Basic Information:

  VIRBase ID:  

HHID00071121

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          SLC35A1:  NM_006416     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	SLC35A1
miRBase Accession/Entrez ID	MIMAT0006764	10559
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDG2F//CMPST//CST//hCST

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC35A1	chr6:88206345(+) A-I      intronic chr6:88206346(+) A-I      intronic chr6:88206347(+) A-I      intronic chr6:88206348(+) A-I      intronic chr6:88206355(+) A-I      intronic chr6:88206387(+) A-I      intronic chr6:88206455(+) A-I      intronic chr6:88206458(+) A-I      intronic chr6:88206463(+) A-I      intronic chr6:88206493(+) A-I      intronic chr6:88206326(+) A-I      intronic chr6:88206338(+) A-I      intronic chr6:88206341(+) A-I      intronic chr6:88200217(+) A-I      intronic chr6:88200218(+) A-I      intronic chr6:88205429(+) A-I      intronic chr6:88205503(+) A-I      intronic chr6:88205513(+) A-I      intronic chr6:88205515(+) A-I      intronic chr6:88205539(+) A-I      intronic chr6:88208272(+) A-I      intronic chr6:88208312(+) A-I      intronic chr6:88208374(+) A-I      intronic chr6:88195249(+) A-I      intronic chr6:88199841(+) A-I      intronic chr6:88199784(+) A-I      intronic chr6:88199797(+) A-I      intronic chr6:88199875(+) A-I      intronic chr6:88199832(+) A-I      intronic chr6:88199763(+) A-I      intronic chr6:88199353(+) A-I      intronic chr6:88195360(+) A-I      intronic chr6:88195383(+) A-I      intronic chr6:88218640(+) A-I      3'UTR chr6:88206453(+) A-I      intronic chr6:88204849(+) A-I      intronic chr6:88208263(+) A-I      intronic chr6:88199432(+) A-I      intronic chr6:88220416(+) A-I      intronic chr6:88205540(+) A-I      intronic chr6:88208337(+) A-I      intronic chr6:88206400(+) A-I      intronic chr6:88207564(+) A-I      intronic chr6:88207473(+) A-I      intronic chr6:88208395(+) A-I      intronic chr6:88200182(+) A-I      intronic chr6:88208440(+) A-I      intronic chr6:88207682(+) A-I      intronic chr6:88210611(+) A-I      intronic chr6:88208408(+) A-I      intronic chr6:88199443(+) A-I      intronic chr6:88207576(+) A-I      intronic chr6:88200152(+) A-I      intronic chr6:88204829(+) A-I      intronic chr6:88207559(+) A-I      intronic chr6:88204280(+) A-I      intronic chr6:88208378(+) A-I      intronic chr6:88204827(+) A-I      intronic chr6:88199796(+) A-I      intronic chr6:88202542(+) A-I      intronic chr6:88208276(+) A-I      intronic chr6:88208433(+) A-I      intronic chr6:88207533(+) A-I      intronic chr6:88207699(+) A-I      intronic chr6:88195321(+) A-I      intronic chr6:88199930(+) A-I      intronic chr6:88207708(+) A-I      intronic chr6:88204898(+) A-I      intronic chr6:88208352(+) A-I      intronic chr6:88199782(+) A-I      intronic chr6:88206243(+) A-I      intronic chr6:88207681(+) A-I      intronic chr6:88204817(+) A-I      intronic chr6:88204916(+) A-I      intronic chr6:88202530(+) A-I      intronic chr6:88206377(+) A-I      intronic chr6:88206351(+) A-I      intronic chr6:88213862(+) A-I      intronic chr6:88204746(+) A-I      intronic chr6:88206448(+) A-I      intronic chr6:88195205(+) A-I      intronic chr6:88199497(+) A-I      intronic chr6:88207686(+) A-I      intronic chr6:88199745(+) A-I      intronic chr6:88199768(+) A-I      intronic chr6:88202434(+) A-I      intronic chr6:88209662(+) A-I      intronic chr6:88199867(+) A-I      intronic chr6:88207478(+) A-I      intronic chr6:88190977(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC35A1	chr6:88207692(+) A-I intron -    22327324 chr6:88199754(+) T-C intron -    22484847 chr6:88199769(+) A-G intron -    22484847 chr6:88199782(+) A-G intron -    22484847 chr6:88199836(+) A-G intron -    22484847 chr6:88199871(+) T-C intron -    22484847 chr6:88199911(+) T-C intron -    22484847 chr6:88199928(+) T-C intron -    22484847 chr6:88200182(+) A-G intron -    22484847 chr6:88204746(+) A-G intron -    22484847 chr6:88205540(+) A-G intron -    22484847 chr6:88205625(+) A-G intron -    22484847 chr6:88206243(+) A-G intron -    22484847 chr6:88206400(+) A-G intron -    22484847 chr6:88206401(+) A-G intron -    22484847 chr6:88206404(+) A-G intron -    22484847 chr6:88206415(+) T-C intron -    22484847 chr6:88206467(+) T-C intron -    22484847 chr6:88207473(+) A-G intron -    22484847 chr6:88207478(+) A-G intron -    22484847 chr6:88207692(+) T-C intron -    22484847 chr6:88207697(+) T-C intron -    22484847 chr6:88208276(+) A-G intron -    22484847 chr6:88208330(+) A-G intron -    22484847 chr6:88208352(+) A-G intron -    22484847 chr6:88208378(+) A-G intron -    22484847 chr6:88208395(+) A-G intron -    22484847 chr6:88209700(+) A-G intron -    22484847 chr6:88210747(+) T-C intron -    22484847 chr6:88220344(+) T-C intron -    22484847 chr6:88220366(+) T-C intron -    22484847 chr6:88220503(+) T-C intron -    22484847 chr6:88220521(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC35A1	chr6:88182718-88182719(+) m6A 5'UTR//intron       24981863 chr6:88218802-88218803(+) Y CDS//exon       26075521 chr6:88221180-88221181(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr6:88221185-88221186(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr6:88221211-88221212(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr6:88221261-88221262(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:88221273-88221274(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:88221278-88221279(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:88221292-88221293(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr6:88221328-88221329(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr6:88221375-88221376(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr6:88221385-88221386(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr6:88221407-88221408(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr6:88221422-88221423(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr6:88221433-88221434(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	SLC35A1	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: SLC35A1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.