Basic Information:

  VIRBase ID:  

HHID00071153

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          MBD6:  NM_052897     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	MBD6
miRBase Accession/Entrez ID	MIMAT0006764	114785
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MBD6	chr12:57916781-57916782(+) m6A 5'UTR//intron       24284625 chr12:57917842-57917843(+) m6A 5'UTR//exon//intron       - chr12:57917847-57917848(+) m6A 5'UTR//exon//intron       - chr12:57917899-57917900(+) m6A 5'UTR//intron       - chr12:57919251-57919252(+) m6A CDS//intron       24981863 chr12:57919520-57919521(+) m6A CDS//intron       24284625//24209618//24981863 chr12:57919854-57919855(+) m6A CDS//intron       24284625 chr12:57919897-57919898(+) m6A CDS//intron       24284625 chr12:57920001-57920002(+) m6A CDS//intron       24284625 chr12:57920140-57920141(+) m6A CDS       - chr12:57921991-57921992(+) m6A CDS       24284625 chr12:57922114-57922115(+) m6A CDS       24284625//24981863 chr12:57922205-57922206(+) m6A CDS       - chr12:57922225-57922226(+) m6A CDS       - chr12:57922250-57922251(+) m6A CDS       - chr12:57922335-57922336(+) m6A CDS       - chr12:57922739-57922740(+) m6A CDS       24284625 chr12:57922760-57922761(+) m6A CDS       24284625 chr12:57922773-57922774(+) m6A CDS       24284625 chr12:57922991-57922992(+) m6A CDS       24284625 chr12:57923004-57923005(+) m6A CDS       24284625 chr12:57923105-57923106(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr12:57923264-57923265(+) Y 3'UTR//intron       26075521 chr12:57923413-57923414(+) m6A 3'UTR//intron       27773535 chr12:57923569-57923570(+) m6A 3'UTR//intron       - chr12:57923820-57923821(+) m6A 3'UTR       27773535 chr12:57923825-57923826(+) m6A 3'UTR       27773535 chr12:57923891-57923892(+) m6A 3'UTR       27773535 chr12:57923925-57923926(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	MBD6	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: MBD6

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.