Detail Information

Basic Information:


  VIRBase ID:  

HHID00071089

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:           HLA-DPA1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-320d HLA-DPA1
miRBase
Accession/Entrez ID		 MIMAT0006764 3113
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DP(W3)//DP(W4)//DPA1//HLA-DP1A//HLA-DPA//HLA-DPB1//HLADP//HLASB//PLT1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-320d
rs1013069487 chr13:40727828    T/C
rs1212045422 chr13:40727836    ACC/A
rs1287962814 chr13:40727836    A/G
rs755131134 chr13:40727846    T/C
rs757049836 chr13:40727829    C/A
rs757049836 chr13:40727829    C/T
rs772990558 chr13:40727831    T/C
rs1441164440 chrX:140926173    C/G
rs1556096982 chrX:140926178    C/G
rs782742486 chrX:140926174    C/G
rs782742486 chrX:140926174    C/T
rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T
rs535778068 chr13:40727842    C/G
rs569951817 chr13:40727839    C/T
rs1330731340 chrX:140926183    C/G
rs1384057774 chrX:140926185    G/A
rs1422735584 chrX:140926184    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HLA-DPA1
chr6:33032815-33032816(-) m6A 3'UTR//exon       28052920
chr6:33032850-33032851(-) m6A 3'UTR//exon       28052920
chr6:33037470-33037471(-) m6A CDS//exon       -
chr6:33037549-33037550(-) m6A CDS//exon       -
chr6:33037560-33037561(-) m6A CDS//exon       -
chr6:33037619-33037620(-) m6A CDS//exon       -
chr6:33037659-33037660(-) m6A CDS//exon       -
chr6:33041333-33041334(-) m6A CDS//exon//intron       24981863//28052920
chr6:33041356-33041357(-) m6A 5'UTR//exon//intron       24981863//28052920

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-320d
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Plasma     23663360
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
HLA-DPA1
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-320d
Eloxatine 5310940 Drug interaction    RC00007888
5-Fluorouracil 3385 Drug interaction    RC00007885
Doxorubicin 31703 Drug interaction    RC00007886
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884
Docetaxel 148124 Drug interaction    RC00007887
Marine fungal metabolite 1386A - Drug interaction    RC00007889
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-320d
Topotecan       60700
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-320d
Interactor2: HLA-DPA1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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