Basic Information:

  VIRBase ID:  

HHID00071129

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          THUMPD3:  NM_015453     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	THUMPD3
miRBase Accession/Entrez ID	MIMAT0006764	25917
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	THUMPD3	chr3:9409965(+) A-I      intronic chr3:9412208(+) A-I      intronic chr3:9412222(+) A-I      intronic chr3:9412232(+) A-I      intronic chr3:9412241(+) A-I      intronic chr3:9414219(+) A-I      intronic chr3:9414170(+) A-I      intronic chr3:9413701(+) A-I      intronic chr3:9426638(+) A-I      3'UTR chr3:9426588(+) A-I      3'UTR chr3:9426592(+) A-I      3'UTR chr3:9426598(+) A-I      3'UTR chr3:9414179(+) A-I      intronic chr3:9413640(+) A-I      intronic chr3:9413630(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	THUMPD3	chr3:9404916-9404917(+) m6A 5'UTR//intron       27773536 chr3:9405245-9405246(+) m6A 5'UTR//intron       24981863 chr3:9406795-9406796(+) m6A CDS       27773535 chr3:9406807-9406808(+) m6A CDS       27773535 chr3:9408659-9408660(+) m6A CDS       27773535 chr3:9412768-9412769(+) m6A CDS       24981863//27773535//22608085 chr3:9412781-9412782(+) m6A CDS       24981863//27773535//22608085 chr3:9412795-9412796(+) m6A CDS       24981863//27773535//22608085 chr3:9412895-9412896(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr3:9413046-9413047(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:9413070-9413071(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:9413123-9413124(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:9416209-9416210(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr3:9426329-9426330(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:9426348-9426349(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:9426425-9426426(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:9426453-9426454(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:9426474-9426475(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:9426548-9426549(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr3:9426959-9426960(+) m6A 3'UTR       27773535 chr3:9427303-9427304(+) m6A 3'UTR       27773535 chr3:9427346-9427347(+) m6A 3'UTR       27773535 chr3:9427354-9427355(+) m6A 3'UTR       27773535 chr3:9427409-9427410(+) m6A 3'UTR       27773535 chr3:9427414-9427415(+) m6A 3'UTR       27773535 chr3:9427420-9427421(+) m6A 3'UTR       27773535 chr3:9427490-9427491(+) m6A 3'UTR       24981863//27773535 chr3:9427612-9427613(+) m6A 3'UTR       24981863//27773535 chr3:9427641-9427642(+) m6A 3'UTR       27773535 chr3:9427976-9427977(+) m6A 3'UTR       - chr3:9427985-9427986(+) m6A 3'UTR       - chr3:9428009-9428010(+) m6A 3'UTR       - chr3:9428025-9428026(+) m6A 3'UTR       - chr3:9428423-9428424(+) m6A 3'UTR       27773535 chr3:9428467-9428468(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	THUMPD3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: THUMPD3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.