Basic Information:

  VIRBase ID:  

HHID00071253

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-103a-2-5p:  MIMAT0009196          SH3BP2:  NM_003023     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-103a-2-5p	SH3BP2
miRBase Accession/Entrez ID	MIMAT0009196	6452
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	3BP-2//3BP2//CRBM//CRPM//RES4-23

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-103a-2-5p	rs1315599005 chr20:3917515    A/G rs1319257633 chr20:3917504    A/G rs766345821 chr20:3917522    C/T rs1201044934 chr20:3917509    C/CTG

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SH3BP2	chr4:2797152(+) A-I      intronic chr4:2841052(+) A-I      3'UTR chr4:2841737(+) A-I      3'UTR chr4:2841081(+) A-I      3'UTR chr4:2841061(+) A-I      3'UTR chr4:2841062(+) A-I      3'UTR chr4:2841726(+) A-I      3'UTR chr4:2841706(+) A-I      3'UTR chr4:2841703(+) A-I      3'UTR chr4:2841562(+) A-I      3'UTR chr4:2841538(+) A-I      3'UTR chr4:2841514(+) A-I      3'UTR chr4:2841502(+) A-I      3'UTR chr4:2841487(+) A-I      3'UTR chr4:2841480(+) A-I      3'UTR chr4:2841430(+) A-I      3'UTR chr4:2841381(+) A-I      3'UTR chr4:2841357(+) A-I      3'UTR chr4:2841339(+) A-I      3'UTR chr4:2841119(+) A-I      3'UTR chr4:2841118(+) A-I      3'UTR chr4:2841117(+) A-I      3'UTR chr4:2840995(+) A-I      3'UTR chr4:2841530(+) A-I      3'UTR chr4:2841461(+) A-I      3'UTR chr4:2841444(+) A-I      3'UTR chr4:2841412(+) A-I      3'UTR chr4:2841382(+) A-I      3'UTR chr4:2841317(+) A-I      3'UTR chr4:2841977(+) A-I      3'UTR chr4:2841071(+) A-I      3'UTR chr4:2841934(+) A-I      3'UTR chr4:2840978(+) A-I      3'UTR chr4:2841912(+) A-I      3'UTR chr4:2841897(+) A-I      3'UTR chr4:2841885(+) A-I      3'UTR chr4:2841781(+) A-I      3'UTR chr4:2841008(+) A-I      3'UTR chr4:2841037(+) A-I      3'UTR chr4:2841763(+) A-I      3'UTR chr4:2841043(+) A-I      3'UTR chr4:2841792(+) A-I      3'UTR chr4:2841793(+) A-I      3'UTR chr4:2841520(+) A-I      3'UTR chr4:2840963(+) A-I      3'UTR chr4:2841893(+) A-I      3'UTR chr4:2841787(+) A-I      3'UTR chr4:2841802(+) A-I      3'UTR chr4:2841751(+) A-I      3'UTR chr4:2841917(+) A-I      3'UTR chr4:2841102(+) A-I      3'UTR chr4:2841922(+) A-I      3'UTR chr4:2841697(+) A-I      3'UTR chr4:2841478(+) A-I      3'UTR chr4:2841513(+) A-I      3'UTR chr4:2841551(+) A-I      3'UTR chr4:2841434(+) A-I      3'UTR chr4:2841805(+) A-I      3'UTR chr4:2841791(+) A-I      3'UTR chr4:2841845(+) A-I      3'UTR chr4:2841800(+) A-I      3'UTR chr4:2841021(+) A-I      3'UTR chr4:2841527(+) A-I      3'UTR chr4:2841360(+) A-I      3'UTR chr4:2841837(+) A-I      3'UTR chr4:2841886(+) A-I      3'UTR chr4:2841753(+) A-I      3'UTR chr4:2841398(+) A-I      3'UTR chr4:2841790(+) A-I      3'UTR chr4:2841335(+) A-I      3'UTR chr4:2841319(+) A-I      3'UTR chr4:2841841(+) A-I      3'UTR chr4:2841035(+) A-I      3'UTR chr4:2841440(+) A-I      3'UTR chr4:2841394(+) A-I      3'UTR chr4:2840918(+) A-I      3'UTR chr4:2841571(+) A-I      3'UTR chr4:2841456(+) A-I      3'UTR chr4:2841859(+) A-I      3'UTR chr4:2841947(+) A-I      3'UTR chr4:2841388(+) A-I      3'UTR chr4:2841512(+) A-I      3'UTR chr4:2841396(+) A-I      3'UTR chr4:2841877(+) A-I      3'UTR chr4:2841831(+) A-I      3'UTR chr4:2840954(+) A-I      3'UTR chr4:2841567(+) A-I      3'UTR chr4:2841022(+) A-I      3'UTR chr4:2841320(+) A-I      3'UTR chr4:2841395(+) A-I      3'UTR chr4:2841025(+) A-I      3'UTR chr4:2841565(+) A-I      3'UTR chr4:2824226(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SH3BP2	chr4:2841388(+) A-I exon 3'UTR    15258596   //22028664   //21960545   //22327324 chr4:2841526(+) A-I exon 3'UTR    15258596 chr4:2841552(+) A-I exon 3'UTR    15258596   //21960545 chr4:2841553(+) A-I exon 3'UTR    15258596   //21960545 chr4:2841751(+) A-I exon 3'UTR    15258596 chr4:2841790(+) A-I exon 3'UTR    15258596 chr4:2841791(+) A-I exon 3'UTR    15258596 chr4:2841799(+) A-I exon 3'UTR    15258596 chr4:2841831(+) A-I exon 3'UTR    15258596   //22028664 chr4:2841837(+) A-I exon 3'UTR    15258596   //22028664   //22327324 chr4:2841841(+) A-I exon 3'UTR    15258596   //22028664 chr4:2841845(+) A-I exon 3'UTR    15258596   //22028664 chr4:2841886(+) A-I exon 3'UTR    15258596 chr4:2841352(+) A-I intron -    22028664   //21960545   //22327324 chr4:2841360(+) A-I intron -    22028664   //21960545   //22327324 chr4:2841396(+) A-I intron -    22028664   //21960545   //22327324 chr4:2841434(+) A-I intron -    21960545   //22327324 chr4:2841320(+) A-I intron -    22028664   //21960545 chr4:2841335(+) A-I intron -    22028664 chr4:2841394(+) A-I intron -    22028664 chr4:2841398(+) A-I intron -    22028664   //21960545 chr4:2841424(+) A-I intron -    22028664   //21960545 chr4:2841431(+) A-I intron -    22028664 chr4:2841440(+) A-I intron -    22028664 chr4:2841801(+) A-I intron -    22028664 chr4:2841805(+) A-I intron -    22028664 chr4:2841421(+) A-I intron -    21960545 chr4:2840963(+) A-I intron -    21960545 chr4:2841315(+) A-I intron -    21960545 chr4:2841456(+) A-I intron -    21960545 chr4:2841691(+) A-I intron -    21960545 chr4:2841698(+) A-I intron -    21960545 chr4:2841893(+) A-I intron -    21960545 chr4:2841553(+) A-G intron -    21725310   //22484847 chr4:2803760(+) G-A intron -    22484847 chr4:2804008(+) A-T intron -    22484847 chr4:2839005(+) C-A intron -    22484847 chr4:2839036(+) C-G intron -    22484847 chr4:2840942(+) T-A intron -    22484847 chr4:2840963(+) A-G intron -    22484847 chr4:2841021(+) A-G intron -    22484847 chr4:2841315(+) A-G intron -    22484847 chr4:2841320(+) A-G intron -    22484847 chr4:2841352(+) A-G intron -    22484847 chr4:2841359(+) A-G intron -    22484847 chr4:2841360(+) A-G intron -    22484847 chr4:2841388(+) A-G intron -    22484847 chr4:2841396(+) A-G intron -    22484847 chr4:2841398(+) A-G intron -    22484847 chr4:2841421(+) A-G intron -    22484847 chr4:2841424(+) A-G intron -    22484847 chr4:2841434(+) A-G intron -    22484847 chr4:2841436(+) A-G intron -    22484847 chr4:2841456(+) A-G intron -    22484847 chr4:2841462(+) T-A intron -    22484847 chr4:2841520(+) A-G intron -    22484847 chr4:2841552(+) A-G intron -    22484847 chr4:2841565(+) A-G intron -    22484847 chr4:2841567(+) A-G intron -    22484847 chr4:2841681(+) A-G intron -    22484847 chr4:2841691(+) A-G intron -    22484847 chr4:2841697(+) A-G intron -    22484847 chr4:2841787(+) A-G intron -    22484847 chr4:2841799(+) A-G intron -    22484847 chr4:2841801(+) A-G intron -    22484847 chr4:2841805(+) A-G intron -    22484847 chr4:2841831(+) A-G intron -    22484847 chr4:2841837(+) A-G intron -    22484847 chr4:2841841(+) A-G intron -    22484847 chr4:2841845(+) A-G intron -    22484847 chr4:2841947(+) A-G intron -    22484847 chr4:2841969(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SH3BP2	chr4:2813971-2813972(+) m6A 5'UTR//intron       - chr4:2814145-2814146(+) m6A 5'UTR//CDS//exon//intron       - chr4:2826594-2826595(+) m6A exon//intron       25456834 chr4:2828970-2828971(+) m6A 3'UTR//CDS//exon       - chr4:2828976-2828977(+) m6A 3'UTR//CDS//exon       - chr4:2829036-2829037(+) m6A 3'UTR//CDS//exon       24284625//24209618 chr4:2831390-2831391(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863 chr4:2831402-2831403(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863 chr4:2831511-2831512(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2831557-2831558(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2831621-2831622(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2831631-2831632(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2831661-2831662(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2831729-2831730(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2831757-2831758(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2833395-2833396(+) m6A 3'UTR//CDS//exon       24284625 chr4:2834737-2834738(+) m6A 3'UTR//CDS//exon       24284625 chr4:2834756-2834757(+) m6A 3'UTR//CDS//exon       24284625 chr4:2834802-2834803(+) m6A exon//intron       24284625 chr4:2835627-2835628(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2835691-2835692(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2835703-2835704(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2835744-2835745(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2835774-2835775(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr4:2835817-2835818(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr4:2835824-2835825(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr4:2835849-2835850(+) m6A 3'UTR//exon       24284625//25456834 chr4:2835855-2835856(+) m6A 3'UTR//exon       24284625//25456834 chr4:2835945-2835946(+) m6A 3'UTR//exon       24284625 chr4:2835963-2835964(+) m6A 3'UTR//exon       24284625 chr4:2836888-2836889(+) m6A 3'UTR       24284625 chr4:2836894-2836895(+) m6A 3'UTR       24284625 chr4:2836979-2836980(+) m6A 3'UTR       24284625 chr4:2837000-2837001(+) m6A 3'UTR       24284625 chr4:2837067-2837068(+) m6A 3'UTR       24284625 chr4:2837109-2837110(+) m6A 3'UTR       24284625 chr4:2837233-2837234(+) m6A 3'UTR       24284625 chr4:2838029-2838030(+) m1A 3'UTR       26863410 chr4:2838232-2838233(+) Y 3'UTR       26075521 chr4:2839344-2839345(+) m6A 3'UTR       - chr4:2839364-2839365(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-103a-2-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	SH3BP2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-103a-2-5p
Interactor2: SH3BP2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.