Basic Information:

  VIRBase ID:  

HHID00070795

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1276:  MIMAT0005930          TBRG1:  NR_016021     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1276	TBRG1
miRBase Accession/Entrez ID	MIMAT0005930	84897
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NIAM//TB-5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1276	rs372186220 chr15:85770551    C/T rs759704230 chr15:85770557    A/G rs949716743 chr15:85770550    T/C rs1469123493 chr15:85770565    T/C rs34381260 chr15:85770563    CT/C rs34381260 chr15:85770563    CT/CTT rs750237476 chr15:85770564    T/C rs764239400 chr15:85770562    T/C rs769744052 chr15:85770560    G/A rs775843960 chr15:85770561    C/A rs775843960 chr15:85770561    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TBRG1	chr11:124504434(+) A-I      3'UTR chr11:124504459(+) A-I      3'UTR chr11:124504463(+) A-I      3'UTR chr11:124504109(+) A-I      3'UTR chr11:124504433(+) A-I      3'UTR chr11:124504115(+) A-I      3'UTR chr11:124503611(+) A-I      3'UTR chr11:124503607(+) A-I      3'UTR chr11:124504472(+) A-I      3'UTR chr11:124504471(+) A-I      3'UTR chr11:124504469(+) A-I      3'UTR chr11:124504468(+) A-I      3'UTR chr11:124503587(+) A-I      3'UTR chr11:124503561(+) A-I      3'UTR chr11:124504083(+) A-I      3'UTR chr11:124504492(+) A-I      3'UTR chr11:124504476(+) A-I      3'UTR chr11:124504073(+) A-I      3'UTR chr11:124504079(+) A-I      3'UTR chr11:124504070(+) A-I      3'UTR chr11:124504436(+) A-I      3'UTR chr11:124504444(+) A-I      3'UTR chr11:124504119(+) A-I      3'UTR chr11:124504440(+) A-I      3'UTR chr11:124503570(+) A-I      3'UTR chr11:124503568(+) A-I      3'UTR chr11:124504099(+) A-I      3'UTR chr11:124503562(+) A-I      3'UTR chr11:124497459(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TBRG1	chr11:124492768-124492769(+) m6A 5'UTR//exon       24284625//25456834//24981863 chr11:124492893-124492894(+) m6A 5'UTR//exon       24284625//25456834//24981863 chr11:124492976-124492977(+) m6A 5'UTR//exon       24981863 chr11:124501965-124501966(+) m6A exon//intron       24284625 chr11:124501997-124501998(+) m6A 3'UTR//CDS//exon       24284625 chr11:124502061-124502062(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr11:124502134-124502135(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr11:124502186-124502187(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr11:124504151-124504152(+) m6A 3'UTR       24981863 chr11:124504182-124504183(+) m6A 3'UTR       24981863 chr11:124504220-124504221(+) m6A 3'UTR       24981863 chr11:124504234-124504235(+) m6A 3'UTR       24981863 chr11:124504240-124504241(+) m6A 3'UTR       24981863 chr11:124504246-124504247(+) m6A 3'UTR       24981863 chr11:124504258-124504259(+) m6A 3'UTR       24981863 chr11:124504279-124504280(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1276	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	TBRG1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1276
Interactor2: TBRG1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.