Basic Information:

  VIRBase ID:  

HHID00071379

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          ALAS1:  NM_001304444     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	ALAS1
miRBase Accession/Entrez ID	MIMAT0009199	211
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALAS//ALAS-H//ALAS3//ALASH//MIG4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ALAS1	chr3:52243317(+) A-I      intronic chr3:52243304(+) A-I      intronic chr3:52243293(+) A-I      intronic chr3:52243255(+) A-I      intronic chr3:52234021(+) A-I      intronic chr3:52243830(+) A-I      intronic chr3:52243389(+) A-I      intronic chr3:52243323(+) A-I      intronic chr3:52243333(+) A-I      intronic chr3:52244755(+) A-I      intronic chr3:52244736(+) A-I      intronic chr3:52244765(+) A-I      intronic chr3:52244783(+) A-I      intronic chr3:52244738(+) A-I      intronic chr3:52244527(+) A-I      intronic chr3:52244782(+) A-I      intronic chr3:52244535(+) A-I      intronic chr3:52244520(+) A-I      intronic chr3:52244605(+) A-I      intronic chr3:52244564(+) A-I      intronic chr3:52244626(+) A-I      intronic chr3:52244576(+) A-I      intronic chr3:52244750(+) A-I      intronic chr3:52244647(+) A-I      intronic chr3:52244744(+) A-I      intronic chr3:52244529(+) A-I      intronic chr3:52233977(+) A-I      intronic chr3:52243430(+) A-I      intronic chr3:52244720(+) A-I      intronic chr3:52243905(+) A-I      intronic chr3:52243861(+) A-I      intronic chr3:52244715(+) A-I      intronic chr3:52243762(+) A-I      intronic chr3:52243764(+) A-I      intronic chr3:52241280(+) A-I      intronic chr3:52243796(+) A-I      intronic chr3:52244680(+) A-I      intronic chr3:52244704(+) A-I      intronic chr3:52243795(+) A-I      intronic chr3:52243808(+) A-I      intronic chr3:52244811(+) A-I      intronic chr3:52244557(+) A-I      intronic chr3:52233918(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ALAS1	chr3:52244710(+) A-I intron -    22327324 chr3:52244522(+) A-I intron -    21960545 chr3:52233931(+) A-G intron -    22484847 chr3:52233983(+) A-G intron -    22484847 chr3:52243808(+) A-G intron -    22484847 chr3:52244522(+) A-G intron -    22484847 chr3:52244529(+) A-G intron -    22484847 chr3:52244626(+) A-G intron -    22484847 chr3:52244710(+) A-G intron -    22484847 chr3:52244720(+) A-G intron -    22484847 chr3:52244744(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ALAS1	chr3:52232188-52232189(+) m6A 5'UTR       24284625//24981863//22608085 chr3:52232214-52232215(+) m6A 5'UTR       24284625//24981863 chr3:52232714-52232715(+) m6A 5'UTR//intron       24284625//24981863 chr3:52232745-52232746(+) m6A 5'UTR//intron       24284625 chr3:52232752-52232753(+) m6A 5'UTR//intron       24284625 chr3:52232762-52232763(+) m6A 5'UTR//intron       24284625 chr3:52232792-52232793(+) m6A 5'UTR//intron       24284625 chr3:52233255-52233256(+) m6A 5'UTR       24284625 chr3:52240614-52240615(+) m6A CDS       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	ALAS1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: ALAS1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.