Basic Information:

  VIRBase ID:  

HHID00070721

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          NSUN3:  NM_022072     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	NSUN3
miRBase Accession/Entrez ID	MIMAT0005929	63899
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	COXPD48//MST077//MSTP077

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NSUN3	chr3:93808791(+) A-I      intronic chr3:93809882(+) A-I      intronic chr3:93809905(+) A-I      intronic chr3:93809906(+) A-I      intronic chr3:93805022(+) A-I      intronic chr3:93809908(+) A-I      intronic chr3:93809914(+) A-I      intronic chr3:93809907(+) A-I      intronic chr3:93807635(+) A-I      intronic chr3:93807620(+) A-I      intronic chr3:93806658(+) A-I      intronic chr3:93811552(+) A-I      intronic chr3:93814685(+) A-I      intronic chr3:93804927(+) A-I      intronic chr3:93804523(+) A-I      intronic chr3:93804512(+) A-I      intronic chr3:93808744(+) A-I      intronic chr3:93826288(+) A-I      intronic chr3:93815479(+) A-I      intronic chr3:93814665(+) A-I      intronic chr3:93814655(+) A-I      intronic chr3:93811670(+) A-I      intronic chr3:93806751(+) A-I      intronic chr3:93804985(+) A-I      intronic chr3:93808761(+) A-I      intronic chr3:93808769(+) A-I      intronic chr3:93808728(+) A-I      intronic chr3:93808735(+) A-I      intronic chr3:93808736(+) A-I      intronic chr3:93808739(+) A-I      intronic chr3:93808759(+) A-I      intronic chr3:93804509(+) A-I      intronic chr3:93806679(+) A-I      intronic chr3:93808780(+) A-I      intronic chr3:93807617(+) A-I      intronic chr3:93806722(+) A-I      intronic chr3:93846953(+) A-I      3'UTR chr3:93846901(+) A-I      3'UTR chr3:93846993(+) A-I      3'UTR chr3:93847000(+) A-I      3'UTR chr3:93847020(+) A-I      3'UTR chr3:93846815(+) A-I      3'UTR chr3:93846905(+) A-I      3'UTR chr3:93846916(+) A-I      3'UTR chr3:93846908(+) A-I      3'UTR chr3:93846904(+) A-I      3'UTR chr3:93846889(+) A-I      3'UTR chr3:93846818(+) A-I      3'UTR chr3:93846907(+) A-I      3'UTR chr3:93846913(+) A-I      3'UTR chr3:93846914(+) A-I      3'UTR chr3:93846944(+) A-I      3'UTR chr3:93804417(+) A-I      intronic chr3:93811523(+) A-I      intronic chr3:93806538(+) A-I      intronic chr3:93807616(+) A-I      intronic chr3:93811528(+) A-I      intronic chr3:93811617(+) A-I      intronic chr3:93811605(+) A-I      intronic chr3:93811562(+) A-I      intronic chr3:93807596(+) A-I      intronic chr3:93804391(+) A-I      intronic chr3:93807787(+) A-I      intronic chr3:93804441(+) A-I      intronic chr3:93806539(+) A-I      intronic chr3:93811644(+) A-I      intronic chr3:93811492(+) A-I      intronic chr3:93811519(+) A-I      intronic chr3:93821835(+) A-I      intronic chr3:93804482(+) A-I      intronic chr3:93846859(+) A-I      3'UTR chr3:93846961(+) A-I      3'UTR chr3:93846948(+) A-I      3'UTR chr3:93846890(+) A-I      3'UTR chr3:93846888(+) A-I      3'UTR chr3:93846906(+) A-I      3'UTR chr3:93846921(+) A-I      3'UTR chr3:93846810(+) A-I      3'UTR chr3:93846856(+) A-I      3'UTR chr3:93846941(+) A-I      3'UTR chr3:93846809(+) A-I      3'UTR chr3:93804542(+) A-I      intronic chr3:93806534(+) A-I      intronic chr3:93811604(+) A-I      intronic chr3:93806696(+) A-I      intronic chr3:93789313(+) A-I      intronic chr3:93804504(+) A-I      intronic chr3:93811564(+) A-I      intronic chr3:93811705(+) A-I      intronic chr3:93806615(+) A-I      intronic chr3:93806775(+) A-I      intronic chr3:93811608(+) A-I      intronic chr3:93804971(+) A-I      intronic chr3:93811611(+) A-I      intronic chr3:93811572(+) A-I      intronic chr3:93804442(+) A-I      intronic chr3:93807581(+) A-I      intronic chr3:93806644(+) A-I      intronic chr3:93811709(+) A-I      intronic chr3:93811493(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NSUN3	chr3:93794677(+) A-I intron -    22327324 chr3:93806615(+) A-I intron -    22327324 chr3:93808753(+) A-I intron -    22327324 chr3:93808788(+) A-I intron -    22327324 chr3:93809932(+) A-I intron -    22327324 chr3:93809870(+) A-G intron -    22484847 chr3:93809876(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NSUN3	chr3:93781892-93781893(+) m6A 5'UTR//exon       24981863 chr3:93781967-93781968(+) m6A 5'UTR//exon       24981863 chr3:93783312-93783313(+) m6A CDS//exon       24981863 chr3:93783348-93783349(+) m6A CDS//exon       24981863 chr3:93783363-93783364(+) m6A CDS//exon       24981863 chr3:93795295-93795296(+) m6A exon//intron       22608085 chr3:93795301-93795302(+) m6A exon//intron       22608085 chr3:93803019-93803020(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr3:93803113-93803114(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr3:93803139-93803140(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr3:93803153-93803154(+) m6A CDS//exon//intron       22608085 chr3:93813947-93813948(+) Y CDS       26075521 chr3:93845152-93845153(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr3:93845179-93845180(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:93845199-93845200(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:93845347-93845348(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	NSUN3	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: NSUN3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.