Basic Information:

  VIRBase ID:  

HHID00071232

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-103a-2-5p:  MIMAT0009196          IRF4:  NR_046000     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-103a-2-5p	IRF4
miRBase Accession/Entrez ID	MIMAT0009196	3662
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LSIRF//MUM1//NF-EM5//SHEP8

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-103a-2-5p	rs1315599005 chr20:3917515    A/G rs1319257633 chr20:3917504    A/G rs766345821 chr20:3917522    C/T rs1201044934 chr20:3917509    C/CTG

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IRF4	chr6:406463(+) A-I      intronic chr6:406474(+) A-I      intronic chr6:407708(+) A-I      3'UTR chr6:407778(+) A-I      3'UTR chr6:402790(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IRF4	chr6:400716(+) A-I intron -    22327324 chr6:402754(+) A-T intron -    22484847 chr6:402790(+) A-G intron -    22484847 chr6:402820(+) C-T intron -    22484847 chr6:402873(+) G-A intron -    22484847 chr6:402931(+) A-C intron -    22484847 chr6:402947(+) G-A intron -    22484847 chr6:402982(+) T-C intron -    22484847 chr6:406309(+) T-C intron -    22484847 chr6:406463(+) A-G intron -    22484847 chr6:406541(+) C-A intron -    22484847 chr6:407630(+) T-C intron -    22484847 chr6:407649(+) G-T intron -    22484847 chr6:407708(+) A-G intron -    22484847 chr6:407778(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IRF4	chr6:391773-391774(+) m6A 5'UTR//exon       27371828 chr6:393119-393120(+) m6A 5'UTR//intron       27371828 chr6:393156-393157(+) m6A CDS//intron       27371828 chr6:393333-393334(+) m6A CDS//exon//intron       26404942 chr6:394869-394870(+) m6A CDS//exon       26404942 chr6:394908-394909(+) m6A CDS//exon       26404942 chr6:394930-394931(+) m6A CDS//exon       26404942 chr6:394953-394954(+) m6A CDS//exon       26404942 chr6:394962-394963(+) m6A CDS//exon       26404942 chr6:395870-395871(+) m6A CDS//exon       - chr6:396003-396004(+) m6A exon//intron       - chr6:396018-396019(+) m6A exon//intron       - chr6:396026-396027(+) m6A exon//intron       - chr6:396065-396066(+) m6A exon//intron       - chr6:397153-397154(+) m6A CDS//exon       - chr6:397211-397212(+) m6A CDS//exon       - chr6:397485-397486(+) m6A exon//intron       - chr6:397516-397517(+) m6A exon//intron       - chr6:398844-398845(+) m6A CDS       - chr6:401514-401515(+) m6A CDS       26404942 chr6:401540-401541(+) m6A CDS       26404942 chr6:401567-401568(+) m6A CDS       26404942 chr6:401585-401586(+) m6A CDS       26404942 chr6:401661-401662(+) m6A CDS       26404942 chr6:401724-401725(+) m6A CDS       26404942 chr6:401735-401736(+) m6A CDS       26404942 chr6:401740-401741(+) m6A CDS       26404942 chr6:405095-405096(+) m6A CDS       - chr6:406875-406876(+) m6A 3'UTR//intron       - chr6:407459-407460(+) m6A 3'UTR//CDS       26404942 chr6:407474-407475(+) m6A 3'UTR//CDS       26404942 chr6:407500-407501(+) m6A 3'UTR//CDS       26404942 chr6:407507-407508(+) m6A 3'UTR//CDS       26404942 chr6:407537-407538(+) m6A 3'UTR//CDS       26404942 chr6:407742-407743(+) m6A 3'UTR       26404942 chr6:407806-407807(+) m6A 3'UTR       26404942 chr6:407929-407930(+) m6A 3'UTR       25456834//26404942 chr6:408015-408016(+) m6A 3'UTR       26404942 chr6:408116-408117(+) m6A 3'UTR       26404942 chr6:408125-408126(+) m6A 3'UTR       26404942 chr6:408275-408276(+) m6A 3'UTR       - chr6:408439-408440(+) m6A 3'UTR       - chr6:408464-408465(+) m6A 3'UTR       - chr6:408488-408489(+) m6A 3'UTR       - chr6:408616-408617(+) m6A 3'UTR       26404942 chr6:408636-408637(+) m6A 3'UTR       26404942 chr6:408755-408756(+) m6A 3'UTR       - chr6:408782-408783(+) m6A 3'UTR       - chr6:408818-408819(+) m6A 3'UTR       - chr6:409622-409623(+) m6A 3'UTR       26404942 chr6:409636-409637(+) m6A 3'UTR       26404942 chr6:409717-409718(+) m6A 3'UTR       26404942 chr6:410087-410088(+) m6A 3'UTR       26404942 chr6:410142-410143(+) m6A 3'UTR       26404942 chr6:410168-410169(+) m6A 3'UTR       26404942 chr6:410191-410192(+) m6A 3'UTR       26404942 chr6:410292-410293(+) m6A 3'UTR       26404942 chr6:410321-410322(+) m6A 3'UTR       26404942 chr6:410333-410334(+) m6A 3'UTR       26404942 chr6:410362-410363(+) m6A 3'UTR       26404942 chr6:410392-410393(+) m6A 3'UTR       26404942 chr6:410419-410420(+) m6A 3'UTR       26404942 chr6:410429-410430(+) m6A 3'UTR       26404942 chr6:410443-410444(+) m6A 3'UTR       26404942 chr6:410454-410455(+) m6A 3'UTR       26404942 chr6:411030-411031(+) m6A 3'UTR       26404942 chr6:411128-411129(+) m6A 3'UTR       26404942 chr6:411134-411135(+) m6A 3'UTR       26404942 chr6:411143-411144(+) m6A 3'UTR       26404942 chr6:411211-411212(+) m6A 3'UTR       26404942 chr6:411227-411228(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-103a-2-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	IRF4	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-103a-2-5p
Interactor2: IRF4

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.