Basic Information:

  VIRBase ID:  

HHID00070766

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1276:  MIMAT0005930          SIVA1:  NM_021709     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1276	SIVA1
miRBase Accession/Entrez ID	MIMAT0005930	10572
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD27BP//SIVA//Siva-1//Siva-2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1276	rs372186220 chr15:85770551    C/T rs759704230 chr15:85770557    A/G rs949716743 chr15:85770550    T/C rs1469123493 chr15:85770565    T/C rs34381260 chr15:85770563    CT/C rs34381260 chr15:85770563    CT/CTT rs750237476 chr15:85770564    T/C rs764239400 chr15:85770562    T/C rs769744052 chr15:85770560    G/A rs775843960 chr15:85770561    C/A rs775843960 chr15:85770561    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SIVA1	chr14:105220137-105220138(+) m6A 5'UTR//intron       - chr14:105220183-105220184(+) m6A 5'UTR//intron       - chr14:105221971-105221972(+) m6A 5'UTR//CDS//exon//intron       - chr14:105222011-105222012(+) m6A 5'UTR//CDS//exon//intron       - chr14:105222114-105222115(+) m6A CDS//exon//intron       - chr14:105222385-105222386(+) m6A exon//intron       27773535 chr14:105222449-105222450(+) m6A exon//intron       27773535 chr14:105222608-105222609(+) m6A exon//intron       27773535 chr14:105222619-105222620(+) m6A exon//intron       27773535 chr14:105222893-105222894(+) m6A exon//intron       27773535 chr14:105222940-105222941(+) m6A CDS//exon       27773535 chr14:105223186-105223187(+) m6A 3'UTR//exon//intron       27773535 chr14:105223236-105223237(+) m6A 3'UTR//exon//intron       27773535 chr14:105223301-105223302(+) m6A 3'UTR//exon//intron       27773535 chr14:105223495-105223496(+) m6A 3'UTR//exon//intron       27773535 chr14:105225492-105225493(+) m6A exon//intron       27773535 chr14:105225613-105225614(+) m6A exon//intron       27773535 chr14:105225816-105225817(+) m6A CDS//exon//intron       - chr14:105225906-105225907(+) m6A 3'UTR//exon//intron       - chr14:105225974-105225975(+) m6A 3'UTR//exon//intron       - chr14:105233200-105233201(+) m6A 3'UTR       - chr14:105233208-105233209(+) m6A 3'UTR       - chr14:105233217-105233218(+) m6A 3'UTR       - chr14:105233225-105233226(+) m6A 3'UTR       - chr14:105234261-105234262(+) m6A 3'UTR       - chr14:105234298-105234299(+) m6A 3'UTR       - chr14:105234308-105234309(+) m6A 3'UTR       - chr14:105234321-105234322(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1276	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	SIVA1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1276
Interactor2: SIVA1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.