Basic Information:

  VIRBase ID:  

HHID00071131

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          CD274:  NR_052005     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	CD274
miRBase Accession/Entrez ID	MIMAT0006764	29126
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	B7-H//B7H1//hPD-L1//PD-L1//PDCD1L1//PDCD1LG1//PDL1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CD274	chr9:5457102-5457103(+) m6A CDS//exon//intron       24981863 chr9:5457163-5457164(+) m6A CDS//exon//intron       24981863 chr9:5457171-5457172(+) m6A CDS//exon//intron       24981863 chr9:5457213-5457214(+) m6A CDS//exon//intron       24981863 chr9:5457243-5457244(+) m6A CDS//exon//intron       24981863 chr9:5457271-5457272(+) m6A CDS//exon//intron       24981863 chr9:5457294-5457295(+) m6A CDS//exon//intron       24981863 chr9:5462940-5462941(+) m6A CDS//exon       24981863 chr9:5462973-5462974(+) m6A CDS//exon//intron       24981863 chr9:5466811-5466812(+) m6A CDS//exon       24981863 chr9:5467874-5467875(+) m6A 3'UTR       24981863 chr9:5467979-5467980(+) m6A 3'UTR       24981863 chr9:5468008-5468009(+) m6A 3'UTR       24981863 chr9:5468052-5468053(+) m6A 3'UTR       24981863 chr9:5468071-5468072(+) m6A 3'UTR       24981863 chr9:5468138-5468139(+) m6A 3'UTR       24981863 chr9:5468294-5468295(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	CD274	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: CD274

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.