Detail Information

Basic Information:


  VIRBase ID:  

HHID00071091

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:           JAK3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-320d JAK3
miRBase
Accession/Entrez ID		 MIMAT0006764 3718
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - JAK-3//JAK3_HUMAN//JAKL//L-JAK//LJAK

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-320d
rs1013069487 chr13:40727828    T/C
rs1212045422 chr13:40727836    ACC/A
rs1287962814 chr13:40727836    A/G
rs755131134 chr13:40727846    T/C
rs757049836 chr13:40727829    C/A
rs757049836 chr13:40727829    C/T
rs772990558 chr13:40727831    T/C
rs1441164440 chrX:140926173    C/G
rs1556096982 chrX:140926178    C/G
rs782742486 chrX:140926174    C/G
rs782742486 chrX:140926174    C/T
rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T
rs535778068 chr13:40727842    C/G
rs569951817 chr13:40727839    C/T
rs1330731340 chrX:140926183    C/G
rs1384057774 chrX:140926185    G/A
rs1422735584 chrX:140926184    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR JAK3
chr19:17938664(-) A-I      intronic
chr19:17938628(-) A-I      intronic
chr19:17938629(-) A-I      intronic
chr19:17938635(-) A-I      intronic
chr19:17938654(-) A-I      intronic
chr19:17938665(-) A-I      intronic
chr19:17939176(-) A-I      intronic
chr19:17939190(-) A-I      intronic
chr19:17939193(-) A-I      intronic
chr19:17939213(-) A-I      intronic
chr19:17939314(-) A-I      intronic
chr19:17939347(-) A-I      intronic
chr19:17939707(-) A-I      intronic
chr19:17939937(-) A-I      intronic
chr19:17939938(-) A-I      intronic
chr19:17940500(-) A-I      intronic
chr19:17942840(-) A-I      intronic
chr19:17942879(-) A-I      intronic
chr19:17942971(-) A-I      intronic
chr19:17942988(-) A-I      intronic
chr19:17942989(-) A-I      intronic
chr19:17942994(-) A-I      intronic
chr19:17944748(-) A-I      intronic
chr19:17944824(-) A-I      intronic
chr19:17949466(-) A-I      intronic
chr19:17951316(-) A-I      intronic
chr19:17951414(-) A-I      intronic
chr19:17951450(-) A-I      intronic
chr19:17951528(-) A-I      intronic
chr19:17951792(-) A-I      intronic
chr19:17951827(-) A-I      intronic
chr19:17951905(-) A-I      intronic
chr19:17955391(-) A-I      intronic
chr19:17956374(-) A-I      intronic
chr19:17956380(-) A-I      intronic
chr19:17956551(-) A-I      intronic
chr19:17956800(-) A-I      intronic
chr19:17957472(-) A-I      intronic
chr19:17957573(-) A-I      intronic
chr19:17957645(-) A-I      intronic
chr19:17957973(-) A-I      intronic
chr19:17957974(-) A-I      intronic
chr19:17958311(-) A-I      intronic
chr19:17937851(-) A-I      intronic
chr19:17937856(-) A-I      intronic
chr19:17937929(-) A-I      intronic
chr19:17938000(-) A-I      intronic
chr19:17938295(-) A-I      intronic
chr19:17938349(-) A-I      intronic
chr19:17938372(-) A-I      intronic
chr19:17936914(-) A-I      3'UTR
chr19:17937013(-) A-I      3'UTR
chr19:17937082(-) A-I      3'UTR
chr19:17936541(-) A-I      3'UTR
chr19:17936937(-) A-I      3'UTR
chr19:17937062(-) A-I      3'UTR
chr19:17936958(-) A-I      3'UTR
chr19:17936659(-) A-I      3'UTR
chr19:17937027(-) A-I      3'UTR
chr19:17936948(-) A-I      3'UTR
chr19:17937112(-) A-I      3'UTR
chr19:17936610(-) A-I      3'UTR
chr19:17936949(-) A-I      3'UTR
chr19:17937156(-) A-I      3'UTR
chr19:17936529(-) A-I      3'UTR
chr19:17937094(-) A-I      3'UTR
chr19:17936570(-) A-I      3'UTR
chr19:17936468(-) A-I      3'UTR
chr19:17937168(-) A-I      3'UTR
chr19:17936975(-) A-I      3'UTR
chr19:17936467(-) A-I      3'UTR
chr19:17936663(-) A-I      3'UTR
chr19:17936647(-) A-I      3'UTR
chr19:17936588(-) A-I      3'UTR
chr19:17936452(-) A-I      3'UTR
chr19:17937054(-) A-I      3'UTR
chr19:17936674(-) A-I      3'UTR
chr19:17944299(-) A-I      intronic
chr19:17940460(-) A-I      intronic
chr19:17937953(-) A-I      intronic
chr19:17940224(-) A-I      intronic
chr19:17951765(-) A-I      intronic
chr19:17950839(-) A-I      intronic
chr19:17937796(-) A-I      intronic
chr19:17939141(-) A-I      intronic
chr19:17938268(-) A-I      intronic
chr19:17951383(-) A-I      intronic
chr19:17955478(-) A-I      intronic
chr19:17948573(-) A-I      intronic
chr19:17939930(-) A-I      intronic
chr19:17939282(-) A-I      intronic
chr19:17945158(-) A-I      intronic
chr19:17940507(-) A-I      intronic
chr19:17940247(-) A-I      intronic
chr19:17944779(-) A-I      intronic
chr19:17956845(-) A-I      intronic
chr19:17937192(-) A-I      3'UTR
chr19:17936454(-) A-I      3'UTR
chr19:17938242(-) A-I      intronic
chr19:17950546(-) A-I      intronic
chr19:17956236(-) A-I      intronic
chr19:17936602(-) A-I      3'UTR
chr19:17951759(-) A-I      intronic
chr19:17937188(-) A-I      3'UTR
chr19:17937111(-) A-I      3'UTR
chr19:17939470(-) A-I      intronic
chr19:17937070(-) A-I      3'UTR
chr19:17939162(-) A-I      intronic
chr19:17938521(-) A-I      intronic
chr19:17940457(-) A-I      intronic
chr19:17938526(-) A-I      intronic
chr19:17937072(-) A-I      3'UTR
chr19:17939473(-) A-I      intronic
chr19:17956295(-) A-I      intronic
chr19:17940375(-) A-I      intronic
chr19:17944806(-) A-I      intronic
chr19:17936934(-) A-I      3'UTR
chr19:17939746(-) A-I      intronic
chr19:17936466(-) A-I      3'UTR
chr19:17937885(-) A-I      intronic
chr19:17940239(-) A-I      intronic
chr19:17939720(-) A-I      intronic
chr19:17936982(-) A-I      3'UTR
chr19:17937137(-) A-I      3'UTR
chr19:17939307(-) A-I      intronic
chr19:17937118(-) A-I      3'UTR
chr19:17940517(-) A-I      intronic
chr19:17936521(-) A-I      3'UTR
chr19:17948570(-) A-I      intronic
chr19:17939416(-) A-I      intronic
chr19:17936546(-) A-I      3'UTR
chr19:17956759(-) A-I      intronic
chr19:17938063(-) A-I      intronic
chr19:17949427(-) A-I      intronic
chr19:17936601(-) A-I      3'UTR
chr19:17937886(-) A-I      intronic
chr19:17938294(-) A-I      intronic
chr19:17938217(-) A-I      intronic
chr19:17939047(-) A-I      intronic
chr19:17939327(-) A-I      intronic
chr19:17938599(-) A-I      intronic
chr19:17951898(-) A-I      intronic
chr19:17938249(-) A-I      intronic
chr19:17940474(-) A-I      intronic
chr19:17937822(-) A-I      intronic
chr19:17938672(-) A-I      intronic
chr19:17945079(-) A-I      intronic
chr19:17940349(-) A-I      intronic
chr19:17956764(-) A-I      intronic
chr19:17940447(-) A-I      intronic
chr19:17940240(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED JAK3
chr19:17937188(-) A-I exon 3'UTR    22327324
chr19:17936521(-) A-G exon 3'UTR    21725310   //22484847
chr19:17936793(-) C-T exon 3'UTR    22484847
chr19:17936982(-) A-G exon 3'UTR    22484847
chr19:17936995(-) A-G exon 3'UTR    22484847
chr19:17937137(-) A-G exon 3'UTR    22484847
chr19:17937172(-) A-G exon 3'UTR    22484847
chr19:17937188(-) A-G exon 3'UTR    22484847
chr19:17937192(-) A-G exon 3'UTR    22484847
chr19:17937953(-) A-G intron -    22484847
chr19:17939282(-) A-G intron -    22484847
chr19:17939307(-) A-G intron -    22484847
chr19:17939720(-) A-G intron -    22484847
chr19:17940457(-) A-G intron -    22484847
chr19:17944806(-) A-G intron -    22484847
chr19:17951383(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase JAK3
chr19:17935808-17935809(-) m6A 3'UTR//exon       -
chr19:17935828-17935829(-) m6A 3'UTR//exon       -
chr19:17936987-17936988(-) m6A 3'UTR//intron       -
chr19:17953466-17953467(-) m6A exon//intron       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-320d
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Plasma     23663360
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
JAK3
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-320d
Eloxatine 5310940 Drug interaction    RC00007888
5-Fluorouracil 3385 Drug interaction    RC00007885
Doxorubicin 31703 Drug interaction    RC00007886
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884
Docetaxel 148124 Drug interaction    RC00007887
Marine fungal metabolite 1386A - Drug interaction    RC00007889
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-320d
Topotecan       60700
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-320d
Interactor2: JAK3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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