Detail Information

Basic Information:


  VIRBase ID:  

HHID00070962

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1274b PDCD4
miRBase
Accession/Entrez ID		 MIMAT0005938 27250
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - H731

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PDCD4
chr10:112650922(+) A-I      intronic
chr10:112636041(+) A-I      intronic
chr10:112639276(+) A-I      intronic
chr10:112650998(+) A-I      intronic
chr10:112639286(+) A-I      intronic
chr10:112635876(+) A-I      intronic
chr10:112635992(+) A-I      intronic
chr10:112635991(+) A-I      intronic
chr10:112635900(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PDCD4
chr10:112639276(+) A-G intron -    22484847
chr10:112639286(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PDCD4
chr10:112631658-112631659(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr10:112631664-112631665(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr10:112631689-112631690(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr10:112631711-112631712(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr10:112631745-112631746(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr10:112635819-112635820(+) m6A 5'UTR//CDS//exon//intron       24209618//24981863
chr10:112641043-112641044(+) m6A CDS//exon       22608085
chr10:112641143-112641144(+) m6A CDS//exon       24981863//22575960//22608085
chr10:112641155-112641156(+) m6A CDS//exon       24981863//22575960//22608085
chr10:112641279-112641280(+) m6A CDS//exon       24981863//22575960//22608085
chr10:112642797-112642798(+) m6A CDS//exon       24981863//27773535//22575960
chr10:112645028-112645029(+) m6A CDS//exon       22575960
chr10:112645067-112645068(+) m6A CDS//exon       22575960
chr10:112657830-112657831(+) m6A CDS//exon       26404942
chr10:112657854-112657855(+) m6A 3'UTR//exon       26404942
chr10:112658366-112658367(+) m6A 3'UTR//exon       27773535
chr10:112658388-112658389(+) m6A 3'UTR//exon       27773535
chr10:112658393-112658394(+) m6A 3'UTR//exon       27773535
chr10:112658417-112658418(+) m6A 3'UTR//exon       27773535
chr10:112658436-112658437(+) m6A 3'UTR//exon       27773535
chr10:112658449-112658450(+) m6A 3'UTR//exon       27773535
chr10:112658482-112658483(+) m6A 3'UTR       27773535
chr10:112658537-112658538(+) m6A 3'UTR       27773535
chr10:112658587-112658588(+) m6A 3'UTR       27773535
chr10:112658621-112658622(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate PDCD4
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1274b
Eloxatine 5310940 Drug interaction    RC00007833
Sorafenib 216239 Drug interaction    RC00007832
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1274b
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Nvp-aew541       11476171

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1274b
Interactor2: PDCD4

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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