Detail Information

Basic Information:


  VIRBase ID:  

HHID00071158

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:           SIK1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-320d SIK1
miRBase
Accession/Entrez ID		 MIMAT0006764 150094
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DEE30//MSK//SIK//SIK-1//SIK1B//SNF1LK

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-320d
rs1013069487 chr13:40727828    T/C
rs1212045422 chr13:40727836    ACC/A
rs1287962814 chr13:40727836    A/G
rs755131134 chr13:40727846    T/C
rs757049836 chr13:40727829    C/A
rs757049836 chr13:40727829    C/T
rs772990558 chr13:40727831    T/C
rs1441164440 chrX:140926173    C/G
rs1556096982 chrX:140926178    C/G
rs782742486 chrX:140926174    C/G
rs782742486 chrX:140926174    C/T
rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T
rs535778068 chr13:40727842    C/G
rs569951817 chr13:40727839    C/T
rs1330731340 chrX:140926183    C/G
rs1384057774 chrX:140926185    G/A
rs1422735584 chrX:140926184    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SIK1
chr21:44834548-44834549(-) m6A 3'UTR       26404942
chr21:44834808-44834809(-) m6A 3'UTR       26404942
chr21:44834876-44834877(-) m6A 3'UTR       24284625//26404942//27773535
chr21:44834932-44834933(-) m6A 3'UTR       24284625//26404942//27773535
chr21:44834956-44834957(-) m6A 3'UTR       24284625//26404942//27773535//22575960
chr21:44834984-44834985(-) m6A 3'UTR       24284625//26404942//27773535//22575960
chr21:44835195-44835196(-) m6A 3'UTR       24284625//26404942
chr21:44835210-44835211(-) m6A 3'UTR       24284625//26404942
chr21:44835248-44835249(-) m6A 3'UTR       24284625
chr21:44835330-44835331(-) m6A 3'UTR       22575960
chr21:44835676-44835677(-) m6A 3'UTR       26404942
chr21:44835730-44835731(-) m6A 3'UTR       26404942
chr21:44835793-44835794(-) m6A 3'UTR       26404942//22575960
chr21:44835924-44835925(-) m6A 3'UTR       26404942//27371828//22575960
chr21:44835962-44835963(-) m6A 3'UTR       26404942//27371828//22575960
chr21:44835987-44835988(-) m6A 3'UTR       26404942//27371828
chr21:44836012-44836013(-) m6A 3'UTR       26404942
chr21:44836048-44836049(-) m6A 3'UTR       26404942
chr21:44836057-44836058(-) m6A 3'UTR       26404942
chr21:44836141-44836142(-) m6A 3'UTR       26404942
chr21:44836148-44836149(-) m6A 3'UTR       26404942
chr21:44836356-44836357(-) m6A 3'UTR       24284625//24209618//26404942//27773535
chr21:44836413-44836414(-) Am 3'UTR       -
chr21:44836425-44836426(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535
chr21:44836432-44836433(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535
chr21:44836535-44836536(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr21:44836557-44836558(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr21:44836596-44836597(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr21:44836664-44836665(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr21:44836679-44836680(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr21:44836787-44836788(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr21:44836827-44836828(-) m6A CDS       24284625//24209618//24981863//27371828//22575960
chr21:44837590-44837591(-) m6A CDS       24284625//25456834//24981863//26404942//27371828//27773536//22575960
chr21:44837595-44837596(-) m6A CDS       24284625//25456834//24981863//26404942//27371828//27773536//22575960
chr21:44837612-44837613(-) m6A CDS       24284625//24981863//26404942//27371828//27773536//22575960
chr21:44837621-44837622(-) m6A CDS       24284625//24981863//26404942//27371828//27773536//22575960
chr21:44838156-44838157(-) m6A CDS       24284625//24981863//27371828//27773536//22575960
chr21:44838376-44838377(-) m6A CDS       24284625
chr21:44838986-44838987(-) m6A CDS       24284625//26404942//22575960
chr21:44839040-44839041(-) m6A CDS       24284625//22575960
chr21:44839260-44839261(-) m6A CDS       24284625//22575960
chr21:44839294-44839295(-) m6A CDS       24284625//22575960
chr21:44839754-44839755(-) m6A CDS       24284625//22575960
chr21:44840132-44840133(-) m6A CDS       24284625//26404942
chr21:44840145-44840146(-) m6A CDS       24284625//26404942
chr21:44840227-44840228(-) m6A CDS       24284625
chr21:44840300-44840301(-) m6A CDS       24284625
chr21:44840938-44840939(-) m6A CDS       24284625//22575960
chr21:44841224-44841225(-) Cm CDS//exon       -
chr21:44845964-44845965(-) m6A CDS       22575960
chr21:44846029-44846030(-) m6A CDS       24284625//24209618//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-320d
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Plasma     23663360
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
SIK1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-320d
Eloxatine 5310940 Drug interaction    RC00007888
5-Fluorouracil 3385 Drug interaction    RC00007885
Doxorubicin 31703 Drug interaction    RC00007886
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884
Docetaxel 148124 Drug interaction    RC00007887
Marine fungal metabolite 1386A - Drug interaction    RC00007889
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-320d
Topotecan       60700
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-320d
Interactor2: SIK1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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