Basic Information:

  VIRBase ID:  

HHID00071147

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          DNAJB14:  NM_001031723     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	DNAJB14
miRBase Accession/Entrez ID	MIMAT0006764	79982
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EGNR9427//PRO34683

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DNAJB14	chr4:100844952(-) A-I      ncRNA chr4:100837404(-) A-I      intronic chr4:100833878(-) A-I      intronic chr4:100833774(-) A-I      intronic chr4:100854573(-) A-I      intronic chr4:100854541(-) A-I      intronic chr4:100840574(-) A-I      intronic chr4:100840695(-) A-I      intronic chr4:100840658(-) A-I      intronic chr4:100860419(-) A-I      intronic chr4:100860450(-) A-I      intronic chr4:100861696(-) A-I      intronic chr4:100860462(-) A-I      intronic chr4:100840560(-) A-I      intronic chr4:100840516(-) A-I      intronic chr4:100838216(-) A-I      intronic chr4:100838210(-) A-I      intronic chr4:100838205(-) A-I      intronic chr4:100838180(-) A-I      intronic chr4:100861490(-) A-I      intronic chr4:100837507(-) A-I      intronic chr4:100860475(-) A-I      intronic chr4:100837484(-) A-I      intronic chr4:100860437(-) A-I      intronic chr4:100837471(-) A-I      intronic chr4:100837463(-) A-I      intronic chr4:100858352(-) A-I      intronic chr4:100860274(-) A-I      intronic chr4:100858417(-) A-I      intronic chr4:100858374(-) A-I      intronic chr4:100858349(-) A-I      intronic chr4:100858334(-) A-I      intronic chr4:100858303(-) A-I      intronic chr4:100858300(-) A-I      intronic chr4:100858275(-) A-I      intronic chr4:100857059(-) A-I      intronic chr4:100838168(-) A-I      intronic chr4:100865869(-) A-I      intronic chr4:100838118(-) A-I      intronic chr4:100837468(-) A-I      intronic chr4:100840507(-) A-I      intronic chr4:100837433(-) A-I      intronic chr4:100865820(-) A-I      intronic chr4:100833739(-) A-I      intronic chr4:100838209(-) A-I      intronic chr4:100861633(-) A-I      intronic chr4:100840620(-) A-I      intronic chr4:100833712(-) A-I      intronic chr4:100854659(-) A-I      intronic chr4:100836528(-) A-I      intronic chr4:100837503(-) A-I      intronic chr4:100858797(-) A-I      intronic chr4:100837464(-) A-I      intronic chr4:100837572(-) A-I      intronic chr4:100838127(-) A-I      intronic chr4:100838124(-) A-I      intronic chr4:100857103(-) A-I      intronic chr4:100833908(-) A-I      intronic chr4:100840655(-) A-I      intronic chr4:100838057(-) A-I      intronic chr4:100838192(-) A-I      intronic chr4:100838229(-) A-I      intronic chr4:100837447(-) A-I      intronic chr4:100854587(-) A-I      intronic chr4:100838047(-) A-I      intronic chr4:100837398(-) A-I      intronic chr4:100837334(-) A-I      intronic chr4:100833829(-) A-I      intronic chr4:100858306(-) A-I      intronic chr4:100833775(-) A-I      intronic chr4:100840654(-) A-I      intronic chr4:100854614(-) A-I      intronic chr4:100837466(-) A-I      intronic chr4:100838173(-) A-I      intronic chr4:100833713(-) A-I      intronic chr4:100861637(-) A-I      intronic chr4:100836566(-) A-I      intronic chr4:100857021(-) A-I      intronic chr4:100861765(-) A-I      intronic chr4:100837532(-) A-I      intronic chr4:100854727(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DNAJB14	chr4:100837398(-) A-I intron -    22327324 chr4:100837447(-) A-I intron -    22327324 chr4:100837503(-) A-I intron -    22327324 chr4:100837572(-) A-I intron -    21960545 chr4:100833712(-) A-G intron -    22484847 chr4:100833713(-) A-G intron -    22484847 chr4:100833739(-) A-G intron -    22484847 chr4:100833749(-) T-C intron -    22484847 chr4:100833829(-) A-G intron -    22484847 chr4:100833903(-) A-G intron -    22484847 chr4:100833908(-) A-G intron -    22484847 chr4:100837398(-) A-G intron -    22484847 chr4:100837424(-) A-G intron -    22484847 chr4:100837428(-) A-G intron -    22484847 chr4:100837433(-) A-G intron -    22484847 chr4:100837447(-) A-G intron -    22484847 chr4:100837464(-) A-G intron -    22484847 chr4:100837465(-) A-G intron -    22484847 chr4:100837503(-) A-G intron -    22484847 chr4:100837572(-) A-G intron -    22484847 chr4:100838048(-) A-G intron -    22484847 chr4:100838057(-) A-G intron -    22484847 chr4:100838118(-) A-G intron -    22484847 chr4:100838124(-) A-G intron -    22484847 chr4:100838127(-) A-G intron -    22484847 chr4:100838168(-) A-G intron -    22484847 chr4:100838170(-) A-G intron -    22484847 chr4:100838173(-) A-G intron -    22484847 chr4:100838209(-) A-G intron -    22484847 chr4:100838229(-) A-G intron -    22484847 chr4:100838245(-) A-G intron -    22484847 chr4:100840507(-) A-G intron -    22484847 chr4:100854659(-) A-G intron -    22484847 chr4:100857021(-) A-G intron -    22484847 chr4:100858284(-) A-G intron -    22484847 chr4:100858306(-) A-G intron -    22484847 chr4:100858445(-) G-A intron -    22484847 chr4:100861633(-) A-G intron -    22484847 chr4:100865869(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DNAJB14	chr4:100822009-100822010(-) m6A 3'UTR//exon       27773535//22608085 chr4:100822050-100822051(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr4:100822078-100822079(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr4:100822083-100822084(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr4:100822183-100822184(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr4:100822233-100822234(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr4:100822306-100822307(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22608085 chr4:100824889-100824890(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22608085 chr4:100824989-100824990(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:100825019-100825020(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:100825026-100825027(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:100825041-100825042(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:100825050-100825051(-) m6A 3'UTR//CDS//exon       24981863//27773535 chr4:100827700-100827701(-) m6A 3'UTR//CDS//exon       27773535 chr4:100829905-100829906(-) m6A 3'UTR//CDS//exon       27773535 chr4:100829959-100829960(-) m6A 3'UTR//CDS//exon       27773535 chr4:100829979-100829980(-) m6A 3'UTR//CDS//exon       27773535 chr4:100830006-100830007(-) m6A 3'UTR//CDS//exon       27773535 chr4:100851716-100851717(-) m6A CDS//exon//intron       27371828 chr4:100867717-100867718(-) m6A CDS//exon       25456834//24981863//27371828//27773536 chr4:100867739-100867740(-) m1A 5'UTR//exon       26863196//26863410

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	DNAJB14	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: DNAJB14

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.