Basic Information:

  VIRBase ID:  

HHID00071195

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1538:  MIMAT0007400          ZNF460:  NM_001330622     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1538	ZNF460
miRBase Accession/Entrez ID	MIMAT0007400	10794
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HZF8//ZNF272

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1538	rs1056432623 chr16:69565808    A/T rs1188596906 chr16:69565814    A/G rs1251934183 chr16:69565818    G/A rs1268793405 chr16:69565830    G/A rs1268793405 chr16:69565830    G/T rs1302764916 chr16:69565820    A/C rs1302764916 chr16:69565820    A/G rs1312567081 chr16:69565821    G/A rs1312567081 chr16:69565821    G/C rs1396563161 chr16:69565813    C/G rs1421950418 chr16:69565811    A/C rs1476031503 chr16:69565815    G/A rs1482881000 chr16:69565817    A/G rs917909479 chr16:69565816    C/A rs917909479 chr16:69565816    C/G rs1229814496 chr16:69565828    C/A rs1229814496 chr16:69565828    C/T rs1357756517 chr16:69565823    C/T rs376409664 chr16:69565825    G/A rs376409664 chr16:69565825    G/C rs376409664 chr16:69565825    G/T rs945480240 chr16:69565829    C/G rs950011608 chr16:69565826    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF460	chr19:57801829(+) A-I      intronic chr19:57795150(+) A-I      intronic chr19:57801881(+) A-I      intronic chr19:57794148(+) A-I      intronic chr19:57794156(+) A-I      intronic chr19:57795109(+) A-I      intronic chr19:57795144(+) A-I      intronic chr19:57798120(+) A-I      intronic chr19:57798143(+) A-I      intronic chr19:57798153(+) A-I      intronic chr19:57798154(+) A-I      intronic chr19:57799203(+) A-I      intronic chr19:57799207(+) A-I      intronic chr19:57799214(+) A-I      intronic chr19:57801121(+) A-I      intronic chr19:57801284(+) A-I      intronic chr19:57801353(+) A-I      intronic chr19:57801357(+) A-I      intronic chr19:57801428(+) A-I      intronic chr19:57801866(+) A-I      intronic chr19:57801826(+) A-I      intronic chr19:57801347(+) A-I      intronic chr19:57801528(+) A-I      intronic chr19:57801525(+) A-I      intronic chr19:57799226(+) A-I      intronic chr19:57801811(+) A-I      intronic chr19:57801785(+) A-I      intronic chr19:57801620(+) A-I      intronic chr19:57801541(+) A-I      intronic chr19:57794255(+) A-I      intronic chr19:57799657(+) A-I      intronic chr19:57801323(+) A-I      intronic chr19:57794103(+) A-I      intronic chr19:57801739(+) A-I      intronic chr19:57798144(+) A-I      intronic chr19:57794096(+) A-I      intronic chr19:57801763(+) A-I      intronic chr19:57795104(+) A-I      intronic chr19:57794212(+) A-I      intronic chr19:57794274(+) A-I      intronic chr19:57798877(+) A-I      intronic chr19:57794277(+) A-I      intronic chr19:57799307(+) A-I      intronic chr19:57799210(+) A-I      intronic chr19:57799640(+) A-I      intronic chr19:57794743(+) A-I      intronic chr19:57794638(+) A-I      intronic chr19:57801093(+) A-I      intronic chr19:57799594(+) A-I      intronic chr19:57798874(+) A-I      intronic chr19:57799277(+) A-I      intronic chr19:57795079(+) A-I      intronic chr19:57801527(+) A-I      intronic chr19:57799234(+) A-I      intronic chr19:57801294(+) A-I      intronic chr19:57794252(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF460	chr19:57794277(+) A-I intron -    22327324 chr19:57799640(+) A-I intron -    21960545 chr19:57799656(+) A-I intron -    21960545 chr19:57794277(+) A-G intron -    22484847 chr19:57801270(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF460	chr19:57792086-57792087(+) m6A 5'UTR//intron       24284625 chr19:57792132-57792133(+) m6A 5'UTR//intron       24284625 chr19:57793324-57793325(+) m6A 5'UTR//intron       - chr19:57796020-57796021(+) m6A CDS       24284625//24209618//22575960//22608085 chr19:57802079-57802080(+) m6A CDS       24284625//24209618//22575960//22608085 chr19:57802086-57802087(+) m6A CDS       24284625//24209618//22575960//22608085 chr19:57802142-57802143(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57802232-57802233(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57802239-57802240(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57802243-57802244(+) m6A CDS       25456834//24981863 chr19:57802259-57802260(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:57802283-57802284(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:57802333-57802334(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57802379-57802380(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57802535-57802536(+) m6A CDS       24284625//24981863//22575960//22608085 chr19:57802603-57802604(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:57802641-57802642(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:57802686-57802687(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:57802826-57802827(+) m6A CDS       24284625//22608085 chr19:57803125-57803126(+) m6A CDS       24284625//24981863//26404942//22608085 chr19:57803286-57803287(+) m6A CDS       24284625//24981863//22575960//22608085 chr19:57803293-57803294(+) m6A CDS       24284625//24981863//22575960//22608085 chr19:57803423-57803424(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57803583-57803584(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57803611-57803612(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57803705-57803706(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803740-57803741(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803768-57803769(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803798-57803799(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803866-57803867(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr19:57803894-57803895(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085 chr19:57803945-57803946(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr19:57803953-57803954(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804009-57804010(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:57804081-57804082(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804144-57804145(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804163-57804164(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804593-57804594(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804610-57804611(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804645-57804646(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804658-57804659(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804746-57804747(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1538	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ZNF460	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1538	Doxorubicin 31703 Drug interaction    RC00007908

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1538	Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1538
Interactor2: ZNF460

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.