Basic Information:

  VIRBase ID:  

HHID00070767

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1276:  MIMAT0005930          MSL3:  NM_078629     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1276	MSL3
miRBase Accession/Entrez ID	MIMAT0005930	10943
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MRSXBA//MRXS36//MRXSBA//MSL3L1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1276	rs372186220 chr15:85770551    C/T rs759704230 chr15:85770557    A/G rs949716743 chr15:85770550    T/C rs1469123493 chr15:85770565    T/C rs34381260 chr15:85770563    CT/C rs34381260 chr15:85770563    CT/CTT rs750237476 chr15:85770564    T/C rs764239400 chr15:85770562    T/C rs769744052 chr15:85770560    G/A rs775843960 chr15:85770561    C/A rs775843960 chr15:85770561    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MSL3	chrX:11787835(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MSL3	chrX:11779053-11779054(+) m6A 5'UTR//CDS//exon       27773535 chrX:11779092-11779093(+) m6A exon//intron       27773535 chrX:11779104-11779105(+) m6A exon//intron       27773535 chrX:11779133-11779134(+) m6A exon//intron       27773535 chrX:11779141-11779142(+) m6A exon//intron       27773535 chrX:11779648-11779649(+) m6A 5'UTR//CDS//exon//intron       24981863//22608085 chrX:11779692-11779693(+) m6A 5'UTR//CDS//exon//intron       24981863//22608085 chrX:11780256-11780257(+) m6A 3'UTR//5'UTR//CDS//exon       24981863//22608085 chrX:11780269-11780270(+) m6A 3'UTR//5'UTR//CDS//exon       24981863//22608085 chrX:11780293-11780294(+) m6A 3'UTR//CDS//exon       24981863//22608085 chrX:11780963-11780964(+) m6A 3'UTR//CDS//exon       24981863 chrX:11782268-11782269(+) m6A exon//intron       - chrX:11782283-11782284(+) m6A exon//intron       - chrX:11783597-11783598(+) m6A 3'UTR//CDS//intron       - chrX:11783669-11783670(+) m6A 3'UTR//CDS       - chrX:11787199-11787200(+) m6A exon//intron       - chrX:11787212-11787213(+) m6A exon//intron       - chrX:11790743-11790744(+) m6A 3'UTR//CDS       - chrX:11793178-11793179(+) m6A 3'UTR//CDS       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1276	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	MSL3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1276
Interactor2: MSL3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.