Basic Information:

  VIRBase ID:  

HHID00071130

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          ARFIP1:  NM_001025595     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	ARFIP1
miRBase Accession/Entrez ID	MIMAT0006764	27236
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSU52521

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARFIP1	chr4:153816903(+) A-I      intronic chr4:153710302(+) A-I      intronic chr4:153826914(+) A-I      intronic chr4:153711979(+) A-I      intronic chr4:153826926(+) A-I      intronic chr4:153826939(+) A-I      intronic chr4:153830438(+) A-I      intronic chr4:153830524(+) A-I      intronic chr4:153779248(+) A-I      intronic chr4:153710274(+) A-I      intronic chr4:153710266(+) A-I      intronic chr4:153735718(+) A-I      intronic chr4:153704406(+) A-I      intronic chr4:153709673(+) A-I      intronic chr4:153710262(+) A-I      intronic chr4:153709742(+) A-I      intronic chr4:153728015(+) A-I      intronic chr4:153728009(+) A-I      intronic chr4:153728030(+) A-I      intronic chr4:153730124(+) A-I      intronic chr4:153710504(+) A-I      intronic chr4:153710342(+) A-I      intronic chr4:153730161(+) A-I      intronic chr4:153731821(+) A-I      intronic chr4:153731853(+) A-I      intronic chr4:153733464(+) A-I      intronic chr4:153735448(+) A-I      intronic chr4:153735606(+) A-I      intronic chr4:153735711(+) A-I      intronic chr4:153745367(+) A-I      intronic chr4:153780434(+) A-I      intronic chr4:153780448(+) A-I      intronic chr4:153815368(+) A-I      intronic chr4:153816799(+) A-I      intronic chr4:153816806(+) A-I      intronic chr4:153816852(+) A-I      intronic chr4:153816854(+) A-I      intronic chr4:153702481(+) A-I      intronic chr4:153735480(+) A-I      intronic chr4:153704339(+) A-I      intronic chr4:153779224(+) A-I      intronic chr4:153780428(+) A-I      intronic chr4:153735408(+) A-I      intronic chr4:153735607(+) A-I      intronic chr4:153731847(+) A-I      intronic chr4:153780449(+) A-I      intronic chr4:153710343(+) A-I      intronic chr4:153709670(+) A-I      intronic chr4:153825528(+) A-I      intronic chr4:153813294(+) A-I      intronic chr4:153735775(+) A-I      intronic chr4:153812999(+) A-I      intronic chr4:153735701(+) A-I      intronic chr4:153728042(+) A-I      intronic chr4:153733480(+) A-I      intronic chr4:153710423(+) A-I      intronic chr4:153779285(+) A-I      intronic chr4:153780293(+) A-I      intronic chr4:153709753(+) A-I      intronic chr4:153702569(+) A-I      intronic chr4:153733476(+) A-I      intronic chr4:153730191(+) A-I      intronic chr4:153780313(+) A-I      intronic chr4:153709294(+) A-I      intronic chr4:153733486(+) A-I      intronic chr4:153702572(+) A-I      intronic chr4:153780435(+) A-I      intronic chr4:153735297(+) A-I      intronic chr4:153735508(+) A-I      intronic chr4:153709667(+) A-I      intronic chr4:153830273(+) A-I      intronic chr4:153735311(+) A-I      intronic chr4:153779243(+) A-I      intronic chr4:153709274(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARFIP1	chr4:153726958(+) A-G intron -    22484847 chr4:153754647(+) A-G intron -    22484847 chr4:153754743(+) A-G intron -    22484847 chr4:153767305(+) T-C intron -    22484847 chr4:153702379(+) C-T intron -    22484847 chr4:153702481(+) A-G intron -    22484847 chr4:153702569(+) A-G intron -    22484847 chr4:153702572(+) A-G intron -    22484847 chr4:153709622(+) A-G intron -    22484847 chr4:153709667(+) A-G intron -    22484847 chr4:153709670(+) A-G intron -    22484847 chr4:153709671(+) A-G intron -    22484847 chr4:153709674(+) A-G intron -    22484847 chr4:153709753(+) A-G intron -    22484847 chr4:153710343(+) A-G intron -    22484847 chr4:153710423(+) A-G intron -    22484847 chr4:153731847(+) A-G intron -    22484847 chr4:153733476(+) A-G intron -    22484847 chr4:153733480(+) A-G intron -    22484847 chr4:153733486(+) A-G intron -    22484847 chr4:153735254(+) T-C intron -    22484847 chr4:153735404(+) A-G intron -    22484847 chr4:153735408(+) A-G intron -    22484847 chr4:153735480(+) A-G intron -    22484847 chr4:153735508(+) A-G intron -    22484847 chr4:153735607(+) A-G intron -    22484847 chr4:153735648(+) A-G intron -    22484847 chr4:153735701(+) A-G intron -    22484847 chr4:153735712(+) A-G intron -    22484847 chr4:153735775(+) A-G intron -    22484847 chr4:153779224(+) A-G intron -    22484847 chr4:153780428(+) A-G intron -    22484847 chr4:153780449(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARFIP1	chr4:153701263-153701264(+) m1A 5'UTR//exon//intron       26863196 chr4:153809320-153809321(+) m6A CDS//exon       24981863 chr4:153809332-153809333(+) m6A CDS//exon       24981863 chr4:153809346-153809347(+) m6A CDS//exon       24981863 chr4:153831295-153831296(+) m6A CDS//exon       24981863//27773535//22608085 chr4:153831307-153831308(+) m6A CDS//exon       24981863//27773535//22608085 chr4:153831329-153831330(+) m6A CDS//exon       24981863//27773535//22608085 chr4:153831364-153831365(+) m6A CDS//exon       24981863//27773535//22608085 chr4:153831417-153831418(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr4:153831491-153831492(+) m6A 3'UTR//exon       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	ARFIP1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: ARFIP1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.