Basic Information:

  VIRBase ID:  

HHID00071164

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          ANO5:  NM_001142649     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	ANO5
miRBase Accession/Entrez ID	MIMAT0006764	203859
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GDD1//LGMD2L//LGMDR12//TMEM16E

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ANO5	chr11:22218317(+) A-I      intronic chr11:22218360(+) A-I      intronic chr11:22218365(+) A-I      intronic chr11:22217187(+) A-I      intronic chr11:22218300(+) A-I      intronic chr11:22217175(+) A-I      intronic chr11:22217159(+) A-I      intronic chr11:22218253(+) A-I      intronic chr11:22218239(+) A-I      intronic chr11:22218238(+) A-I      intronic chr11:22217049(+) A-I      intronic chr11:22290421(+) A-I      intronic chr11:22268158(+) A-I      intronic chr11:22216994(+) A-I      intronic chr11:22290507(+) A-I      intronic chr11:22218216(+) A-I      intronic chr11:22217092(+) A-I      intronic chr11:22290453(+) A-I      intronic chr11:22268281(+) A-I      intronic chr11:22217026(+) A-I      intronic chr11:22290505(+) A-I      intronic chr11:22268365(+) A-I      intronic chr11:22218268(+) A-I      intronic chr11:22216998(+) A-I      intronic chr11:22218359(+) A-I      intronic chr11:22268282(+) A-I      intronic chr11:22217252(+) A-I      intronic chr11:22217239(+) A-I      intronic chr11:22218318(+) A-I      intronic chr11:22229603(+) A-I      intronic chr11:22217075(+) A-I      intronic chr11:22226282(+) A-I      intronic chr11:22268331(+) A-I      intronic chr11:22217188(+) A-I      intronic chr11:22280629(+) A-I      intronic chr11:22217147(+) A-I      intronic chr11:22290380(+) A-I      intronic chr11:22228720(+) A-I      intronic chr11:22268334(+) A-I      intronic chr11:22247012(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ANO5	chr11:22228720(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ANO5	chr11:22214793-22214794(+) m6A 5'UTR       24209618//25456834//24981863//22608085 chr11:22301228-22301229(+) m6A CDS       24981863//22608085 chr11:22301279-22301280(+) m6A CDS       24981863//22608085 chr11:22301438-22301439(+) m6A 3'UTR       22608085 chr11:22301620-22301621(+) m6A 3'UTR       24209618//24981863//22608085 chr11:22301748-22301749(+) m6A 3'UTR       24981863//22608085 chr11:22301821-22301822(+) m6A 3'UTR       24981863//22608085 chr11:22301935-22301936(+) m6A 3'UTR       24981863//22608085 chr11:22301961-22301962(+) m6A 3'UTR       24981863//22608085 chr11:22302007-22302008(+) m6A 3'UTR       24981863//22608085 chr11:22302070-22302071(+) m6A 3'UTR       24981863//22608085 chr11:22304047-22304048(+) m6A 3'UTR       24981863 chr11:22304091-22304092(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	ANO5	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: ANO5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.