Basic Information:

  VIRBase ID:  

HHID00071094

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          NAB1:  NM_001321315     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	NAB1
miRBase Accession/Entrez ID	MIMAT0006764	4664
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NAB1	chr2:191529349(+) A-I      intronic chr2:191529378(+) A-I      intronic chr2:191553751(+) A-I      intronic chr2:191531347(+) A-I      intronic chr2:191529410(+) A-I      intronic chr2:191529144(+) A-I      intronic chr2:191531177(+) A-I      intronic chr2:191529928(+) A-I      intronic chr2:191529121(+) A-I      intronic chr2:191531428(+) A-I      intronic chr2:191529139(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NAB1	chr2:191537937(+) A-G intron -    21725310 chr2:191529094(+) A-G intron -    22484847 chr2:191529109(+) A-G intron -    22484847 chr2:191529139(+) A-G intron -    22484847 chr2:191529144(+) A-G intron -    22484847 chr2:191529928(+) A-G intron -    22484847 chr2:191531313(+) T-C intron -    22484847 chr2:191531326(+) T-C intron -    22484847 chr2:191531327(+) T-C intron -    22484847 chr2:191531405(+) T-C intron -    22484847 chr2:191538178(+) T-C intron -    22484847 chr2:191538179(+) T-C intron -    22484847 chr2:191556847(+) G-T intron -    22484847 chr2:191556849(+) A-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NAB1	chr2:191513895-191513896(+) m1A 5'UTR//intron       26863196//26863410 chr2:191514065-191514066(+) m6A 5'UTR//intron       24209618 chr2:191514607-191514608(+) m6A 5'UTR//intron       24209618 chr2:191514637-191514638(+) m6A 5'UTR//intron       24209618 chr2:191514674-191514675(+) m6A 5'UTR//intron       24209618 chr2:191514685-191514686(+) m6A 5'UTR//intron       24209618 chr2:191518454-191518455(+) m6A 5'UTR//intron       24209618 chr2:191518469-191518470(+) m6A 5'UTR//intron       24209618 chr2:191518489-191518490(+) m6A 5'UTR//intron       24209618 chr2:191520720-191520721(+) m6A 5'UTR//intron       24209618 chr2:191523888-191523889(+) m6A 5'UTR//intron       24981863 chr2:191523923-191523924(+) m6A CDS//intron       24981863//22608085 chr2:191524122-191524123(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr2:191524134-191524135(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr2:191524267-191524268(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:191524321-191524322(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:191524378-191524379(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:191524431-191524432(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:191524571-191524572(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:191524702-191524703(+) m6A CDS//exon       24284625//22608085 chr2:191550263-191550264(+) m6A CDS       - chr2:191550359-191550360(+) m6A CDS       - chr2:191551933-191551934(+) m6A CDS       - chr2:191551965-191551966(+) m6A CDS       24284625 chr2:191552008-191552009(+) m6A CDS       24284625//24981863 chr2:191554991-191554992(+) m6A CDS       24284625//24981863//22608085 chr2:191555035-191555036(+) m6A CDS       24284625//24981863//22608085 chr2:191555162-191555163(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr2:191555188-191555189(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr2:191555210-191555211(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr2:191555224-191555225(+) m6A 3'UTR       24284625//25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	NAB1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: NAB1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.