Basic Information:

  VIRBase ID:  

HHID00071467

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          PAPOLA:  NM_001363665     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	PAPOLA
miRBase Accession/Entrez ID	MIMAT0009199	10914
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PAP//PAP-alpha

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PAPOLA	chr14:97028491(+) A-I      intronic chr14:97028503(+) A-I      intronic chr14:96995872(+) A-I      intronic chr14:96980717(+) A-I      intronic chr14:96992809(+) A-I      intronic chr14:96995902(+) A-I      intronic chr14:96988817(+) A-I      intronic chr14:96996793(+) A-I      intronic chr14:96991941(+) A-I      intronic chr14:96991967(+) A-I      intronic chr14:97028490(+) A-I      intronic chr14:96985229(+) A-I      intronic chr14:96972438(+) A-I      intronic chr14:96991010(+) A-I      intronic chr14:97019979(+) A-I      intronic chr14:96970875(+) A-I      intronic chr14:97000097(+) A-I      intronic chr14:97019600(+) A-I      intronic chr14:96996008(+) A-I      intronic chr14:97015792(+) A-I      intronic chr14:96975402(+) A-I      intronic chr14:96996911(+) A-I      intronic chr14:96996000(+) A-I      intronic chr14:97019697(+) A-I      intronic chr14:96970917(+) A-I      intronic chr14:97019727(+) A-I      intronic chr14:96995912(+) A-I      intronic chr14:96970784(+) A-I      intronic chr14:97019588(+) A-I      intronic chr14:96996759(+) A-I      intronic chr14:96996824(+) A-I      intronic chr14:96995980(+) A-I      intronic chr14:96990907(+) A-I      intronic chr14:96997419(+) A-I      intronic chr14:96972341(+) A-I      intronic chr14:97020058(+) A-I      intronic chr14:96985351(+) A-I      intronic chr14:96988036(+) A-I      intronic chr14:96988368(+) A-I      intronic chr14:96988860(+) A-I      intronic chr14:96988902(+) A-I      intronic chr14:96988942(+) A-I      intronic chr14:96990084(+) A-I      intronic chr14:96990090(+) A-I      intronic chr14:96990160(+) A-I      intronic chr14:96990201(+) A-I      intronic chr14:97019805(+) A-I      intronic chr14:96990212(+) A-I      intronic chr14:96990225(+) A-I      intronic chr14:96990880(+) A-I      intronic chr14:96990884(+) A-I      intronic chr14:96991984(+) A-I      intronic chr14:96994987(+) A-I      intronic chr14:96996836(+) A-I      intronic chr14:96995782(+) A-I      intronic chr14:96995804(+) A-I      intronic chr14:96990028(+) A-I      intronic chr14:96995805(+) A-I      intronic chr14:96995871(+) A-I      intronic chr14:96988084(+) A-I      intronic chr14:96985160(+) A-I      intronic chr14:96995896(+) A-I      intronic chr14:96995904(+) A-I      intronic chr14:96997395(+) A-I      intronic chr14:96995944(+) A-I      intronic chr14:96995965(+) A-I      intronic chr14:97019906(+) A-I      intronic chr14:96997245(+) A-I      intronic chr14:96987961(+) A-I      intronic chr14:96997456(+) A-I      intronic chr14:96988916(+) A-I      intronic chr14:96990224(+) A-I      intronic chr14:96996962(+) A-I      intronic chr14:96996823(+) A-I      intronic chr14:96995988(+) A-I      intronic chr14:96996046(+) A-I      intronic chr14:96997469(+) A-I      intronic chr14:96997480(+) A-I      intronic chr14:97019568(+) A-I      intronic chr14:96977716(+) A-I      intronic chr14:96997488(+) A-I      intronic chr14:97019696(+) A-I      intronic chr14:96997491(+) A-I      intronic chr14:96997515(+) A-I      intronic chr14:96995938(+) A-I      intronic chr14:96997524(+) A-I      intronic chr14:96997549(+) A-I      intronic chr14:96997711(+) A-I      intronic chr14:96997253(+) A-I      intronic chr14:96988050(+) A-I      intronic chr14:97019793(+) A-I      intronic chr14:96990970(+) A-I      intronic chr14:97019668(+) A-I      intronic chr14:96985139(+) A-I      intronic chr14:97019651(+) A-I      intronic chr14:96995916(+) A-I      intronic chr14:96997182(+) A-I      intronic chr14:96970918(+) A-I      intronic chr14:96997658(+) A-I      intronic chr14:96996009(+) A-I      intronic chr14:97016308(+) A-I      intronic chr14:96972380(+) A-I      intronic chr14:97019512(+) A-I      intronic chr14:96979561(+) A-I      intronic chr14:96991961(+) A-I      intronic chr14:96987957(+) A-I      intronic chr14:96972421(+) A-I      intronic chr14:97019601(+) A-I      intronic chr14:96972267(+) A-I      intronic chr14:96985339(+) A-I      intronic chr14:96997545(+) A-I      intronic chr14:96990027(+) A-I      intronic chr14:97019737(+) A-I      intronic chr14:96997694(+) A-I      intronic chr14:97019434(+) A-I      intronic chr14:96991968(+) A-I      intronic chr14:96996592(+) A-I      intronic chr14:96990070(+) A-I      intronic chr14:96995796(+) A-I      intronic chr14:96997326(+) A-I      intronic chr14:96997252(+) A-I      intronic chr14:97019813(+) A-I      intronic chr14:96996864(+) A-I      intronic chr14:96970958(+) A-I      intronic chr14:97023649(+) A-I      intronic chr14:96990071(+) A-I      intronic chr14:96996909(+) A-I      intronic chr14:96996854(+) A-I      intronic chr14:96995899(+) A-I      intronic chr14:97019654(+) A-I      intronic chr14:96985517(+) A-I      intronic chr14:96992787(+) A-I      intronic chr14:97019483(+) A-I      intronic chr14:96988197(+) A-I      intronic chr14:96988044(+) A-I      intronic chr14:97016364(+) A-I      intronic chr14:97019640(+) A-I      intronic chr14:96988956(+) A-I      intronic chr14:97019630(+) A-I      intronic chr14:97030563(+) A-I      intronic chr14:97019517(+) A-I      intronic chr14:96995952(+) A-I      intronic chr14:97019900(+) A-I      intronic chr14:96995857(+) A-I      intronic chr14:96995856(+) A-I      intronic chr14:97020083(+) A-I      intronic chr14:96997478(+) A-I      intronic chr14:96997390(+) A-I      intronic chr14:96985376(+) A-I      intronic chr14:97016288(+) A-I      intronic chr14:96985138(+) A-I      intronic chr14:97019594(+) A-I      intronic chr14:96997650(+) A-I      intronic chr14:97019950(+) A-I      intronic chr14:96997522(+) A-I      intronic chr14:97019903(+) A-I      intronic chr14:97019469(+) A-I      intronic chr14:96989016(+) A-I      intronic chr14:96996851(+) A-I      intronic chr14:96985162(+) A-I      intronic chr14:96995897(+) A-I      intronic chr14:97000021(+) A-I      intronic chr14:96995882(+) A-I      intronic chr14:96997468(+) A-I      intronic chr14:96970762(+) A-I      intronic chr14:96970963(+) A-I      intronic chr14:96997521(+) A-I      intronic chr14:97030643(+) A-I      intronic chr14:97016235(+) A-I      intronic chr14:96997308(+) A-I      intronic chr14:96988180(+) A-I      intronic chr14:97019509(+) A-I      intronic chr14:96978635(+) A-I      intronic chr14:97028497(+) A-I      intronic chr14:97019522(+) A-I      intronic chr14:96991946(+) A-I      intronic chr14:97019741(+) A-I      intronic chr14:96997600(+) A-I      intronic chr14:96997609(+) A-I      intronic chr14:96984275(+) A-I      intronic chr14:96972415(+) A-I      intronic chr14:96997191(+) A-I      intronic chr14:97016441(+) A-I      intronic chr14:96997251(+) A-I      intronic chr14:97019649(+) A-I      intronic chr14:96997599(+) A-I      intronic chr14:97019595(+) A-I      intronic chr14:97019750(+) A-I      intronic chr14:96982895(+) A-I      intronic chr14:96972358(+) A-I      intronic chr14:96968767(+) A-I      5'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PAPOLA	chr14:96968767(+) A-I exon 5'UTR    19478186 chr14:96970918(+) A-I intron -    15258596 chr14:96970958(+) A-I intron -    15258596 chr14:96970963(+) A-I intron -    15258596 chr14:97019524(+) A-I intron -    15258596 chr14:97019601(+) A-I intron -    15258596   //22327324 chr14:97019654(+) A-I intron -    15258596 chr14:97019668(+) A-I intron -    15258596 chr14:97019741(+) A-I intron -    21960545   //22327324 chr14:96992787(+) A-I intron -    21960545 chr14:96996773(+) A-I intron -    21960545 chr14:97030643(+) A-I intron -    21960545 chr14:97019601(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PAPOLA	chr14:96967874-96967875(+) m6A exon       24981863//22608085 chr14:96968815-96968816(+) m6A 5'UTR//CDS//exon//intron       24209618//25456834//24981863//26404942//22575960//22608085 chr14:96969205-96969206(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr14:96970949-96970950(+) m6A exon//intron       - chr14:96971027-96971028(+) m6A exon//intron       26404942 chr14:96986419-96986420(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:96986482-96986483(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:96986505-96986506(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:97022188-97022189(+) m6A 3'UTR//CDS//exon       27773535 chr14:97022537-97022538(+) m6A 3'UTR//CDS       27773535 chr14:97022613-97022614(+) m6A 3'UTR//CDS       27773535 chr14:97022699-97022700(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97022735-97022736(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97022741-97022742(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97026828-97026829(+) m6A exon//intron       24981863//27773535 chr14:97026844-97026845(+) m6A exon//intron       24981863//27773535 chr14:97026981-97026982(+) m6A exon//intron       24284625 chr14:97026991-97026992(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97027026-97027027(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97027036-97027037(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97028798-97028799(+) m6A exon//intron       24284625 chr14:97029157-97029158(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//22608085 chr14:97029173-97029174(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr14:97029194-97029195(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr14:97029203-97029204(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr14:97031294-97031295(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:97031307-97031308(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:97031368-97031369(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr14:97031389-97031390(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031409-97031410(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031472-97031473(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031477-97031478(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031637-97031638(+) m6A 3'UTR       24284625//24981863//22608085 chr14:97032261-97032262(+) m6A 3'UTR       27773535 chr14:97032297-97032298(+) m6A 3'UTR       27773535 chr14:97033298-97033299(+) m6A 3'UTR       27773535 chr14:97033397-97033398(+) m6A 3'UTR       27773535 chr14:97033423-97033424(+) m6A 3'UTR       27773535 chr14:97033439-97033440(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	PAPOLA	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: PAPOLA

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.