Basic Information:

  VIRBase ID:  

HHID00071080

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320d:  MIMAT0006764          ARHGAP5:  NM_001173     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320d	ARHGAP5
miRBase Accession/Entrez ID	MIMAT0006764	394
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GFI2//p190-B//p190BRhoGAP//RhoGAP5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320d	rs1013069487 chr13:40727828    T/C rs1212045422 chr13:40727836    ACC/A rs1287962814 chr13:40727836    A/G rs755131134 chr13:40727846    T/C rs757049836 chr13:40727829    C/A rs757049836 chr13:40727829    C/T rs772990558 chr13:40727831    T/C rs1441164440 chrX:140926173    C/G rs1556096982 chrX:140926178    C/G rs782742486 chrX:140926174    C/G rs782742486 chrX:140926174    C/T rs1371780032 chr13:40727825    TCATCCTCTCAACCCAGC/T rs535778068 chr13:40727842    C/G rs569951817 chr13:40727839    C/T rs1330731340 chrX:140926183    C/G rs1384057774 chrX:140926185    G/A rs1422735584 chrX:140926184    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARHGAP5	chr14:32622436(+) A-I      intronic chr14:32615394(+) A-I      intronic chr14:32615364(+) A-I      intronic chr14:32615351(+) A-I      intronic chr14:32607619(+) A-I      intronic chr14:32607673(+) A-I      intronic chr14:32607655(+) A-I      intronic chr14:32569485(+) A-I      intronic chr14:32622442(+) A-I      intronic chr14:32622455(+) A-I      intronic chr14:32569433(+) A-I      intronic chr14:32603814(+) A-I      intronic chr14:32622893(+) A-I      intronic chr14:32569605(+) A-I      intronic chr14:32606991(+) A-I      intronic chr14:32606954(+) A-I      intronic chr14:32604818(+) A-I      intronic chr14:32599224(+) A-I      intronic chr14:32599218(+) A-I      intronic chr14:32587532(+) A-I      intronic chr14:32587455(+) A-I      intronic chr14:32587450(+) A-I      intronic chr14:32585408(+) A-I      intronic chr14:32585378(+) A-I      intronic chr14:32584813(+) A-I      intronic chr14:32584661(+) A-I      intronic chr14:32584658(+) A-I      intronic chr14:32622844(+) A-I      intronic chr14:32584650(+) A-I      intronic chr14:32581829(+) A-I      intronic chr14:32581208(+) A-I      intronic chr14:32581205(+) A-I      intronic chr14:32579548(+) A-I      intronic chr14:32570989(+) A-I      intronic chr14:32569547(+) A-I      intronic chr14:32569505(+) A-I      intronic chr14:32584615(+) A-I      intronic chr14:32622533(+) A-I      intronic chr14:32570928(+) A-I      intronic chr14:32615254(+) A-I      intronic chr14:32581222(+) A-I      intronic chr14:32569545(+) A-I      intronic chr14:32569669(+) A-I      intronic chr14:32581921(+) A-I      intronic chr14:32622451(+) A-I      intronic chr14:32581925(+) A-I      intronic chr14:32609685(+) A-I      intronic chr14:32609610(+) A-I      intronic chr14:32569678(+) A-I      intronic chr14:32622859(+) A-I      intronic chr14:32622437(+) A-I      intronic chr14:32622463(+) A-I      intronic chr14:32583313(+) A-I      intronic chr14:32615338(+) A-I      intronic chr14:32622558(+) A-I      intronic chr14:32583179(+) A-I      intronic chr14:32622836(+) A-I      intronic chr14:32622782(+) A-I      intronic chr14:32622597(+) A-I      intronic chr14:32622454(+) A-I      intronic chr14:32618469(+) A-I      intronic chr14:32618457(+) A-I      intronic chr14:32612673(+) A-I      intronic chr14:32612672(+) A-I      intronic chr14:32612661(+) A-I      intronic chr14:32612657(+) A-I      intronic chr14:32612641(+) A-I      intronic chr14:32612588(+) A-I      intronic chr14:32612513(+) A-I      intronic chr14:32609682(+) A-I      intronic chr14:32609641(+) A-I      intronic chr14:32607664(+) A-I      intronic chr14:32607589(+) A-I      intronic chr14:32607514(+) A-I      intronic chr14:32607508(+) A-I      intronic chr14:32607016(+) A-I      intronic chr14:32607002(+) A-I      intronic chr14:32606992(+) A-I      intronic chr14:32581285(+) A-I      intronic chr14:32569651(+) A-I      intronic chr14:32581947(+) A-I      intronic chr14:32585438(+) A-I      intronic chr14:32581854(+) A-I      intronic chr14:32607099(+) A-I      intronic chr14:32612553(+) A-I      intronic chr14:32585678(+) A-I      intronic chr14:32581924(+) A-I      intronic chr14:32569626(+) A-I      intronic chr14:32622779(+) A-I      intronic chr14:32623496(+) A-I      intronic chr14:32581891(+) A-I      intronic chr14:32622862(+) A-I      intronic chr14:32622808(+) A-I      intronic chr14:32622554(+) A-I      intronic chr14:32622555(+) A-I      intronic chr14:32607662(+) A-I      intronic chr14:32571069(+) A-I      intronic chr14:32612635(+) A-I      intronic chr14:32615339(+) A-I      intronic chr14:32579547(+) A-I      intronic chr14:32609675(+) A-I      intronic chr14:32569567(+) A-I      intronic chr14:32622453(+) A-I      intronic chr14:32623077(+) A-I      intronic chr14:32580409(+) A-I      intronic chr14:32581901(+) A-I      intronic chr14:32579550(+) A-I      intronic chr14:32581234(+) A-I      intronic chr14:32622505(+) A-I      intronic chr14:32581821(+) A-I      intronic chr14:32564802(+) A-I      intronic chr14:32569672(+) A-I      intronic chr14:32618474(+) A-I      intronic chr14:32585443(+) A-I      intronic chr14:32606958(+) A-I      intronic chr14:32569587(+) A-I      intronic chr14:32581164(+) A-I      intronic chr14:32569506(+) A-I      intronic chr14:32570935(+) A-I      intronic chr14:32623434(+) A-I      intronic chr14:32581088(+) A-I      intronic chr14:32607590(+) A-I      intronic chr14:32615391(+) A-I      intronic chr14:32599827(+) A-I      intronic chr14:32622850(+) A-I      intronic chr14:32570988(+) A-I      intronic chr14:32622508(+) A-I      intronic chr14:32615307(+) A-I      intronic chr14:32569625(+) A-I      intronic chr14:32606923(+) A-I      intronic chr14:32569457(+) A-I      intronic chr14:32582196(+) A-I      intronic chr14:32604648(+) A-I      intronic chr14:32622818(+) A-I      intronic chr14:32554527(+) A-I      intronic chr14:32581956(+) A-I      intronic chr14:32579594(+) A-I      intronic chr14:32622541(+) A-I      intronic chr14:32607710(+) A-I      intronic chr14:32618442(+) A-I      intronic chr14:32579601(+) A-I      intronic chr14:32615309(+) A-I      intronic chr14:32622868(+) A-I      intronic chr14:32569539(+) A-I      intronic chr14:32617228(+) A-I      intronic chr14:32622452(+) A-I      intronic chr14:32569640(+) A-I      intronic chr14:32612578(+) A-I      intronic chr14:32583277(+) A-I      intronic chr14:32607607(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARHGAP5	chr14:32622862(+) A-I intron -    22327324 chr14:32570988(+) A-G intron -    22484847 chr14:32571016(+) C-T intron -    22484847 chr14:32571021(+) T-C intron -    22484847 chr14:32571069(+) A-G intron -    22484847 chr14:32622862(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARHGAP5	chr14:32545386-32545387(+) m6A 5'UTR       27773535 chr14:32545695-32545696(+) m6A 5'UTR       24284625//24981863//27773535//22608085 chr14:32545701-32545702(+) m6A 5'UTR       24284625//24981863//27773535//22608085 chr14:32545788-32545789(+) m6A 5'UTR       24284625//24981863//27773535 chr14:32546627-32546628(+) m6A 5'UTR//CDS//intron       24209618//24981863//27773535 chr14:32559766-32559767(+) m6A 5'UTR//intron       27773535//22575960//22608085 chr14:32559859-32559860(+) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32559888-32559889(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32559931-32559932(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32559941-32559942(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32559951-32559952(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32560077-32560078(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32560156-32560157(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32560181-32560182(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32560261-32560262(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32560297-32560298(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32560302-32560303(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32560309-32560310(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32560450-32560451(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32560536-32560537(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32560553-32560554(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32560583-32560584(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32560619-32560620(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr14:32560664-32560665(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32560672-32560673(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32560708-32560709(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr14:32560718-32560719(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32560748-32560749(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32560808-32560809(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32560837-32560838(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32560846-32560847(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32560855-32560856(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32560861-32560862(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32560945-32560946(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32561024-32561025(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr14:32561039-32561040(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr14:32561052-32561053(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32561121-32561122(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr14:32561183-32561184(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr14:32561371-32561372(+) m6A CDS//intron       24981863//22608085 chr14:32561540-32561541(+) m6A CDS//intron       27773535//22608085 chr14:32561568-32561569(+) m6A CDS//intron       27773535//22608085 chr14:32561701-32561702(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32561720-32561721(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr14:32561767-32561768(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32561822-32561823(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32561836-32561837(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32561912-32561913(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr14:32562042-32562043(+) m6A CDS//intron       24284625//27773535//22608085 chr14:32562104-32562105(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32562148-32562149(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr14:32562189-32562190(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr14:32562307-32562308(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr14:32562412-32562413(+) m6A CDS//intron       24284625//24981863//22608085 chr14:32562498-32562499(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32562589-32562590(+) m6A CDS//intron       27773535//22608085 chr14:32562656-32562657(+) m6A CDS//intron       24981863//27773535//22608085 chr14:32562786-32562787(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32562951-32562952(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32562997-32562998(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr14:32563003-32563004(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr14:32563019-32563020(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr14:32563033-32563034(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32563044-32563045(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32563055-32563056(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32563094-32563095(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:32563153-32563154(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr14:32563174-32563175(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr14:32563242-32563243(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32563295-32563296(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32563349-32563350(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32563385-32563386(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr14:32563430-32563431(+) m6A CDS//intron       24981863//27773535//22608085 chr14:32563447-32563448(+) m6A CDS//intron       24981863//27773535//22608085 chr14:32563490-32563491(+) m6A CDS//intron       24981863//27773535//22608085 chr14:32563565-32563566(+) m6A CDS//intron       24981863//27773535//22608085 chr14:32586357-32586358(+) m6A 5'UTR//CDS//intron       24981863//27773535 chr14:32586364-32586365(+) m6A 5'UTR//CDS//intron       24981863//27773535 chr14:32619222-32619223(+) m6A 3'UTR//CDS       27773535 chr14:32621642-32621643(+) m6A 3'UTR//CDS       27773535 chr14:32621694-32621695(+) m6A 3'UTR//CDS       27773535 chr14:32621730-32621731(+) m6A 3'UTR//CDS       27773535 chr14:32623311-32623312(+) m6A exon//intron       27773535 chr14:32623864-32623865(+) m6A 3'UTR//CDS//exon       24284625//27773535//22608085 chr14:32623901-32623902(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr14:32623962-32623963(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085 chr14:32624020-32624021(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr14:32624047-32624048(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr14:32624054-32624055(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr14:32624066-32624067(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr14:32624171-32624172(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr14:32624186-32624187(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr14:32624203-32624204(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr14:32624283-32624284(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr14:32624996-32624997(+) m6A 3'UTR//exon       27773535 chr14:32625068-32625069(+) m6A 3'UTR//exon       27773535 chr14:32625098-32625099(+) m6A 3'UTR//exon       27773535 chr14:32625103-32625104(+) m6A 3'UTR//exon       27773535 chr14:32625118-32625119(+) m6A 3'UTR//exon       27773535 chr14:32625381-32625382(+) m6A 3'UTR//exon       27773535 chr14:32625403-32625404(+) m6A 3'UTR//exon       27773535 chr14:32625409-32625410(+) m6A 3'UTR//exon       27773535 chr14:32625678-32625679(+) m6A 3'UTR//exon       27773535 chr14:32626028-32626029(+) m6A 3'UTR//exon       27773535 chr14:32626040-32626041(+) m6A 3'UTR//exon       27773535 chr14:32626105-32626106(+) m6A 3'UTR//exon       27773535 chr14:32626240-32626241(+) m6A 3'UTR//exon       27773535 chr14:32626289-32626290(+) m6A 3'UTR//exon       27773535 chr14:32626490-32626491(+) m6A 3'UTR       27773535 chr14:32626500-32626501(+) m6A 3'UTR       27773535 chr14:32626518-32626519(+) m6A 3'UTR       27773535 chr14:32626560-32626561(+) m6A 3'UTR       27773535 chr14:32626574-32626575(+) m6A 3'UTR       27773535 chr14:32626622-32626623(+) m6A 3'UTR       27773535 chr14:32627092-32627093(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320d	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	ARHGAP5	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320d	Eloxatine 5310940 Drug interaction    RC00007888 5-Fluorouracil 3385 Drug interaction    RC00007885 Doxorubicin 31703 Drug interaction    RC00007886 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007884 Docetaxel 148124 Drug interaction    RC00007887 Marine fungal metabolite 1386A - Drug interaction    RC00007889

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320d	Topotecan       60700 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320d
Interactor2: ARHGAP5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.