Basic Information:

  VIRBase ID:  

HHID00071163

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          PDE12:  NM_001322177     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	PDE12
miRBase Accession/Entrez ID	MIMAT0006764	201626
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	2'-PDE//2-PDE

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDE12	chr3:57544801(+) A-I      intronic chr3:57546192(+) A-I      3'UTR chr3:57546182(+) A-I      3'UTR chr3:57546153(+) A-I      3'UTR chr3:57546152(+) A-I      3'UTR chr3:57544357(+) A-I      intronic chr3:57544271(+) A-I      intronic chr3:57544889(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PDE12	chr3:57544357(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDE12	chr3:57542193-57542194(+) m6A CDS       24284625 chr3:57542243-57542244(+) m6A CDS       24284625 chr3:57542290-57542291(+) m6A CDS       24284625 chr3:57542603-57542604(+) m6A CDS       24284625//22575960 chr3:57542651-57542652(+) m6A CDS       24284625//22575960//22608085 chr3:57542781-57542782(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr3:57542787-57542788(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:57543019-57543020(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543033-57543034(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543103-57543104(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543119-57543120(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543344-57543345(+) m6A CDS       24284625//24981863//26404942//22608085 chr3:57543356-57543357(+) m6A CDS       24284625//24981863//26404942//22608085 chr3:57545061-57545062(+) m6A CDS       24284625//24981863//22608085 chr3:57545147-57545148(+) m6A 3'UTR//intron       24284625//22608085 chr3:57545207-57545208(+) m6A 3'UTR//intron       24284625//22608085 chr3:57545244-57545245(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr3:57545337-57545338(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr3:57545387-57545388(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr3:57545459-57545460(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22608085 chr3:57545538-57545539(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr3:57545619-57545620(+) m6A 3'UTR//CDS       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	PDE12	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: PDE12

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.