Detail Information

Basic Information:


  VIRBase ID:  

HHID00071392

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           E2F2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p E2F2
miRBase
Accession/Entrez ID		 MIMAT0009199 1870
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - E2F-2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR E2F2
chr1:23839443(-) A-I      intronic
chr1:23839529(-) A-I      intronic
chr1:23840492(-) A-I      intronic
chr1:23849928(-) A-I      intronic
chr1:23842412(-) A-I      intronic
chr1:23838507(-) A-I      intronic
chr1:23840533(-) A-I      intronic
chr1:23840530(-) A-I      intronic
chr1:23840424(-) A-I      intronic
chr1:23839437(-) A-I      intronic
chr1:23838630(-) A-I      intronic
chr1:23837044(-) A-I      intronic
chr1:23836999(-) A-I      intronic
chr1:23836996(-) A-I      intronic
chr1:23836994(-) A-I      intronic
chr1:23836915(-) A-I      intronic
chr1:23841207(-) A-I      intronic
chr1:23841221(-) A-I      intronic
chr1:23842413(-) A-I      intronic
chr1:23836914(-) A-I      intronic
chr1:23837927(-) A-I      intronic
chr1:23842393(-) A-I      intronic
chr1:23839401(-) A-I      intronic
chr1:23836955(-) A-I      intronic
chr1:23841270(-) A-I      intronic
chr1:23839365(-) A-I      intronic
chr1:23840500(-) A-I      intronic
chr1:23841128(-) A-I      intronic
chr1:23842272(-) A-I      intronic
chr1:23837851(-) A-I      intronic
chr1:23841285(-) A-I      intronic
chr1:23839442(-) A-I      intronic
chr1:23837096(-) A-I      intronic
chr1:23839445(-) A-I      intronic
chr1:23841103(-) A-I      intronic
chr1:23839402(-) A-I      intronic
chr1:23837803(-) A-I      intronic
chr1:23841137(-) A-I      intronic
chr1:23850466(-) A-I      intronic
chr1:23841266(-) A-I      intronic
chr1:23839551(-) A-I      intronic
chr1:23838524(-) A-I      intronic
chr1:23842469(-) A-I      intronic
chr1:23840497(-) A-I      intronic
chr1:23839390(-) A-I      intronic
chr1:23849924(-) A-I      intronic
chr1:23839475(-) A-I      intronic
chr1:23840539(-) A-I      intronic
chr1:23842410(-) A-I      intronic
chr1:23838546(-) A-I      intronic
chr1:23842331(-) A-I      intronic
chr1:23838473(-) A-I      intronic
chr1:23839542(-) A-I      intronic
chr1:23842352(-) A-I      intronic
chr1:23837088(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED E2F2
chr1:23839445(-) A-I intron -    22327324
chr1:23837096(-) A-G intron -    22484847
chr1:23838473(-) A-G intron -    22484847
chr1:23839442(-) A-G intron -    22484847
chr1:23839445(-) A-G intron -    22484847
chr1:23840539(-) A-G intron -    22484847
chr1:23841103(-) A-G intron -    22484847
chr1:23841128(-) A-G intron -    22484847
chr1:23841137(-) A-G intron -    22484847
chr1:23841270(-) A-G intron -    22484847
chr1:23841285(-) A-G intron -    22484847
chr1:23842393(-) A-G intron -    22484847
chr1:23849924(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase E2F2
chr1:23835817-23835818(-) m6A 3'UTR       24284625
chr1:23836282-23836283(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr1:23836289-23836290(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr1:23836320-23836321(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr1:23836387-23836388(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr1:23836462-23836463(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr1:23836525-23836526(-) m6A CDS       24284625//24209618//25456834//27371828//27773536//22575960
chr1:23836532-23836533(-) m6A CDS       24284625//24209618//25456834//27371828//27773536//22575960
chr1:23842939-23842940(-) m6A CDS//exon       24284625//24981863//27371828//27773536
chr1:23845512-23845513(-) m6A CDS//exon       24284625//27371828
chr1:23845531-23845532(-) m6A CDS//exon       24284625//27371828
chr1:23845566-23845567(-) m6A CDS//exon       -
chr1:23845652-23845653(-) m6A exon//intron       -
chr1:23847467-23847468(-) m6A CDS       27371828
chr1:23847485-23847486(-) m6A CDS       27371828
chr1:23847532-23847533(-) m6A CDS       27371828
chr1:23847542-23847543(-) m6A CDS       27371828
chr1:23848343-23848344(-) m6A CDS       24284625
chr1:23848439-23848440(-) m6A CDS       24284625
chr1:23848445-23848446(-) m6A CDS       24284625
chr1:23848524-23848525(-) m6A CDS       24284625
chr1:23857342-23857343(-) m6A 5'UTR       27773536
chr1:23857528-23857529(-) m6A 5'UTR       27371828//27773536
chr1:23857591-23857592(-) m6A 5'UTR       27371828//27773536
chr1:23857613-23857614(-) m6A 5'UTR       25456834//24981863//27371828//27773536
chr1:23857670-23857671(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536
chr1:23857708-23857709(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
E2F2
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: E2F2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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