Basic Information:

  VIRBase ID:  

HHID00070742

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1276:  MIMAT0005930          PNN:  NM_002687     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1276	PNN
miRBase Accession/Entrez ID	MIMAT0005930	5411
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DRS//DRSP//memA//SDK3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1276	rs372186220 chr15:85770551    C/T rs759704230 chr15:85770557    A/G rs949716743 chr15:85770550    T/C rs1469123493 chr15:85770565    T/C rs34381260 chr15:85770563    CT/C rs34381260 chr15:85770563    CT/CTT rs750237476 chr15:85770564    T/C rs764239400 chr15:85770562    T/C rs769744052 chr15:85770560    G/A rs775843960 chr15:85770561    C/A rs775843960 chr15:85770561    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PNN	chr14:39647692(+) A-I      intronic chr14:39647526(+) A-I      intronic chr14:39648022(+) A-I      intronic chr14:39648068(+) A-I      intronic chr14:39647677(+) A-I      intronic chr14:39647725(+) A-I      intronic chr14:39647669(+) A-I      intronic chr14:39647643(+) A-I      intronic chr14:39648042(+) A-I      intronic chr14:39647588(+) A-I      intronic chr14:39647648(+) A-I      intronic chr14:39647455(+) A-I      intronic chr14:39647684(+) A-I      intronic chr14:39647615(+) A-I      intronic chr14:39647657(+) A-I      intronic chr14:39648069(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PNN	chr14:39647643(+) A-I intron -    22327324 chr14:39647643(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PNN	chr14:39644501-39644502(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:39644512-39644513(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960 chr14:39644556-39644557(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960 chr14:39644625-39644626(+) Gm intron       - chr14:39645369-39645370(+) m6A exon//intron       24209618//24981863//22575960 chr14:39645386-39645387(+) m6A exon//intron       24209618//24981863//22575960 chr14:39645419-39645420(+) m6A exon//intron       24209618//24981863//22575960 chr14:39645424-39645425(+) m6A exon//intron       24209618//24981863//22575960 chr14:39645714-39645715(+) m6A exon//intron       24981863 chr14:39645757-39645758(+) m6A CDS//exon       24981863//27371828//22575960 chr14:39645769-39645770(+) m6A CDS//exon       24981863//27371828//27773536//22575960 chr14:39645777-39645778(+) m6A CDS//exon       24981863//27371828//27773536//22575960 chr14:39646634-39646635(+) m6A CDS       24981863//27773535//27371828//27773536//22575960 chr14:39646705-39646706(+) m6A CDS//intron       24981863//27773535 chr14:39646848-39646849(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr14:39647046-39647047(+) m6A CDS       24981863//27773535 chr14:39647092-39647093(+) m6A 3'UTR//CDS       24981863//27773535 chr14:39648221-39648222(+) m6A exon//intron       24981863//27773535 chr14:39648317-39648318(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960 chr14:39648323-39648324(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960 chr14:39648377-39648378(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960//22608085 chr14:39648401-39648402(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960//22608085 chr14:39648410-39648411(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960//22608085 chr14:39648425-39648426(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960//22608085 chr14:39648544-39648545(+) m6A CDS//exon       24981863//27773535//22575960//22608085 chr14:39648575-39648576(+) m6A CDS//exon       24981863//26404942//27773535//22608085 chr14:39648581-39648582(+) m6A CDS//exon       24981863//26404942//27773535//22608085 chr14:39648634-39648635(+) m6A CDS//exon       24981863//27773535//22608085 chr14:39649740-39649741(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr14:39649773-39649774(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:39649818-39649819(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:39649830-39649831(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:39649876-39649877(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:39649968-39649969(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:39649983-39649984(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:39649989-39649990(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:39650020-39650021(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr14:39650066-39650067(+) m1A CDS//intron       26863196 chr14:39650103-39650104(+) m6A CDS//intron       24209618//24981863//27773535//22575960//22608085 chr14:39650134-39650135(+) m6A CDS//intron       24209618//24981863//27773535//22575960//22608085 chr14:39650157-39650158(+) m6A CDS//intron       24981863//27773535//22575960 chr14:39650190-39650191(+) m6A CDS//intron       24981863//27773535//22575960 chr14:39650233-39650234(+) m6A CDS//intron       24981863//27773535 chr14:39650270-39650271(+) m6A CDS//intron       27773535 chr14:39650438-39650439(+) Y CDS//intron       25219674 chr14:39650520-39650521(+) m6A CDS//intron       27773535 chr14:39650561-39650562(+) Cm CDS//intron       - chr14:39650578-39650579(+) m6A CDS//intron       24209618//27773535//22575960 chr14:39650584-39650585(+) m6A CDS//intron       24209618//27773535//22575960 chr14:39650620-39650621(+) m6A CDS//intron       24209618//27773535//22575960 chr14:39650829-39650830(+) m6A CDS//intron       24209618//24981863//27773535//22608085 chr14:39650837-39650838(+) Gm CDS//intron       - chr14:39650861-39650862(+) Tm CDS//intron       - chr14:39650889-39650890(+) m6A CDS//intron       24209618//24981863//27773535//22575960//22608085 chr14:39651032-39651033(+) m6A CDS//intron       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chr14:39651044-39651045(+) m6A CDS//intron       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chr14:39651053-39651054(+) m6A CDS//intron       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chr14:39651199-39651200(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr14:39651215-39651216(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr14:39651929-39651930(+) m6A 3'UTR//exon       27773535 chr14:39652085-39652086(+) m6A 3'UTR       27773535 chr14:39652138-39652139(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1276	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	PNN	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1276
Interactor2: PNN

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.