Basic Information:

  VIRBase ID:  

HHID00070727

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          CRTC2:  NM_181715     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	CRTC2
miRBase Accession/Entrez ID	MIMAT0005929	200186
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TORC-2//TORC2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CRTC2	chr1:153922573(-) A-I      intronic chr1:153922324(-) A-I      intronic chr1:153922684(-) A-I      intronic chr1:153922662(-) A-I      intronic chr1:153922661(-) A-I      intronic chr1:153922216(-) A-I      intronic chr1:153922225(-) A-I      intronic chr1:153922517(-) A-I      intronic chr1:153922569(-) A-I      intronic chr1:153922547(-) A-I      intronic chr1:153922238(-) A-I      intronic chr1:153922157(-) A-I      intronic chr1:153922625(-) A-I      intronic chr1:153922530(-) A-I      intronic chr1:153922263(-) A-I      intronic chr1:153922067(-) A-I      intronic chr1:153922487(-) A-I      intronic chr1:153922243(-) A-I      intronic chr1:153922670(-) A-I      intronic chr1:153922145(-) A-I      intronic chr1:153922079(-) A-I      intronic chr1:153922159(-) A-I      intronic chr1:153922603(-) A-I      intronic chr1:153922581(-) A-I      intronic chr1:153922120(-) A-I      intronic chr1:153922511(-) A-I      intronic chr1:153922242(-) A-I      intronic chr1:153922626(-) A-I      intronic chr1:153922444(-) A-I      intronic chr1:153922203(-) A-I      intronic chr1:153922464(-) A-I      intronic chr1:153922080(-) A-I      intronic chr1:153922133(-) A-I      intronic chr1:153922627(-) A-I      intronic chr1:153922239(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CRTC2	chr1:153922079(-) A-G intron -    22484847 chr1:153922145(-) A-G intron -    22484847 chr1:153922157(-) A-G intron -    22484847 chr1:153922159(-) A-G intron -    22484847 chr1:153922225(-) A-G intron -    22484847 chr1:153922238(-) A-G intron -    22484847 chr1:153922239(-) A-G intron -    22484847 chr1:153922242(-) A-G intron -    22484847 chr1:153922243(-) A-G intron -    22484847 chr1:153922263(-) A-G intron -    22484847 chr1:153922511(-) A-G intron -    22484847 chr1:153922627(-) A-G intron -    22484847 chr1:153925631(-) G-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CRTC2	chr1:153920150-153920151(-) m6A 3'UTR       27773535 chr1:153920349-153920350(-) m6A 3'UTR//exon       24284625//25456834//28052920//27773535//27371828 chr1:153920384-153920385(-) m6A 3'UTR//exon       24284625//25456834//28052920//27773535//27371828//22575960 chr1:153920504-153920505(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//27371828//22608085 chr1:153920660-153920661(-) m6A 3'UTR//CDS//exon       24284625//27773535//27371828 chr1:153920983-153920984(-) m6A 3'UTR//CDS//exon       27773535 chr1:153921667-153921668(-) m6A 3'UTR//CDS//exon       27773535 chr1:153921836-153921837(-) m6A 3'UTR//CDS//exon       24284625//27773535 chr1:153923780-153923781(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535 chr1:153924140-153924141(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//27371828 chr1:153924604-153924605(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//28052920//27773535//27371828 chr1:153924615-153924616(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//28052920//27773535//27371828 chr1:153924681-153924682(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535 chr1:153925806-153925807(-) m6A 3'UTR//CDS//exon//intron       27773535 chr1:153927627-153927628(-) m6A CDS//exon//intron       - chr1:153930631-153930632(-) m6A exon//intron       - chr1:153930637-153930638(-) m6A exon//intron       - chr1:153930656-153930657(-) m1A exon//intron       26863196 chr1:153930836-153930837(-) m6A CDS//exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	CRTC2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: CRTC2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.