Basic Information:

  VIRBase ID:  

HHID00070760

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1276:  MIMAT0005930          PRC1:  NM_001267580     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1276	PRC1
miRBase Accession/Entrez ID	MIMAT0005930	9055
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ASE1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1276	rs372186220 chr15:85770551    C/T rs759704230 chr15:85770557    A/G rs949716743 chr15:85770550    T/C rs1469123493 chr15:85770565    T/C rs34381260 chr15:85770563    CT/C rs34381260 chr15:85770563    CT/CTT rs750237476 chr15:85770564    T/C rs764239400 chr15:85770562    T/C rs769744052 chr15:85770560    G/A rs775843960 chr15:85770561    C/A rs775843960 chr15:85770561    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRC1	chr15:91515909(-) A-I      intronic chr15:91514613(-) A-I      intronic chr15:91514640(-) A-I      intronic chr15:91521089(-) A-I      intronic chr15:91529770(-) A-I      intronic chr15:91529824(-) A-I      intronic chr15:91529830(-) A-I      intronic chr15:91533325(-) A-I      intronic chr15:91533381(-) A-I      intronic chr15:91534133(-) A-I      intronic chr15:91534173(-) A-I      intronic chr15:91534188(-) A-I      intronic chr15:91534296(-) A-I      intronic chr15:91534480(-) A-I      intronic chr15:91534524(-) A-I      intronic chr15:91534522(-) A-I      intronic chr15:91534546(-) A-I      intronic chr15:91534616(-) A-I      intronic chr15:91528926(-) A-I      intronic chr15:91520981(-) A-I      intronic chr15:91521017(-) A-I      intronic chr15:91521042(-) A-I      intronic chr15:91521058(-) A-I      intronic chr15:91528903(-) A-I      intronic chr15:91528965(-) A-I      intronic chr15:91529117(-) A-I      intronic chr15:91529185(-) A-I      intronic chr15:91529204(-) A-I      intronic chr15:91529710(-) A-I      intronic chr15:91529730(-) A-I      intronic chr15:91527632(-) A-I      intronic chr15:91527635(-) A-I      intronic chr15:91527548(-) A-I      intronic chr15:91529687(-) A-I      intronic chr15:91527677(-) A-I      intronic chr15:91527641(-) A-I      intronic chr15:91527583(-) A-I      intronic chr15:91534191(-) A-I      intronic chr15:91527672(-) A-I      intronic chr15:91527678(-) A-I      intronic chr15:91527636(-) A-I      intronic chr15:91527623(-) A-I      intronic chr15:91529752(-) A-I      intronic chr15:91527686(-) A-I      intronic chr15:91529213(-) A-I      intronic chr15:91515594(-) A-I      intronic chr15:91534502(-) A-I      intronic chr15:91521088(-) A-I      intronic chr15:91521097(-) A-I      intronic chr15:91534186(-) A-I      intronic chr15:91529769(-) A-I      intronic chr15:91534187(-) A-I      intronic chr15:91514974(-) A-I      intronic chr15:91534611(-) A-I      intronic chr15:91530435(-) A-I      intronic chr15:91529832(-) A-I      intronic chr15:91520178(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PRC1	chr15:91527548(-) A-I intron -    22028664 chr15:91527583(-) A-I intron -    22028664 chr15:91527623(-) A-I intron -    22028664 chr15:91527632(-) A-I intron -    22028664 chr15:91527635(-) A-I intron -    22028664 chr15:91527636(-) A-I intron -    22028664 chr15:91527641(-) A-I intron -    22028664 chr15:91527672(-) A-I intron -    22028664 chr15:91527677(-) A-I intron -    22028664 chr15:91527678(-) A-I intron -    22028664 chr15:91527686(-) A-I intron -    22028664

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRC1	chr15:91509557-91509558(-) m6A 3'UTR       27773535 chr15:91509722-91509723(-) m6A 3'UTR       27773535 chr15:91513739-91513740(-) m6A CDS//intron       27773535 chr15:91517248-91517249(-) m6A exon//intron       27773535 chr15:91517343-91517344(-) m6A exon//intron       24981863//27773535//27371828 chr15:91517360-91517361(-) m6A exon//intron       24981863//27773535//27371828 chr15:91517398-91517399(-) m6A CDS//exon       24981863//28052920//27773535//27371828 chr15:91517418-91517419(-) m6A CDS//exon       24981863//28052920//27773535//27371828 chr15:91517448-91517449(-) m6A CDS//exon       24981863//28052920//27773535//27371828 chr15:91517458-91517459(-) m6A CDS//exon       24981863//28052920//26404942//27773535//27371828 chr15:91517465-91517466(-) m6A CDS//exon       24981863//28052920//26404942//27773535//27371828 chr15:91517862-91517863(-) m6A CDS//exon       24981863//28052920//27773535//27371828 chr15:91517916-91517917(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr15:91517922-91517923(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr15:91519938-91519939(-) m6A CDS//exon       24981863//27773535//27371828 chr15:91519969-91519970(-) m6A CDS//exon       24981863//27773535//27371828 chr15:91522444-91522445(-) m6A CDS//exon       22575960 chr15:91522466-91522467(-) m6A CDS//exon       22575960 chr15:91524192-91524193(-) m6A CDS//exon       22575960 chr15:91524982-91524983(-) m6A CDS//exon       24981863//27371828//22608085 chr15:91525017-91525018(-) m6A CDS//exon       24981863//27371828//22608085 chr15:91525088-91525089(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085 chr15:91525118-91525119(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085 chr15:91525124-91525125(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085 chr15:91525142-91525143(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085 chr15:91527965-91527966(-) m6A CDS//exon//intron       22575960 chr15:91537672-91537673(-) m6A 5'UTR//exon       22575960 chr15:91537678-91537679(-) m6A 5'UTR//exon       22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1276	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	PRC1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1276
Interactor2: PRC1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.