Detail Information

Basic Information:


  VIRBase ID:  

HHID00070768

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1276:           MRPL3:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1276 MRPL3
miRBase
Accession/Entrez ID		 MIMAT0005930 11222
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - COXPD9//MRL3//RPML3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1276
rs372186220 chr15:85770551    C/T
rs759704230 chr15:85770557    A/G
rs949716743 chr15:85770550    T/C
rs1469123493 chr15:85770565    T/C
rs34381260 chr15:85770563    CT/C
rs34381260 chr15:85770563    CT/CTT
rs750237476 chr15:85770564    T/C
rs764239400 chr15:85770562    T/C
rs769744052 chr15:85770560    G/A
rs775843960 chr15:85770561    C/A
rs775843960 chr15:85770561    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MRPL3
chr3:131211916(-) A-I      intronic
chr3:131197649(-) A-I      intronic
chr3:131184618(-) A-I      intronic
chr3:131197607(-) A-I      intronic
chr3:131197620(-) A-I      intronic
chr3:131193905(-) A-I      intronic
chr3:131198687(-) A-I      intronic
chr3:131198607(-) A-I      intronic
chr3:131198522(-) A-I      intronic
chr3:131197700(-) A-I      intronic
chr3:131194261(-) A-I      intronic
chr3:131193822(-) A-I      intronic
chr3:131197788(-) A-I      intronic
chr3:131193892(-) A-I      intronic
chr3:131194327(-) A-I      intronic
chr3:131197715(-) A-I      intronic
chr3:131197719(-) A-I      intronic
chr3:131193787(-) A-I      intronic
chr3:131198632(-) A-I      intronic
chr3:131197625(-) A-I      intronic
chr3:131194241(-) A-I      intronic
chr3:131198433(-) A-I      intronic
chr3:131194320(-) A-I      intronic
chr3:131197828(-) A-I      intronic
chr3:131197816(-) A-I      intronic
chr3:131197796(-) A-I      intronic
chr3:131197779(-) A-I      intronic
chr3:131194247(-) A-I      intronic
chr3:131193802(-) A-I      intronic
chr3:131194260(-) A-I      intronic
chr3:131193708(-) A-I      intronic
chr3:131193800(-) A-I      intronic
chr3:131197826(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MRPL3
chr3:131206292(-) A-G intron -    22484847
chr3:131197613(-) A-G intron -    22484847
chr3:131197615(-) A-G intron -    22484847
chr3:131197621(-) A-G intron -    22484847
chr3:131197732(-) A-G intron -    22484847
chr3:131197796(-) A-G intron -    22484847
chr3:131197816(-) A-G intron -    22484847
chr3:131197826(-) A-G intron -    22484847
chr3:131198431(-) A-G intron -    22484847
chr3:131198500(-) A-G intron -    22484847
chr3:131198632(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MRPL3
chr3:131181546-131181547(-) m6A 3'UTR//exon       27773535
chr3:131190035-131190036(-) m6A CDS//exon       27773535//22575960
chr3:131190046-131190047(-) m6A CDS//exon       27773535//22575960
chr3:131220699-131220700(-) m6A 5'UTR//CDS//intron       27773536
chr3:131221576-131221577(-) m6A CDS//exon//intron       24981863//27371828//27773536//22575960
chr3:131221728-131221729(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//26404942//27371828//27773536//22575960
chr3:131221770-131221771(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//27371828//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1276
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
MRPL3
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1276
Interactor2: MRPL3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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