Detail Information

Basic Information:


  VIRBase ID:  

HHID00071135

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:           TMEM106B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-320d TMEM106B
miRBase
Accession/Entrez ID		 MIMAT0006764 54664
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HLD16

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-320d
rs1013069487 chr13:40727828    T/C
rs1212045422 chr13:40727836    ACC/A
rs1287962814 chr13:40727836    A/G
rs755131134 chr13:40727846    T/C
rs757049836 chr13:40727829    C/A
rs757049836 chr13:40727829    C/T
rs772990558 chr13:40727831    T/C
rs1441164440 chrX:140926173    C/G
rs1556096982 chrX:140926178    C/G
rs782742486 chrX:140926174    C/G
rs782742486 chrX:140926174    C/T
rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T
rs535778068 chr13:40727842    C/G
rs569951817 chr13:40727839    C/T
rs1330731340 chrX:140926183    C/G
rs1384057774 chrX:140926185    G/A
rs1422735584 chrX:140926184    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMEM106B
chr7:12263476(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM106B
chr7:12250974-12250975(+) m6A 5'UTR//exon       24981863
chr7:12250981-12250982(+) m6A 5'UTR//exon       24981863
chr7:12251028-12251029(+) m6A 5'UTR//exon       24981863
chr7:12254509-12254510(+) m6A CDS//exon       26404942
chr7:12254522-12254523(+) m6A CDS//exon       26404942
chr7:12271498-12271499(+) m6A CDS//exon       24981863//22608085
chr7:12271542-12271543(+) m6A CDS//exon       24981863//26404942//22608085
chr7:12271603-12271604(+) m6A 3'UTR//exon       24981863//26404942//22608085
chr7:12271683-12271684(+) m6A 3'UTR//exon       24981863//26404942//22608085
chr7:12271695-12271696(+) m6A 3'UTR//exon       24981863//26404942//22608085
chr7:12271742-12271743(+) m6A 3'UTR//exon       26404942//22608085
chr7:12272660-12272661(+) Y 3'UTR       26075521
chr7:12273990-12273991(+) m6A 3'UTR       24981863
chr7:12274003-12274004(+) m6A 3'UTR       24981863
chr7:12274086-12274087(+) m6A 3'UTR       24981863
chr7:12274091-12274092(+) m6A 3'UTR       24981863
chr7:12274111-12274112(+) m6A 3'UTR       24981863
chr7:12274118-12274119(+) m6A 3'UTR       24981863
chr7:12274154-12274155(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-320d
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Plasma     23663360
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
TMEM106B
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-320d
Eloxatine 5310940 Drug interaction    RC00007888
5-Fluorouracil 3385 Drug interaction    RC00007885
Doxorubicin 31703 Drug interaction    RC00007886
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884
Docetaxel 148124 Drug interaction    RC00007887
Marine fungal metabolite 1386A - Drug interaction    RC00007889
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-320d
Topotecan       60700
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-320d
Interactor2: TMEM106B

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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