Detail Information

Basic Information:


  VIRBase ID:  

HHID00070954

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1274b NAP1L1
miRBase
Accession/Entrez ID		 MIMAT0005938 4673
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - NAP1//NAP1L//NRP

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NAP1L1
chr12:76470650(-) A-I      intronic
chr12:76450566(-) A-I      intronic
chr12:76445412(-) A-I      intronic
chr12:76475309(-) A-I      intronic
chr12:76473536(-) A-I      intronic
chr12:76450679(-) A-I      intronic
chr12:76473193(-) A-I      intronic
chr12:76452407(-) A-I      intronic
chr12:76450672(-) A-I      intronic
chr12:76451034(-) A-I      intronic
chr12:76451026(-) A-I      intronic
chr12:76450978(-) A-I      intronic
chr12:76450680(-) A-I      intronic
chr12:76473548(-) A-I      intronic
chr12:76473212(-) A-I      intronic
chr12:76464770(-) A-I      intronic
chr12:76450644(-) A-I      intronic
chr12:76473513(-) A-I      intronic
chr12:76473084(-) A-I      intronic
chr12:76445418(-) A-I      intronic
chr12:76452438(-) A-I      intronic
chr12:76450536(-) A-I      intronic
chr12:76464112(-) A-I      intronic
chr12:76464160(-) A-I      intronic
chr12:76471741(-) A-I      intronic
chr12:76445792(-) A-I      intronic
chr12:76451064(-) A-I      intronic
chr12:76473217(-) A-I      intronic
chr12:76473521(-) A-I      intronic
chr12:76450527(-) A-I      intronic
chr12:76451044(-) A-I      intronic
chr12:76452263(-) A-I      intronic
chr12:76452272(-) A-I      intronic
chr12:76452439(-) A-I      intronic
chr12:76450708(-) A-I      intronic
chr12:76445625(-) A-I      intronic
chr12:76445627(-) A-I      intronic
chr12:76473164(-) A-I      intronic
chr12:76452455(-) A-I      intronic
chr12:76450990(-) A-I      intronic
chr12:76450625(-) A-I      intronic
chr12:76473602(-) A-I      intronic
chr12:76452338(-) A-I      intronic
chr12:76447915(-) A-I      intronic
chr12:76473588(-) A-I      intronic
chr12:76473579(-) A-I      intronic
chr12:76452269(-) A-I      intronic
chr12:76473699(-) A-I      intronic
chr12:76473134(-) A-I      intronic
chr12:76445358(-) A-I      intronic
chr12:76445629(-) A-I      intronic
chr12:76464125(-) A-I      intronic
chr12:76473682(-) A-I      intronic
chr12:76452295(-) A-I      intronic
chr12:76473180(-) A-I      intronic
chr12:76452395(-) A-I      intronic
chr12:76473088(-) A-I      intronic
chr12:76450533(-) A-I      intronic
chr12:76473049(-) A-I      intronic
chr12:76470682(-) A-I      intronic
chr12:76450626(-) A-I      intronic
chr12:76452264(-) A-I      intronic
chr12:76470624(-) A-I      intronic
chr12:76450709(-) A-I      intronic
chr12:76473242(-) A-I      intronic
chr12:76470611(-) A-I      intronic
chr12:76473197(-) A-I      intronic
chr12:76450624(-) A-I      intronic
chr12:76471507(-) A-I      intronic
chr12:76470658(-) A-I      intronic
chr12:76473762(-) A-I      intronic
chr12:76474293(-) A-I      intronic
chr12:76445574(-) A-I      intronic
chr12:76452278(-) A-I      intronic
chr12:76450609(-) A-I      intronic
chr12:76473566(-) A-I      intronic
chr12:76470673(-) A-I      intronic
chr12:76452371(-) A-I      intronic
chr12:76474238(-) A-I      intronic
chr12:76470608(-) A-I      intronic
chr12:76471678(-) A-I      intronic
chr12:76452255(-) A-I      intronic
chr12:76450600(-) A-I      intronic
chr12:76473673(-) A-I      intronic
chr12:76450534(-) A-I      intronic
chr12:76464144(-) A-I      intronic
chr12:76474215(-) A-I      intronic
chr12:76451008(-) A-I      intronic
chr12:76454869(-) A-I      intronic
chr12:76474235(-) A-I      intronic
chr12:76474318(-) A-I      intronic
chr12:76452331(-) A-I      intronic
chr12:76474286(-) A-I      intronic
chr12:76475295(-) A-I      intronic
chr12:76470601(-) A-I      intronic
chr12:76452337(-) A-I      intronic
chr12:76474300(-) A-I      intronic
chr12:76471513(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NAP1L1
chr12:76451511(-) A-I intron -    22327324
chr12:76470673(-) A-I intron -    22327324
chr12:76474215(-) A-I intron -    21960545   //22327324
chr12:76470624(-) A-I intron -    21960545
chr12:76470608(-) A-G intron -    22484847
chr12:76470611(-) A-G intron -    22484847
chr12:76470673(-) A-G intron -    22484847
chr12:76474215(-) A-G intron -    22484847
chr12:76474286(-) A-G intron -    22484847
chr12:76474293(-) A-G intron -    22484847
chr12:76474318(-) A-G intron -    22484847
chr12:76445418(-) A-G intron -    22484847
chr12:76445792(-) A-G intron -    22484847
chr12:76450527(-) A-G intron -    22484847
chr12:76450589(-) C-A intron -    22484847
chr12:76450609(-) A-G intron -    22484847
chr12:76450624(-) A-G intron -    22484847
chr12:76450625(-) A-G intron -    22484847
chr12:76450626(-) A-G intron -    22484847
chr12:76450644(-) A-G intron -    22484847
chr12:76451044(-) A-G intron -    22484847
chr12:76451064(-) A-G intron -    22484847
chr12:76452441(-) G-A intron -    22484847
chr12:76473164(-) A-G intron -    22484847
chr12:76473180(-) A-G intron -    22484847
chr12:76473197(-) A-G intron -    22484847
chr12:76473212(-) A-G intron -    22484847
chr12:76473242(-) A-G intron -    22484847
chr12:76473588(-) A-G intron -    22484847
chr12:76473682(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NAP1L1
chr12:76442159-76442160(-) m6A 3'UTR//intron       24981863//27773535//27371828
chr12:76442233-76442234(-) m6A 3'UTR//CDS//exon       25456834//24981863//28052920//27773535//27371828
chr12:76442788-76442789(-) m6A 3'UTR//intron       25456834//24981863//28052920//27773535//27371828
chr12:76442825-76442826(-) m6A 3'UTR//intron       25456834//24981863//28052920//27773535//27371828
chr12:76442992-76442993(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960
chr12:76443041-76443042(-) m6A 3'UTR//exon//intron       24981863//28052920//27773535//22575960
chr12:76444401-76444402(-) m6A 3'UTR//CDS//exon       22575960
chr12:76448858-76448859(-) m6A CDS//exon       24981863
chr12:76448867-76448868(-) m6A CDS//exon       24981863
chr12:76449882-76449883(-) m6A 5'UTR//CDS//exon       24981863//28052920//27773535
chr12:76450049-76450050(-) m6A exon//intron       24981863//27773535
chr12:76450055-76450056(-) m6A exon//intron       27773535
chr12:76453526-76453527(-) m6A exon//intron       24981863
chr12:76453601-76453602(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535//22575960
chr12:76453628-76453629(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535//22575960
chr12:76454017-76454018(-) m6A 5'UTR//CDS//exon       22575960
chr12:76461172-76461173(-) m6A CDS//intron       22575960
chr12:76461191-76461192(-) m6A CDS//intron       22575960
chr12:76462695-76462696(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr12:76462700-76462701(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr12:76462712-76462713(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr12:76462720-76462721(-) m1A 5'UTR//CDS//exon//intron       26863410//26863196
chr12:76462729-76462730(-) m1A 5'UTR//CDS//exon//intron       26863410//26863196
chr12:76462758-76462759(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr12:76462767-76462768(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr12:76467588-76467589(-) m6A exon//intron       24981863//27773535
chr12:76467642-76467643(-) m6A exon//intron       27773535
chr12:76467991-76467992(-) m6A 5'UTR//CDS//exon//intron       24981863
chr12:76477675-76477676(-) m6A 5'UTR//intron       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate NAP1L1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1274b
Eloxatine 5310940 Drug interaction    RC00007833
Sorafenib 216239 Drug interaction    RC00007832
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1274b
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Nvp-aew541       11476171

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1274b
Interactor2: NAP1L1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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