Basic Information:

  VIRBase ID:  

HHID00071108

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          TRIM24:  NM_015905     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	TRIM24
miRBase Accession/Entrez ID	MIMAT0006764	8805
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	hTIF1//PTC6//RNF82//TF1A//TIF1//TIF1A//TIF1ALPHA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRIM24	chr7:138200781(+) A-I      intronic chr7:138201335(+) A-I      intronic chr7:138179279(+) A-I      intronic chr7:138179053(+) A-I      intronic chr7:138179300(+) A-I      intronic chr7:138166428(+) A-I      intronic chr7:138166425(+) A-I      intronic chr7:138165817(+) A-I      intronic chr7:138165831(+) A-I      intronic chr7:138251186(+) A-I      intronic chr7:138251075(+) A-I      intronic chr7:138251111(+) A-I      intronic chr7:138251146(+) A-I      intronic chr7:138251141(+) A-I      intronic chr7:138251118(+) A-I      intronic chr7:138251114(+) A-I      intronic chr7:138251006(+) A-I      intronic chr7:138251005(+) A-I      intronic chr7:138250983(+) A-I      intronic chr7:138240357(+) A-I      intronic chr7:138240297(+) A-I      intronic chr7:138202241(+) A-I      intronic chr7:138202228(+) A-I      intronic chr7:138166299(+) A-I      intronic chr7:138165867(+) A-I      intronic chr7:138194374(+) A-I      intronic chr7:138202185(+) A-I      intronic chr7:138202166(+) A-I      intronic chr7:138251167(+) A-I      intronic chr7:138154157(+) A-I      intronic chr7:138154155(+) A-I      intronic chr7:138240328(+) A-I      intronic chr7:138201283(+) A-I      intronic chr7:138154154(+) A-I      intronic chr7:138194355(+) A-I      intronic chr7:138186123(+) A-I      intronic chr7:138186115(+) A-I      intronic chr7:138186105(+) A-I      intronic chr7:138186079(+) A-I      intronic chr7:138190351(+) A-I      intronic chr7:138154158(+) A-I      intronic chr7:138154195(+) A-I      intronic chr7:138194328(+) A-I      intronic chr7:138194302(+) A-I      intronic chr7:138194291(+) A-I      intronic chr7:138194289(+) A-I      intronic chr7:138156366(+) A-I      intronic chr7:138194310(+) A-I      intronic chr7:138156538(+) A-I      intronic chr7:138157879(+) A-I      intronic chr7:138157936(+) A-I      intronic chr7:138160441(+) A-I      intronic chr7:138161177(+) A-I      intronic chr7:138162049(+) A-I      intronic chr7:138194285(+) A-I      intronic chr7:138194282(+) A-I      intronic chr7:138193937(+) A-I      intronic chr7:138193717(+) A-I      intronic chr7:138192563(+) A-I      intronic chr7:138185372(+) A-I      intronic chr7:138194271(+) A-I      intronic chr7:138256521(+) A-I      intronic chr7:138194404(+) A-I      intronic chr7:138193875(+) A-I      intronic chr7:138165768(+) A-I      intronic chr7:138194397(+) A-I      intronic chr7:138179126(+) A-I      intronic chr7:138161173(+) A-I      intronic chr7:138200892(+) A-I      intronic chr7:138166013(+) A-I      intronic chr7:138240305(+) A-I      intronic chr7:138166466(+) A-I      intronic chr7:138201239(+) A-I      intronic chr7:138196200(+) A-I      intronic chr7:138194237(+) A-I      intronic chr7:138201784(+) A-I      intronic chr7:138161178(+) A-I      intronic chr7:138193946(+) A-I      intronic chr7:138193894(+) A-I      intronic chr7:138161923(+) A-I      intronic chr7:138201289(+) A-I      intronic chr7:138201300(+) A-I      intronic chr7:138200900(+) A-I      intronic chr7:138193794(+) A-I      intronic chr7:138195267(+) A-I      intronic chr7:138192557(+) A-I      intronic chr7:138201172(+) A-I      intronic chr7:138179132(+) A-I      intronic chr7:138160413(+) A-I      intronic chr7:138183564(+) A-I      intronic chr7:138160417(+) A-I      intronic chr7:138185420(+) A-I      intronic chr7:138273280(+) A-I      3'UTR chr7:138271978(+) A-I      3'UTR chr7:138196199(+) A-I      intronic chr7:138200842(+) A-I      intronic chr7:138201765(+) A-I      intronic chr7:138251011(+) A-I      intronic chr7:138166366(+) A-I      intronic chr7:138189347(+) A-I      intronic chr7:138179125(+) A-I      intronic chr7:138148260(+) A-I      intronic chr7:138192200(+) A-I      intronic chr7:138192265(+) A-I      intronic chr7:138160385(+) A-I      intronic chr7:138192162(+) A-I      intronic chr7:138201713(+) A-I      intronic chr7:138194329(+) A-I      intronic chr7:138186485(+) A-I      intronic chr7:138200790(+) A-I      intronic chr7:138201653(+) A-I      intronic chr7:138160360(+) A-I      intronic chr7:138202268(+) A-I      intronic chr7:138201814(+) A-I      intronic chr7:138192213(+) A-I      intronic chr7:138195270(+) A-I      intronic chr7:138240327(+) A-I      intronic chr7:138178783(+) A-I      intronic chr7:138160439(+) A-I      intronic chr7:138240426(+) A-I      intronic chr7:138202381(+) A-I      intronic chr7:138192567(+) A-I      intronic chr7:138158655(+) A-I      intronic chr7:138193860(+) A-I      intronic chr7:138166338(+) A-I      intronic chr7:138202245(+) A-I      intronic chr7:138201727(+) A-I      intronic chr7:138194194(+) A-I      intronic chr7:138193851(+) A-I      intronic chr7:138240501(+) A-I      intronic chr7:138194193(+) A-I      intronic chr7:138186141(+) A-I      intronic chr7:138163280(+) A-I      intronic chr7:138201377(+) A-I      intronic chr7:138186522(+) A-I      intronic chr7:138240361(+) A-I      intronic chr7:138163270(+) A-I      intronic chr7:138201229(+) A-I      intronic chr7:138194338(+) A-I      intronic chr7:138267398(+) A-I      intronic chr7:138251176(+) A-I      intronic chr7:138240434(+) A-I      intronic chr7:138202216(+) A-I      intronic chr7:138193749(+) A-I      intronic chr7:138202393(+) A-I      intronic chr7:138161937(+) A-I      intronic chr7:138194286(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TRIM24	chr7:138194329(+) A-I intron -    22327324 chr7:138147104(+) G-T intron -    22484847 chr7:138152367(+) G-A intron -    22484847 chr7:138154094(+) G-T intron -    22484847 chr7:138154975(+) A-G intron -    22484847 chr7:138154982(+) C-T intron -    22484847 chr7:138158628(+) A-G intron -    22484847 chr7:138158655(+) A-G intron -    22484847 chr7:138160355(+) A-G intron -    22484847 chr7:138160360(+) A-G intron -    22484847 chr7:138160373(+) A-G intron -    22484847 chr7:138160381(+) A-G intron -    22484847 chr7:138160413(+) A-G intron -    22484847 chr7:138160417(+) A-G intron -    22484847 chr7:138161173(+) A-G intron -    22484847 chr7:138161178(+) A-G intron -    22484847 chr7:138161923(+) A-G intron -    22484847 chr7:138161937(+) A-G intron -    22484847 chr7:138161986(+) A-G intron -    22484847 chr7:138166292(+) A-G intron -    22484847 chr7:138166338(+) A-G intron -    22484847 chr7:138166366(+) A-G intron -    22484847 chr7:138166457(+) A-G intron -    22484847 chr7:138178783(+) A-G intron -    22484847 chr7:138179125(+) A-G intron -    22484847 chr7:138179126(+) A-G intron -    22484847 chr7:138179132(+) A-G intron -    22484847 chr7:138186522(+) A-G intron -    22484847 chr7:138189347(+) A-G intron -    22484847 chr7:138192162(+) A-G intron -    22484847 chr7:138192557(+) A-G intron -    22484847 chr7:138193833(+) A-G intron -    22484847 chr7:138193851(+) A-G intron -    22484847 chr7:138193860(+) A-G intron -    22484847 chr7:138194193(+) A-G intron -    22484847 chr7:138194329(+) A-G intron -    22484847 chr7:138194338(+) A-G intron -    22484847 chr7:138200857(+) A-G intron -    22484847 chr7:138200900(+) A-G intron -    22484847 chr7:138201126(+) A-G intron -    22484847 chr7:138201172(+) A-G intron -    22484847 chr7:138201180(+) A-G intron -    22484847 chr7:138201229(+) A-G intron -    22484847 chr7:138201230(+) A-G intron -    22484847 chr7:138201289(+) A-G intron -    22484847 chr7:138201300(+) A-G intron -    22484847 chr7:138202216(+) A-G intron -    22484847 chr7:138207081(+) C-A intron -    22484847 chr7:138240305(+) A-G intron -    22484847 chr7:138240327(+) A-G intron -    22484847 chr7:138240361(+) A-G intron -    22484847 chr7:138240426(+) A-G intron -    22484847 chr7:138240434(+) A-G intron -    22484847 chr7:138251011(+) A-G intron -    22484847 chr7:138267014(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRIM24	chr7:138145253-138145254(+) m6A 5'UTR       24209618//25456834//24981863//22608085 chr7:138145290-138145291(+) m6A 5'UTR       24209618//25456834//24981863//22608085 chr7:138145411-138145412(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr7:138145453-138145454(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr7:138145477-138145478(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr7:138145593-138145594(+) m6A CDS       25456834 chr7:138204010-138204011(+) m6A CDS//exon       27773535 chr7:138204021-138204022(+) m6A CDS//exon       27773535 chr7:138204035-138204036(+) m6A CDS//exon       24981863//27773535 chr7:138204051-138204052(+) m6A CDS//exon       24981863//27773535 chr7:138210048-138210049(+) m6A CDS//exon       24981863//27773535 chr7:138210061-138210062(+) m6A CDS//exon       24981863//27773535 chr7:138210098-138210099(+) m6A CDS//exon       24981863//27773535//22608085 chr7:138213896-138213897(+) m6A CDS//exon       24981863//27773535//22608085 chr7:138239506-138239507(+) m6A CDS//exon       27773535 chr7:138239541-138239542(+) m6A CDS//exon       27773535 chr7:138239664-138239665(+) m6A CDS//exon//intron       24981863//27773535 chr7:138241100-138241101(+) m6A exon//intron       24284625//24981863 chr7:138252247-138252248(+) m6A CDS//exon       24284625//24981863//27773535 chr7:138252269-138252270(+) m6A CDS//exon       24284625//24981863//27773535 chr7:138252278-138252279(+) m6A CDS//exon       24284625//24981863//27773535 chr7:138252322-138252323(+) m6A CDS//exon       24284625//24981863//27773535 chr7:138252328-138252329(+) m6A CDS//exon       24284625//24981863//27773535 chr7:138252355-138252356(+) m6A CDS//exon       24284625//24981863//27773535 chr7:138252395-138252396(+) m6A CDS//exon       24981863//27773535 chr7:138255591-138255592(+) m6A CDS//exon       24981863//27773535 chr7:138255598-138255599(+) m6A CDS//exon       24981863//27773535 chr7:138258279-138258280(+) m6A CDS//exon       - chr7:138258325-138258326(+) m6A CDS//exon       - chr7:138258336-138258337(+) m6A CDS//exon       - chr7:138264064-138264065(+) m6A CDS       27773535 chr7:138264075-138264076(+) m6A CDS       27773535 chr7:138264143-138264144(+) m6A CDS       27773535 chr7:138269518-138269519(+) m6A CDS       27773535//22608085 chr7:138269539-138269540(+) m6A CDS       24981863//27773535//22608085 chr7:138269550-138269551(+) m6A CDS       24981863//27773535//22608085 chr7:138269578-138269579(+) m6A CDS       24981863//27773535//22608085 chr7:138269749-138269750(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:138269827-138269828(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr7:138269968-138269969(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr7:138269974-138269975(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr7:138270002-138270003(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr7:138270042-138270043(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr7:138270053-138270054(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr7:138270182-138270183(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:138270196-138270197(+) m6A 3'UTR       24981863//27773535//22608085 chr7:138270328-138270329(+) m6A 3'UTR       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	TRIM24	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: TRIM24

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.