Basic Information:

  VIRBase ID:  

HHID00071282

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-103a-2-5p:  MIMAT0009196          MTHFD2:  NR_027405     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-103a-2-5p	MTHFD2
miRBase Accession/Entrez ID	MIMAT0009196	10797
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NMDMC

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-103a-2-5p	rs1315599005 chr20:3917515    A/G rs1319257633 chr20:3917504    A/G rs766345821 chr20:3917522    C/T rs1201044934 chr20:3917509    C/CTG

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MTHFD2	chr2:74434854(+) A-I      NonSyn:Lys->Glu chr2:74442816(+) A-I      3'UTR chr2:74434829(+) A-I      intronic chr2:74442835(+) A-I      3'UTR chr2:74434827(+) A-I      intronic chr2:74442810(+) A-I      3'UTR chr2:74442800(+) A-I      3'UTR chr2:74434824(+) A-I      intronic chr2:74442836(+) A-I      3'UTR chr2:74430672(+) A-I      intronic chr2:74430688(+) A-I      intronic chr2:74432022(+) A-I      intronic chr2:74430706(+) A-I      intronic chr2:74431060(+) A-I      intronic chr2:74430167(+) A-I      intronic chr2:74430147(+) A-I      intronic chr2:74430407(+) A-I      intronic chr2:74443004(+) A-I      3'UTR chr2:74430673(+) A-I      intronic chr2:74426760(+) A-I      intronic chr2:74429734(+) A-I      intronic chr2:74430691(+) A-I      intronic chr2:74431141(+) A-I      intronic chr2:74432014(+) A-I      intronic chr2:74430683(+) A-I      intronic chr2:74430674(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MTHFD2	chr2:74431060(+) A-I intron -    22327324 chr2:74426760(+) A-G intron -    22484847 chr2:74426832(+) C-A intron -    22484847 chr2:74426833(+) T-A intron -    22484847 chr2:74426834(+) C-A intron -    22484847 chr2:74428260(+) G-A intron -    22484847 chr2:74430407(+) A-G intron -    22484847 chr2:74430692(+) A-G intron -    22484847 chr2:74431060(+) A-G intron -    22484847 chr2:74431141(+) A-G intron -    22484847 chr2:74432014(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MTHFD2	chr2:74434900-74434901(+) m6A 3'UTR//CDS//exon//intron       22575960 chr2:74435737-74435738(+) m6A 3'UTR//CDS//exon//intron       22575960 chr2:74435844-74435845(+) m6A 3'UTR//CDS//exon//intron       22575960 chr2:74441392-74441393(+) m6A 3'UTR       26404942 chr2:74441621-74441622(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-103a-2-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	MTHFD2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-103a-2-5p
Interactor2: MTHFD2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.