Basic Information:

  VIRBase ID:  

HHID00070714

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          AFTPH:  NR_164746     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	AFTPH
miRBase Accession/Entrez ID	MIMAT0005929	54812
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Nbla10388

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AFTPH	chr2:64775074(+) A-I      intronic chr2:64787845(+) A-I      intronic chr2:64791681(+) A-I      intronic chr2:64775066(+) A-I      intronic chr2:64792073(+) A-I      intronic chr2:64787846(+) A-I      intronic chr2:64791657(+) A-I      intronic chr2:64775103(+) A-I      intronic chr2:64782574(+) A-I      intronic chr2:64773152(+) A-I      intronic chr2:64763840(+) A-I      intronic chr2:64774095(+) A-I      intronic chr2:64792153(+) A-I      intronic chr2:64791628(+) A-I      intronic chr2:64791627(+) A-I      intronic chr2:64787935(+) A-I      intronic chr2:64787903(+) A-I      intronic chr2:64774956(+) A-I      intronic chr2:64775085(+) A-I      intronic chr2:64775343(+) A-I      intronic chr2:64775361(+) A-I      intronic chr2:64757235(+) A-I      intronic chr2:64757255(+) A-I      intronic chr2:64758103(+) A-I      intronic chr2:64802573(+) A-I      intronic chr2:64763853(+) A-I      intronic chr2:64763854(+) A-I      intronic chr2:64763858(+) A-I      intronic chr2:64763859(+) A-I      intronic chr2:64775367(+) A-I      intronic chr2:64802644(+) A-I      intronic chr2:64775406(+) A-I      intronic chr2:64775433(+) A-I      intronic chr2:64787031(+) A-I      intronic chr2:64792446(+) A-I      intronic chr2:64792443(+) A-I      intronic chr2:64792234(+) A-I      intronic chr2:64802661(+) A-I      intronic chr2:64802679(+) A-I      intronic chr2:64773066(+) A-I      intronic chr2:64773168(+) A-I      intronic chr2:64802739(+) A-I      intronic chr2:64773227(+) A-I      intronic chr2:64773895(+) A-I      intronic chr2:64773985(+) A-I      intronic chr2:64774062(+) A-I      intronic chr2:64787856(+) A-I      intronic chr2:64787864(+) A-I      intronic chr2:64787868(+) A-I      intronic chr2:64800945(+) A-I      intronic chr2:64800953(+) A-I      intronic chr2:64802740(+) A-I      intronic chr2:64803002(+) A-I      intronic chr2:64803025(+) A-I      intronic chr2:64803120(+) A-I      intronic chr2:64803993(+) A-I      intronic chr2:64804005(+) A-I      intronic chr2:64804022(+) A-I      intronic chr2:64801001(+) A-I      intronic chr2:64794984(+) A-I      intronic chr2:64792541(+) A-I      intronic chr2:64792537(+) A-I      intronic chr2:64792521(+) A-I      intronic chr2:64792448(+) A-I      intronic chr2:64801036(+) A-I      intronic chr2:64802526(+) A-I      intronic chr2:64802531(+) A-I      intronic chr2:64802620(+) A-I      intronic chr2:64795013(+) A-I      intronic chr2:64795089(+) A-I      intronic chr2:64800842(+) A-I      intronic chr2:64800853(+) A-I      intronic chr2:64800869(+) A-I      intronic chr2:64800891(+) A-I      intronic chr2:64800931(+) A-I      intronic chr2:64802666(+) A-I      intronic chr2:64763566(+) A-I      intronic chr2:64802604(+) A-I      intronic chr2:64774948(+) A-I      intronic chr2:64795861(+) A-I      intronic chr2:64756890(+) A-I      intronic chr2:64773101(+) A-I      intronic chr2:64773905(+) A-I      intronic chr2:64758031(+) A-I      intronic chr2:64802545(+) A-I      intronic chr2:64803082(+) A-I      intronic chr2:64775199(+) A-I      intronic chr2:64763717(+) A-I      intronic chr2:64802973(+) A-I      intronic chr2:64774938(+) A-I      intronic chr2:64756939(+) A-I      intronic chr2:64792426(+) A-I      intronic chr2:64795108(+) A-I      intronic chr2:64774936(+) A-I      intronic chr2:64803022(+) A-I      intronic chr2:64775020(+) A-I      intronic chr2:64757211(+) A-I      intronic chr2:64792025(+) A-I      intronic chr2:64756863(+) A-I      intronic chr2:64757134(+) A-I      intronic chr2:64790879(+) A-I      intronic chr2:64763423(+) A-I      intronic chr2:64760406(+) A-I      intronic chr2:64775087(+) A-I      intronic chr2:64802977(+) A-I      intronic chr2:64763624(+) A-I      intronic chr2:64773126(+) A-I      intronic chr2:64756814(+) A-I      intronic chr2:64757143(+) A-I      intronic chr2:64775109(+) A-I      intronic chr2:64774052(+) A-I      intronic chr2:64803020(+) A-I      intronic chr2:64787886(+) A-I      intronic chr2:64756817(+) A-I      intronic chr2:64775060(+) A-I      intronic chr2:64775084(+) A-I      intronic chr2:64792083(+) A-I      intronic chr2:64756954(+) A-I      intronic chr2:64757169(+) A-I      intronic chr2:64773166(+) A-I      intronic chr2:64803125(+) A-I      intronic chr2:64774940(+) A-I      intronic chr2:64773289(+) A-I      intronic chr2:64795844(+) A-I      intronic chr2:64757170(+) A-I      intronic chr2:64773131(+) A-I      intronic chr2:64776581(+) A-I      intronic chr2:64802972(+) A-I      intronic chr2:64774989(+) A-I      intronic chr2:64800989(+) A-I      intronic chr2:64775272(+) A-I      intronic chr2:64795929(+) A-I      intronic chr2:64791625(+) A-I      intronic chr2:64795843(+) A-I      intronic chr2:64756787(+) A-I      intronic chr2:64775177(+) A-I      intronic chr2:64792090(+) A-I      intronic chr2:64756848(+) A-I      intronic chr2:64775019(+) A-I      intronic chr2:64787887(+) A-I      intronic chr2:64756867(+) A-I      intronic chr2:64775045(+) A-I      intronic chr2:64754453(+) A-I      intronic chr2:64775058(+) A-I      intronic chr2:64782670(+) A-I      intronic chr2:64800892(+) A-I      intronic chr2:64757240(+) A-I      intronic chr2:64792091(+) A-I      intronic chr2:64775187(+) A-I      intronic chr2:64792102(+) A-I      intronic chr2:64760539(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	AFTPH	chr2:64756787(+) A-G intron -    22484847 chr2:64756817(+) A-G intron -    22484847 chr2:64756863(+) A-G intron -    22484847 chr2:64756903(+) A-G intron -    22484847 chr2:64757169(+) A-G intron -    22484847 chr2:64757170(+) A-G intron -    22484847 chr2:64757211(+) A-G intron -    22484847 chr2:64760406(+) A-G intron -    22484847 chr2:64763944(+) G-A intron -    22484847 chr2:64773166(+) A-G intron -    22484847 chr2:64774936(+) A-G intron -    22484847 chr2:64774938(+) A-G intron -    22484847 chr2:64774940(+) A-G intron -    22484847 chr2:64774989(+) A-G intron -    22484847 chr2:64775019(+) A-G intron -    22484847 chr2:64775020(+) A-G intron -    22484847 chr2:64775084(+) A-G intron -    22484847 chr2:64775087(+) A-G intron -    22484847 chr2:64775104(+) A-G intron -    22484847 chr2:64775109(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AFTPH	chr2:64751583-64751584(+) m6A 5'UTR       28052920//27371828 chr2:64778605-64778606(+) m6A 5'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64778618-64778619(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64778657-64778658(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64778795-64778796(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr2:64778879-64778880(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr2:64778892-64778893(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr2:64778913-64778914(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr2:64778997-64778998(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64779030-64779031(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr2:64779043-64779044(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr2:64779076-64779077(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr2:64779101-64779102(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr2:64779178-64779179(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr2:64779196-64779197(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr2:64779209-64779210(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr2:64779272-64779273(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr2:64779398-64779399(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr2:64779423-64779424(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr2:64779476-64779477(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64779549-64779550(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64779623-64779624(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr2:64779657-64779658(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr2:64779667-64779668(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr2:64779678-64779679(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr2:64779730-64779731(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr2:64779797-64779798(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64780026-64780027(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:64780084-64780085(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr2:64780103-64780104(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr2:64780110-64780111(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr2:64780165-64780166(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:64780176-64780177(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:64780188-64780189(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:64780218-64780219(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr2:64780268-64780269(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr2:64780286-64780287(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:64780341-64780342(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64780376-64780377(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64780429-64780430(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64780456-64780457(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64794708-64794709(+) m6A CDS//exon//intron       24284625//24981863//26404942//22608085 chr2:64819183-64819184(+) m6A 3'UTR//exon       24284625//24981863//26404942//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	AFTPH	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: AFTPH

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.