Basic Information:

  VIRBase ID:  

HHID00071165

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          DDIAS:  NM_001363481     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	DDIAS
miRBase Accession/Entrez ID	MIMAT0006764	220042
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C11orf82//noxin

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DDIAS	chr11:82637201(+) A-I      intronic chr11:82637193(+) A-I      intronic chr11:82636542(+) A-I      intronic chr11:82636457(+) A-I      intronic chr11:82635812(+) A-I      intronic chr11:82637258(+) A-I      intronic chr11:82637232(+) A-I      intronic chr11:82637226(+) A-I      intronic chr11:82637257(+) A-I      intronic chr11:82639448(+) A-I      intronic chr11:82636951(+) A-I      intronic chr11:82636424(+) A-I      intronic chr11:82636437(+) A-I      intronic chr11:82636430(+) A-I      intronic chr11:82636489(+) A-I      intronic chr11:82637340(+) A-I      intronic chr11:82635583(+) A-I      intronic chr11:82635588(+) A-I      intronic chr11:82637331(+) A-I      intronic chr11:82635585(+) A-I      intronic chr11:82637405(+) A-I      intronic chr11:82636375(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DDIAS	chr11:82620301-82620302(+) m6A 5'UTR//intron       24981863 chr11:82642793-82642794(+) m6A CDS//exon       24284625//22608085 chr11:82642885-82642886(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr11:82642938-82642939(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr11:82642955-82642956(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr11:82643165-82643166(+) m6A 3'UTR//CDS//intron       24284625//24209618//22608085 chr11:82643197-82643198(+) m6A 3'UTR//CDS//intron       24284625//24209618//22608085 chr11:82643321-82643322(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82643749-82643750(+) m6A 3'UTR//CDS//intron       24981863 chr11:82643781-82643782(+) m6A 3'UTR//CDS//intron       24981863 chr11:82643845-82643846(+) m6A 3'UTR//CDS//intron       24981863 chr11:82644215-82644216(+) m6A 3'UTR//CDS//intron       24981863//22608085 chr11:82644238-82644239(+) m6A 3'UTR//CDS//intron       24981863//22608085 chr11:82644269-82644270(+) m6A 3'UTR//CDS//intron       24981863//22608085 chr11:82644288-82644289(+) m6A 3'UTR//CDS//intron       24981863//26404942//22608085 chr11:82644344-82644345(+) m6A 3'UTR//CDS//intron       24284625//24981863//26404942//27773535//22608085 chr11:82644442-82644443(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//22608085 chr11:82644495-82644496(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//22608085 chr11:82644556-82644557(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644618-82644619(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644679-82644680(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644726-82644727(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644745-82644746(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644761-82644762(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644827-82644828(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644864-82644865(+) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr11:82644954-82644955(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645091-82645092(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645097-82645098(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645106-82645107(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645113-82645114(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645179-82645180(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645228-82645229(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82645271-82645272(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82645341-82645342(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645389-82645390(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr11:82645402-82645403(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22608085 chr11:82645465-82645466(+) m6A 3'UTR//intron       24284625//25456834//24981863//26404942//22608085 chr11:82645490-82645491(+) m6A 3'UTR//intron       24284625//25456834//24981863//26404942//22608085 chr11:82645495-82645496(+) m6A 3'UTR//intron       24284625//25456834//24981863//26404942//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	DDIAS	Exosome Blood     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: DDIAS

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.