Basic Information:

  VIRBase ID:  

HHID00071055

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-664a-3p:  MIMAT0005949          CASP7:  NM_001320911     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-664a-3p	CASP7
miRBase Accession/Entrez ID	MIMAT0005949	840
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CASP-7//CMH-1//ICE-LAP3//LICE2//MCH3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-664a-3p	rs1167925254 chr1:220200550    G/T rs1170225715 chr1:220200557    G/T rs1313271494 chr1:220200553    G/T rs1368463251 chr1:220200551    TAGGC/T rs1377901643 chr1:220200554    G/T rs1393962832 chr1:220200555    C/CTTTTTT rs1404740911 chr1:220200556    T/C rs1416447585 chr1:220200552    A/T rs746047168 chr1:220200558    G/A rs770101636 chr1:220200560    G/T rs1042905485 chr1:220200567    G/A rs1229753248 chr1:220200564    A/T rs1478242335 chr1:220200570    T/C rs908858734 chr1:220200566    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CASP7	chr10:115482552(+) A-I      intronic chr10:115475392(+) A-I      intronic chr10:115482563(+) A-I      intronic chr10:115482556(+) A-I      intronic chr10:115461170(+) A-I      intronic chr10:115477103(+) A-I      intronic chr10:115475308(+) A-I      intronic chr10:115475331(+) A-I      intronic chr10:115477195(+) A-I      intronic chr10:115477175(+) A-I      intronic chr10:115458250(+) A-I      intronic chr10:115458309(+) A-I      intronic chr10:115477102(+) A-I      intronic chr10:115461261(+) A-I      intronic chr10:115474283(+) A-I      intronic chr10:115482506(+) A-I      intronic chr10:115458337(+) A-I      intronic chr10:115467702(+) A-I      intronic chr10:115474785(+) A-I      intronic chr10:115474248(+) A-I      intronic chr10:115474278(+) A-I      intronic chr10:115474837(+) A-I      intronic chr10:115482441(+) A-I      intronic chr10:115467604(+) A-I      intronic chr10:115458252(+) A-I      intronic chr10:115474312(+) A-I      intronic chr10:115461256(+) A-I      intronic chr10:115458301(+) A-I      intronic chr10:115458227(+) A-I      intronic chr10:115477181(+) A-I      intronic chr10:115474798(+) A-I      intronic chr10:115458258(+) A-I      intronic chr10:115477035(+) A-I      intronic chr10:115483337(+) A-I      intronic chr10:115467614(+) A-I      intronic chr10:115475478(+) A-I      intronic chr10:115475444(+) A-I      intronic chr10:115458251(+) A-I      intronic chr10:115482525(+) A-I      intronic chr10:115467696(+) A-I      intronic chr10:115461272(+) A-I      intronic chr10:115482503(+) A-I      intronic chr10:115461163(+) A-I      intronic chr10:115477182(+) A-I      intronic chr10:115475295(+) A-I      intronic chr10:115483418(+) A-I      intronic chr10:115481697(+) A-I      intronic chr10:115482481(+) A-I      intronic chr10:115482494(+) A-I      intronic chr10:115481712(+) A-I      intronic chr10:115458176(+) A-I      intronic chr10:115477028(+) A-I      intronic chr10:115458292(+) A-I      intronic chr10:115457719(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CASP7	chr10:115458438(+) A-T intron -    22484847 chr10:115458441(+) A-T intron -    22484847 chr10:115458176(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CASP7	chr10:115439061-115439062(+) m6A 5'UTR       24981863 chr10:115439638-115439639(+) m6A 5'UTR//CDS//intron       24981863 chr10:115439672-115439673(+) m6A 5'UTR//CDS//intron       24981863 chr10:115439699-115439700(+) m6A 5'UTR//CDS//intron       24981863 chr10:115451734-115451735(+) m6A 5'UTR//CDS//intron       24981863 chr10:115451779-115451780(+) m6A 5'UTR//CDS//intron       24981863 chr10:115457331-115457332(+) m6A CDS       24981863 chr10:115469132-115469133(+) m6A 5'UTR//intron       - chr10:115480900-115480901(+) m6A CDS//exon       26404942 chr10:115480909-115480910(+) m6A CDS//exon       26404942 chr10:115489150-115489151(+) m6A CDS//exon       24981863 chr10:115489280-115489281(+) m6A 3'UTR//CDS       24981863 chr10:115489563-115489564(+) m6A 3'UTR       24981863 chr10:115489857-115489858(+) m6A 3'UTR       27773535 chr10:115489863-115489864(+) m6A 3'UTR       27773535 chr10:115489937-115489938(+) m6A 3'UTR       24209618//24981863//26404942//27773535//22608085 chr10:115490033-115490034(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr10:115490065-115490066(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr10:115490103-115490104(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:115490136-115490137(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:115490232-115490233(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:115490250-115490251(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr10:115490269-115490270(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr10:115490304-115490305(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr10:115490387-115490388(+) m6A 3'UTR       26404942//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-664a-3p	Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	CASP7	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-664a-3p	Eloxatine 5310940 Drug interaction    RC00007857 Imatinib 5291 Drug interaction    RC00007853 Doxorubicin 31703 Drug interaction    RC00007854 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00007858 Sorafenib 216239 Drug interaction    RC00007856 Ginsenoside Rh2 119307 Drug interaction    RC00007855

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-664a-3p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-664a-3p
Interactor2: CASP7

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.