40624294(+) A-I      intronic chr17:40623497(+) A-I      intronic chr17:40624648(+) A-I      intronic chr17:40653972(+) A-I      intronic chr17:40624172(+) A-I      intronic chr17:40657187(+) A-I      intronic chr17:40614041(+) A-I      intronic chr17:40639535(+) A-I      intronic chr17:40624103(+) A-I      intronic chr17:40623021(+) A-I      intronic chr17:40613963(+) A-I      intronic chr17:40617488(+) A-I      intronic chr17:40616695(+) A-I      intronic chr17:40613615(+) A-I      intronic chr17:40640529(+) A-I      intronic chr17:40653533(+) A-I      intronic chr17:40667364(+) A-I      intronic chr17:40639615(+) A-I      intronic chr17:40644962(+) A-I      intronic chr17:40657989(+) A-I      intronic chr17:40644302(+) A-I      intronic chr17:40657986(+) A-I      intronic chr17:40624281(+) A-I      intronic chr17:40623286(+) A-I      intronic chr17:40617448(+) A-I      intronic chr17:40653941(+) A-I      intronic chr17:40638175(+) A-I      intronic chr17:40653616(+) A-I      intronic chr17:40635729(+) A-I      intronic chr17:40653978(+) A-I      intronic chr17:40621075(+) A-I      intronic chr17:40635565(+) A-I      intronic chr17:40649113(+) A-I      intronic chr17:40624096(+) A-I      intronic chr17:40614462(+) A-I      intronic chr17:40624189(+) A-I      intronic chr17:40617150(+) A-I      intronic chr17:40626224(+) A-I      intronic chr17:40623550(+) A-I      intronic chr17:40626271(+) A-I      intronic chr17:40623545(+) A-I      intronic chr17:40653993(+) A-I      intronic chr17:40635555(+) A-I      intronic chr17:40623631(+) A-I      intronic chr17:40653890(+) A-I      intronic chr17:40617837(+) A-I      intronic chr17:40622989(+) A-I      intronic chr17:40637604(+) A-I      intronic chr17:40653532(+) A-I      intronic chr17:40626281(+) A-I      intronic chr17:40634754(+) A-I      intronic chr17:40624300(+) A-I      intronic chr17:40658040(+) A-I      intronic chr17:40653526(+) A-I      intronic chr17:40633503(+) A-I      intronic chr17:40643579(+) A-I      intronic chr17:40653881(+) A-I      intronic chr17:40624654(+) A-I      intronic chr17:40653961(+) A-I      intronic chr17:40624233(+) A-I      intronic chr17:40653599(+) A-I      intronic chr17:40614836(+) A-I      intronic chr17:40623587(+) A-I      intronic chr17:40626121(+) A-I      intronic chr17:40617965(+) A-I      intronic chr17:40623329(+) A-I      intronic chr17:40653550(+) A-I      intronic chr17:40623655(+) A-I      intronic chr17:40657131(+) A-I      intronic chr17:40623227(+) A-I      intronic chr17:40624261(+) A-I      intronic chr17:40637784(+) A-I      intronic chr17:40623422(+) A-I      intronic chr17:40644308(+) A-I      intronic chr17:40654035(+) A-I      intronic chr17:40653590(+) A-I      intronic chr17:40636282(+) A-I      intronic chr17:40631163(+) A-I      intronic chr17:40623707(+) A-I      intronic chr17:40653607(+) A-I      intronic chr17:40638176(+) A-I      intronic chr17:40633081(+) A-I      intronic chr17:40634310(+) A-I      intronic chr17:40626222(+) A-I      intronic chr17:40653842(+) A-I      intronic chr17:40622985(+) A-I      intronic chr17:40653896(+) A-I      intronic chr17:40624663(+) A-I      intronic chr17:40626101(+) A-I      intronic chr17:40631204(+) A-I      intronic chr17:40617264(+) A-I      intronic chr17:40663488(+) A-I      intronic chr17:40626125(+) A-I      intronic chr17:40653837(+) A-I      intronic chr17:40617280(+) A-I      intronic chr17:40623030(+) A-I      intronic chr17:40624166(+) A-I      intronic chr17:40624319(+) A-I      intronic chr17:40622994(+) A-I      intronic chr17:40623333(+) A-I      intronic chr17:40653894(+) A-I      intronic chr17:40637708(+) A-I      intronic chr17:40640628(+) A-I      intronic chr17:40615288(+) A-I      intronic chr17:40614458(+) A-I      intronic chr17:40644916(+) A-I      intronic chr17:40624201(+) A-I      intronic chr17:40622988(+) A-I      intronic chr17:40634088(+) A-I      intronic chr17:40615294(+) A-I      intronic chr17:40653638(+) A-I      intronic chr17:40644971(+) A-I      intronic chr17:40638309(+) A-I      intronic chr17:40644016(+) A-I      intronic chr17:40624211(+) A-I      intronic chr17:40624635(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATP6V0A1	chr17:40622912(+) A-I intron -    15342557   //15258596 chr17:40622931(+) A-I intron -    15342557 chr17:40622934(+) A-I intron -    15342557 chr17:40622945(+) A-I intron -    15342557   //15258596 chr17:40622965(+) A-I intron -    15342557   //15258596 chr17:40622976(+) A-I intron -    15342557   //15258596 chr17:40622979(+) A-I intron -    15342557   //15258596 chr17:40622985(+) A-I intron -    15342557   //15258596 chr17:40622988(+) A-I intron -    15342557   //15258596 chr17:40622989(+) A-I intron -    15342557   //15258596 chr17:40622991(+) A-I intron -    15342557   //15258596 chr17:40622994(+) A-I intron -    15342557   //15258596 chr17:40623020(+) A-I intron -    15342557   //15258596 chr17:40623021(+) A-I intron -    15342557   //15258596 chr17:40623030(+) A-I intron -    15342557   //15258596 chr17:40623106(+) A-I intron -    15342557   //15258596 chr17:40623136(+) A-I intron -    15342557   //15258596 chr17:40623227(+) A-I intron -    15342557   //15258596 chr17:40623235(+) A-I intron -    15342557   //15258596 chr17:40623236(+) A-I intron -    15342557   //15258596 chr17:40623286(+) A-I intron -    15342557   //15258596 chr17:40623293(+) A-I intron -    15342557 chr17:40623319(+) A-I intron -    15342557 chr17:40623329(+) A-I intron -    15342557 chr17:40623333(+) A-I intron -    15342557 chr17:40623361(+) A-I intron -    15342557 chr17:40623379(+) A-I intron -    15342557 chr17:40623422(+) A-I intron -    15342557 chr17:40622979(+) A-G intron -    22484847 chr17:40623020(+) A-G intron -    22484847 chr17:40623021(+) A-G intron -    22484847 chr17:40624662(+) A-G intron -    22484847 chr17:40626204(+) A-G intron -    22484847 chr17:40653842(+) A-G intron -    22484847 chr17:40653910(+) A-G intron -    22484847 chr17:40653408(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATP6V0A1	chr17:40629754-40629755(+) m6A 3'UTR//CDS//exon//intron       - chr17:40630584-40630585(+) m6A CDS//exon//intron       - chr17:40642506-40642507(+) m6A 5'UTR//CDS//exon       - chr17:40642538-40642539(+) m6A 5'UTR//CDS//exon       - chr17:40642549-40642550(+) m6A CDS//exon       - chr17:40642558-40642559(+) m6A CDS//exon       - chr17:40659540-40659541(+) m6A CDS//exon       - chr17:40659575-40659576(+) m6A CDS//exon       - chr17:40662531-40662532(+) m6A intron       - chr17:40662564-40662565(+) m6A intron       - chr17:40670502-40670503(+) m6A exon//intron       - chr17:40670515-40670516(+) m6A exon//intron       - chr17:40670543-40670544(+) m6A exon//intron       - chr17:40673075-40673076(+) m6A CDS//exon       - chr17:40673393-40673394(+) m6A 3'UTR//exon       - chr17:40673683-40673684(+) m6A 3'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-2110	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	ATP6V0A1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-2110
Interactor2: ATP6V0A1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.