Detail Information

Basic Information:


  VIRBase ID:  

HHID00070956

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1274b SYPL1
miRBase
Accession/Entrez ID		 MIMAT0005938 6856
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - H-SP1//SYPL

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SYPL1
chr7:105735796(-) A-I intron -    21960545
chr7:105746823(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SYPL1
chr7:105732132-105732133(-) Y 3'UTR       26075521
chr7:105733472-105733473(-) m6A 3'UTR//CDS//exon       26404942
chr7:105753005-105753006(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SYPL1
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1274b
Eloxatine 5310940 Drug interaction    RC00007833
Sorafenib 216239 Drug interaction    RC00007832
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1274b
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Nvp-aew541       11476171

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1274b
Interactor2: SYPL1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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